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Pemetrexed Disodium

Pemetrexed Disodium Struktur
150399-23-8
CAS-Nr.
150399-23-8
Englisch Name:
Pemetrexed Disodium
Synonyma:
ALIMTA;LY-231514;PEMETREXED SODIUM;PeMetexed DisodiuM;Alimt;AliMta disodiuM;LY231514 disodiuM;LY 231514 disodiuM;LY-231514 disodiuM;Pemwtrexed Disodium
CBNumber:
CB4385473
Summenformel:
C20H22N5NaO6
Molgewicht:
451.41
MOL-Datei:
150399-23-8.mol

Pemetrexed Disodium Eigenschaften

Schmelzpunkt:
254-258°C (dec.)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
L?slichkeit
Methanol, Water
Aggregatzustand
Solid
Farbe
Off-White
Stabilit?t:
Hygroscopic
InChIKey
UTEALKYVANXUSG-NVZXTOETNA-N
SMILES
C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH] |&1:20,r|
CAS Datenbank
150399-23-8(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T;Xi,Xi,T
R-S?tze: 36/38-60-61-68
S-S?tze: 36/37/39-53
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Pemetrexed Disodium Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/38:Reizt die Augen und die Haut.
R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.
R61:Kann das Kind im Mutterleib sch?digen.
R68:Irreversibler Schaden m?glich.

S-S?tze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.

Chemische Eigenschaften

Crystalline Solid

Definition

ChEBI: An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 4 1 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).

Allgemeine Beschreibung

The drug is available in a 100-mg sterile vial for IV use. Thedrug appears to be effective against a range of tumors includingmesothelioma, NSCLC, colorectal cancer, bladdercancer, and lung cancer. The mechanism of action involvesinhibition of TS resulting in inhibition of thymidylate andDNA synthesis. This drug is a pyrrolopyrimidine analog offolate with antifolate activity. Resistance can occur by increasedexpression of TS, decreased binding affinity for TS,or decreased drug transport into cells. The drug is administeredonly via the IV route and distributes to all tissues.Cellular activation to the more potent polyglutamated formsoccurs, and the majority of the dose is excreted unchangedin the urine. The drug interaction and toxicity profiles aresimilar to that of methotrexate.

Mechanism of action

Like methotrexate, it is actively transported into tumor cells through reduced folate carriers and, in polyglutamated form, inhibits the synthesis of pyrimidine and purine-based nucletotides by disrupting folatedependent metabolic processes . In addition to DHFR, this pyrrolopyrimidine-based inhibitor binds tightly to thymidylate synthase and GAR transformylase.

Clinical Use

Pemetrexed is a novel multitarget antifolate used by the IV route for the treatment of advanced or metastatic nonsmall cell lung cancer and in combination with cisplatin in malignant pleural mesothelioma.

Nebenwirkungen

Patients on pemetrexed must take folate and vitamin B12 supplements to reduce the risk of bone marrow suppression (neutropenia, thrombocytopenia, and anemia) and GI side effects. Pretreatment with corticosteroids can reduce the risk of drug-induced skin rash. Pemetrexed has a half-life of 3.5 hours and is excreted primarily unchanged via the kidneys. Significant cross-resistance has been noted between pemetrexed and other pyrimidine and folate antagonists.

Pemetrexed Disodium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pemetrexed Disodium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 522)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
AFINE CHEMICALS LIMITED
+86-571-85134551 +86-18958018566
info@afinechem.com China 15079 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +86-15965530500
nickzhang@hangyubiotech.com China 9942 58
Hebei Ganmiao New material Technology Co., LTD
+86-17332992504
sales8@hbganmiao.com China 300 58
Wuhan JiyunZen Tech Co., Ltd.
+86-18062099985
Amyjiyunzen@yeah.net China 672 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21585 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 295 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29812 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 419 58
Shenzhen Excellent Biotech Co., Ltd.
13480692018
ramyan@ex-biotech.com CHINA 954 58

150399-23-8()Verwandte Suche:


  • n-[4-[2-(2-amino-4,7-dihydro-4-oxo-1h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid disodium salt
  • PEMETREXED DISODIUM(ALIMTA)
  • PEMETREXED DISODIUM 99%
  • PEMETREXED DISODIUM 2.5H2O
  • PEMETREXED DISODIUM FOR INJECTION
  • PEMETREXED DISODIUM FOR INJECTION BK-A-01
  • Pemetrexed Dinatrium
  • Alimt
  • N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium
  • Pemwtrexed Disodium
  • 2-[4-[2-(4-Amino-2-oxo-3,5,7-triazabicyclo[4.3.0]nona-3,8,10-trien-9-yl)ethyl]benzoyl]aminopentanedioic acid disodium salt
  • PeMetrexed disodiuM (LY-231514)
  • PEMETREXED DISODIUM 7 H2O
  • PeMetrexed (AliMta)
  • N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid SodiuM Salt
  • AliMta disodiuM
  • LY 231514 disodiuM
  • LY231514 disodiuM
  • LY-231514 disodiuM
  • disodiuM (2S)-2-{[4-(2-{2-aMino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid
  • Sodium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)
  • Pemetrexed phosphate
  • sodium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate
  • N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt Pemetrexed
  • Pemetrexed Disodium Salt
  • Two sodium for the United States and the United States
  • Pemetrexed Disodium ,≥99%
  • Pemetrexed disodium, a novel antifolate
  • Pemetrexed disodium USP/EP/BP
  • Pemetrexed Disodium(USFDA)
  • Sodium (4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate
  • PEMETREXED SODIUM
  • ALIMTA
  • LY-231514
  • Pemetrexed disodium
  • L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt (1:2)
  • N-4-2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo2,3-dpyrimidin-5-yl)ethylbenzoyl-L-glutamic acid disodium salt
  • Pemetrexed disodium, 10 mM in DMSO
  • PEMETREXED DISODIUM USP
  • Pemetrexed disodium salt - Bio-X ?
  • Pemetrexed disodium (LY231514 disodium
  • PeMetexed DisodiuM
  • 150399-23-8
  • 357166-90-4
  • 150339-23-8
  • C20H21N5O62Na
  • C20H19N5Na2O6
  • C20H33N5Na2O13
  • C20H19N5O62Na
  • LY-231514
  • Molecular Targeted Antineoplastic
  • All Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents
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