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Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Struktur
144689-93-0
CAS-Nr.
144689-93-0
Englisch Name:
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate
Synonyma:
4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-carboxylate;ETHYL-4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATE;Olmesartan intermediate;4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid;5-(1-HYDROXYL-1-METHYLETHYL)-2-PROPYL-IMIDAZOL-4-YLCARBOXYLIC ACID ETHYL ESTER;1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester;OMSTint-D;)-2-propyL;Olmesartan Impurity 2
CBNumber:
CB4151009
Summenformel:
C12H20N2O3
Molgewicht:
240.3
MOL-Datei:
144689-93-0.mol

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Eigenschaften

Schmelzpunkt:
98-100°C
Siedepunkt:
456.2±35.0 °C(Predicted)
Dichte
1.131±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
L?slichkeit
Chloroform, Ethyl Acetate, Methanol
Aggregatzustand
Solid
pka
11.61±0.10(Predicted)
Farbe
Pale Yellow
InChI
InChI=1S/C12H20N2O3/c1-5-7-8-13-9(11(15)17-6-2)10(14-8)12(3,4)16/h16H,5-7H2,1-4H3,(H,13,14)
InChIKey
KZBJJAFGNMRRHN-UHFFFAOYSA-N
SMILES
C1(CCC)NC(C(OCC)=O)=C(C(O)(C)C)N=1
CAS Datenbank
144689-93-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2933.29.9000
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Pale Yellow Solid

Application

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a synthetic drug with pharmacological properties that are similar to those of the natural product medoxomil. It has been shown to be a potent blocker of the GABA receptor and is used for the treatment of epilepsy.It has been shown to be an inhibitor of rat liver microsomes and also has a high affinity for the enzyme cilexetil, which is responsible for the conversion of cilexetil into its active form.

Definition

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a crucial intermediate for the synthesis of olmesartan medoxomil, which can be produced via the reaction of diethyl 2-propyl-imidazole-4,5-dicarboxylate, the raw material, with methylmagnesium bromide, followed by the acidification with saturated ammonium chloride solution.

Hazard

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is sensitive to the skin and may cause allergic skin reactions. It is irritating to the skin and eyes and may also cause respiratory irritation. It is poisonous to aquatic organisms.

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Methylmagnesiumchlorid Chlormethan Brommethan 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid Ethanol Olmesartan Impurity 9 Diethyl 2-propylImidazoledicarbonate Ammoniumchlorid Dichlormethan Tetrahydrofuran

Downstream Produkte

Olmesartan Medoxomil Trityl olmesartan Trityl Olmesartan Medoxomil 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 529)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
 trendseenbio@gmail.com China 11681 58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD
+86-576-88902229;+86-0576-88902229 +8613968687450
 yuxin@yuxchem.com China 167 58
Jinan Dexinjia Bio&Tech Co., Ltd
+86-0531-82375818 +86-15064153060
 sales@jndxj.com China 1286 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410
 sales@ichemie.com China 1006 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858
 daisy@anhuiruihan.com China 973 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 20122 58
airuikechemical co., ltd. 		+86-18353166132
sales02@airuikechemical.com China 983 58
Sinoway Industrial co., ltd. 		+86-0592-5800732 +86-13806035118
 xie@china-sinoway.com China 1369 58
Capot Chemical Co.,Ltd. 		+8613336195806
 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036
info@dakenam.com China 13901 58

144689-93-0()Verwandte Suche:

  • 1H-Imidazole-4-carboxylicacid,5-(1-hydroxy-1-met
  • 1H-Imidazole-5-carboxylicacid,4-(1-hydroxy-1-met
  • 1H-Imidazole-4-carboxylic acid,5-(1-hydroxy-1-methylethyl)-2- propyl-,ethyl ester
  • 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 98+%
  • 5-(1-hydroxy-1-methylethyl)-2-propyl-,ethyl ester
  • 4-(1-Hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid ethyl ester
  • 4-(1-Hydroxy-1-methylethyl)-2-propyl-
  • 5-(1-hydroxy-1-Methylethyl)-2-propyl-1H-IMidazole- 4-carboxylic acid ethyl ester
  • 1H-Imidazole-4-carboxylic acid, 5-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester (9CI)
  • 5-(1-Hydroxy-1-Methyl-ethyl)-2-propyl-3H-iMidazole-4-carboxylic acid ethyl ester
  • Ethyl 4-(2-Hydroxy-2-propyl)-2-propyl-1H-iMidazole-5-carboxylate
  • OlMesartan IMidazole Ethyl Ester IMpurity
  • 1h-iMdazole-4-carboxylic acid, 5-(1-hydroxy-1-Methylethyl)-2-propyl-,ethyl ester
  • 1H-IMIDAZOLE-4-CARBOXYLIC ACID-5-(1-HYDROXY-1-METHYETHYL)-2-PROPYL-ETHYL ESTER
  • OlMesartan IMpurity (Ethyl 4-(1-Hydroxy-1-Methylethyl)-2- Propyl-IMidazole-5-Carboxylate)
  • 4-(2-Hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-carboxylic acid ethyl ester (EPIC)
  • Ethyl 4-(1-hydroxy-1-Methylethyl)-2-propyliM...
  • Ethyl 4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylate
  • 4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester (OM-7)
  • 4-(1-Hydroxy-isopropyl)-2-propyl-1H-imidazol-5-carboxylic acid ethyl ester
  • Olmesartan Medoxomil Impurity 33
  • Olmesartan Medoxomil-18
  • OMSTint-D
  • ethyl 5-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-4-carboxylate
  • Olmesartan Impurity 2
  • Olmesartan Impurity 50
  • 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate
  • Ethyl4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylate>
  • 4-(1-hydroxy-1-methyL
  • 4-(1-Hydroxy-1-methylethyl)-2-Propyl-1H-Imiidazole 5-Carboxylic acid ethyl ester
  • )-2-propyL
  • 4-(2-hydroxy-2-propyl) -2-propyl-1H-imidazole-5-formate, ethyl ester
  • 4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylic Acid Ethyl Ester
  • Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate USP/EP/BP
  • 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester for olmesartan
  • 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYL IC ACID ETHYL ESTEROLE
  • Imidazole-5-carboxylic ethyl ester
  • [5-(1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4-yl]carboxy...
  • Azilsartan medoxomil impurity230
  • ETHYL-4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATE
  • Olmesartan intermediate
  • 5-(1-HYDROXYL-1-METHYLETHYL)-2-PROPYL-IMIDAZOL-4-YLCARBOXYLIC ACID ETHYL ESTER
  • 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester
  • 4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid
  • 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxyhio acid ethyl ester
  • (1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4- yl]carboxylic acid ethyl ester
  • Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carbo
  • Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazol-5-carboxylate
  • Ethyl 5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylate
  • Olmesartan ester impurity 27
  • Ethy-4-(1-Hydroxy-1-Mmethylethyl)-2-propylImidazole-5-Carboxylate.
  • Ethyl5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4- carboxylate (Imidazole Ester)
  • OLM intermediate (4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester)
  • 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-Imidazole
  • 4-<( 1-Hydroxy-1-Methylethyl)-2 Propyl-1H-lmidazole- 5-Carboxylic Acid Ethyl Ester
  • Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate (Olmesartan Impurity)
  • Olmesartan Imidazole Ethyl Ester Impurity Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5- carboxylate
  • 4-(1-Hydroxy-1-methylpropyl)-2-propyl-1H-imidazole-5-carboxylate
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