PD 166793

199850-67-4

CAS-Nr.: 199850-67-4

Englisch Name:: PD 166793

Synonyma:: PD 166793;PD-166793-0000;PD 166793 USP/EP/BP;MMP-2/MMP-3 Inhibitor;PD-166793, 10 mM in DMSO;MMP-2/MMP-3 Inhibitor III, PD166793;N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine;L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-;(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid;(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci

CBNumber:: CB3840520

Summenformel:: C17H18BrNO4S

Molgewicht:: 412.3

MOL-Datei:: 199850-67-4.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 76

PD 166793 Eigenschaften

Schmelzpunkt:: 192-193℃

Dichte: 1.457

storage temp.: Sealed in dry,2-8°C

L?slichkeit: DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml

Aggregatzustand: A crystalline solid

Farbe: White to pink

InChI: 1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1

InChIKey: GJOCABIDMCKCEG-INIZCTEOSA-N

SMILES: [S](=O)(=O)(N[C@@H](C(C)C)C(=O)O)c1ccc(cc1)c2ccc(cc2)Br

Sicherheit

WGK Germany	WGK 2
Speicherklasse	11 - Combustible Solids

PD 166793 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.

Allgemeine Beschreibung

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC₅₀ = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC₅₀ = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

Biologische Aktivit?t

Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

PD 166793 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PD 166793 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 76)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30224	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28760	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49954	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15838	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64

199850-67-4()Verwandte Suche:

Decabrom-1,1'-biphenyl 2,2-Diphenyl-1-picrylhydrazyl

PD 166793
(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid
N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
MMP-2/MMP-3 Inhibitor
L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-
(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci
PD 166793 USP/EP/BP
PD-166793-0000
PD-166793, 10 mM in DMSO
MMP-2/MMP-3 Inhibitor III, PD166793
199850-67-4
Angiogenesis and Metastasis
Protease inhibitor

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