thioperamide maleate salt
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- CAS-Nr.
- 148440-81-7
- Englisch Name:
- thioperamide maleate salt
- Synonyma:
- MR-12842 maleate;Thioperamide maleate, H3 antagonist;N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1);MR-12842,inhibit,Thioperamide maleate,MR 12842,MR12842,Histamine Receptor,Inhibitor,Thioperamide
- CBNumber:
- CB91216162
- Summenformel:
- C15H24N4SC4H4O4
- Molgewicht:
- 0
- MOL-Datei:
- 148440-81-7.mol
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thioperamide maleate salt Eigenschaften
- storage temp.
- desiccated
under inert gas
- L?slichkeit
- H2O: >10mg/mL
- Aggregatzustand
- solid
- Farbe
- white
- Wasserl?slichkeit
- H2O: >10mg/mL
DMSO: 12mg/mL
ethanol: 3mg/mL
- InChI
- 1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
- InChIKey
- REZRBLGMJZZSID-BTJKTKAUSA-N
- SMILES
- OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3
thioperamide maleate salt Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Thioperamide (maleate) is a selective histamine H
3 receptor antagonist that crosses the blood-
brain barrier. This compound binds to rat cerebral cortical cells
in vitro with a pK
i value of 8.4 and inhibits histamine binding
in vivo with an ED
50 value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-
aminobutyric acid.
Verwenden
Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.
Biochem/physiol Actions
Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.
thioperamide maleate salt Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
thioperamide maleate salt Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 36)Lieferanten
148440-81-7()Verwandte Suche:
- MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
- N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
- 1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1)
- MR-12842 maleate
- MR-12842,inhibit,Thioperamide maleate,MR 12842,MR12842,Histamine Receptor,Inhibitor,Thioperamide
- Thioperamide maleate, H3 antagonist
- 148440-81-7
