N-Methylacetamide synthesis
- Product Name:N-Methylacetamide
- CAS Number:79-16-3
- Molecular formula:C3H7NO
- Molecular Weight:73.09
1445-45-0
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593-51-1
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$21.00/100g
79-16-3
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$8.00/25g
Yield:79-16-3 100%
Reaction Conditions:
in methanol at 135; for 0.25 h;Microwave irradiation;
Steps:
General procedure for the preparation of acetamides 3a-3u (via microwave irradiation)
General procedure: To a solution of 1.5 eq trimethyl orthoacetate in 2 mL MeOH was added amine hydrochloride (0.0015 mol). After heating via microwave irradiation to 135°C for 15 minutes, the product was isolated by concentration in vacuo to give essentially pure acetamides. In general, these reactions were accompanied by an expected but slight increase in pressure - none exceeded the pressure limits of the instrument.
References:
Di Grandi, Martin J.;Bennett, Caitlin;Cagino, Kristen;Muccini, Arnold;Suraci, Corey;Saba, Shahrokh [Synthetic Communications,2015,vol. 45,# 22,p. 2601 - 2607] Location in patent:supporting information
127-06-0
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$5.67/25g
79-16-3
303 suppliers
$8.00/25g
