Isoxepac
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- CAS-Nr.
- 55453-87-7
- Englisch Name:
- Isoxepac
- Synonyma:
- 2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid;Olapatadine;Olopatadine Related CoMpound C;6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID;6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid;artil;hp549;ND4-B2;isoxepac;P-720549
- CBNumber:
- CB3466254
- Summenformel:
- C16H12O4
- Molgewicht:
- 268.26
- MOL-Datei:
- 55453-87-7.mol
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Isoxepac Eigenschaften
- Schmelzpunkt:
- 130-132°C
- Siedepunkt:
- 528.2±50.0 °C(Predicted)
- Dichte
- 1.39 g/cm3
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- soluble in Methanol
- Aggregatzustand
- Solid
- pka
- 4.24±0.10(Predicted)
- Farbe
- White to Light yellow to Light orange
- Merck
- 14,5237
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1S/C16H12O4/c17-15(18)8-10-5-6-14-13(7-10)16(19)12-4-2-1-3-11(12)9-20-14/h1-7H,8-9H2,(H,17,18)
- InChIKey
- QFGMXJOBTNZHEL-UHFFFAOYSA-N
- SMILES
- O1CC2=CC=CC=C2C(=O)C2=CC(CC(O)=O)=CC=C12
- CAS Datenbank
- 55453-87-7(CAS DataBase Reference)
Isoxepac Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Beige Solid
Verwenden
Isoxepac is a non-steroidal anti-inflammatory with analgesic and antipyretic activity. It is more slowly absorbed and eliminated in the rat and rabbit after oral dosing than in the dog, rhesus monkey and man.It can be used to treat allergic rhinitis, urticaria, and skin diseases with itching symptoms.
synthetische
Isoxic acid is an important intermediate in the synthesis of the new preferred anti-allergic drug, olopatadine hydrochloride, preparation method of isoxepac:
(1) condensation: prepare p-hydroxyphenylaceticacid 8-12 part, phthalide 6-12 part, sodium methylate 8-12 part by weight; Dissolve with DMAC and to add said sodium methylate behind said p-hydroxyphenylaceticacid and the phthalide; Be that 0.1-10Pa is heated to 80-170 ℃ of reaction 3-10h at pressure then; Regulate the pH value to 1-5,4-(2-carboxyl benzyloxy) toluylic acid is separated out in crystallization;
(2) cyclization: with Glacial acetic acid min. 99.5 dissolving step (1) gained 4-(2-carboxyl benzyloxy) toluylic acid, adding 3-52 weight part polyphosphoric acid again, is that 0.1-10Pa is heated to 30-100 ℃ of reaction 3-12h at pressure, and crystallisation by cooling gets the Isoxepac bullion then;
(3) purify: behind the said Isoxepac bullion of acetic acid ethyl dissolution, refining decolouring gets the Isoxepac product.
https://patents.google.com/patent/CN102838582A/en
Definition
ChEBI: Isoxepac is a dibenzooxazepine.
Trademarks
Artil(Hoechst-Roussel)
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Isoxepac Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Isoxepac Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 388)Lieferanten
55453-87-7()Verwandte Suche:
- 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic acid (Olopatadine)
- Olopatadine Related Compound C (35 mg) ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid)
- ND4-B2
- artil
- isoxepac
- (11-OXO-6,11-DIHYDRODIBENZO[B,E]OXEPIN-2-YL)ACETIC ACID
- 11-Oxo-6,11-dihydrodibenz[b,e]oxepin-2-acetic Acid
- NSC 300907
- Isoxepac-d6
- Olopatadine Related CoMpund C
- Olopatadine USP RC C
- e)oxepin-2-aceticacid,6,11-dihydro-11-oxo-dibenz(
- hp549
- DIBENZ[B,E]OXEPIN-2-ACETIC ACID, 6,11-DIOHYDRO-11-OXO
- 6,11-Hydro-11-Oxo-Dibenz[B,E]Oxepin-2-Acetic Acid
- 11-Oxo-6,11-Dihydrobenz(b,e)oxepin-2-Acetic Acid (Isoxepac)
- Isoxepac (Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-oxo)
- 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic
- 6,11-Dihydro-11-oxodibenz[b,e]oxepine-2-acetic acid
- P-720549
- 6,11-dihydro-11-oxodibenz[b,e]opepin-2-acetic acid
- 2-(11-keto-6H-benzo[c][2]benzoxepin-2-yl)acetic acid
- 2-(11-oxo-6H-benzo[c][2]benzoxepin-2-yl)acetic acid
- 2-(11-oxo-6H-benzo[c][2]benzoxepin-2-yl)ethanoic acid
- 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid (Isoxepac)
- 6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID(FOR OLOPATADINE)
- Olotatadine related compound C
- Olopatadine USP Related Compound C
- e]oxepin-2-acetic acid
- 11-Dihydro-11-oxo-dibenz[b
- 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-aceticAcid>
- Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-oxo-
- Olopatadine Related Compound C (35 mg)
- 6H-11-Oxodibenzo[b,e]oxepin-2-acetic Acid
- TIANFU-CHEM 55453-87-7 Isoxepac
- Olopatadine Related Compound C ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid) (1478436)
- 16-trihydroxy-palmitic acid
- Olopatadine Impurity 3（Olopatadine USP RC C）
- 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic acid, 97.0%
- Isoxepac-HBW
- 6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID
- 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid
- Olotadine Hydrochloride Isoclate
- (11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic Acid (Isoxepac)
- Isoxic acid
- 2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)aceticaci
- OLOPATADINE EP IMP C
- 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid or Isopec
- Olopatadine USP Related Compound C (Isoxepac)
- Isoxepac, 10 mM in DMSO
- OLOPATADINE EP IMPURITY C
- 2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid
- Olopatadine Related CoMpound C
- Olapatadine
- 55453-87-7
- 1313-91-1
- 55453-67-7
- 54453-87-7
