ICA 069673

582323-16-8

CAS-Nr.: 582323-16-8

Englisch Name:: ICA 069673

Synonyma:: ICA 069673;ICA 069673 ，S0144;ICA069673;ICA-069673;ICA-069673 >=98% (HPLC);ICA-069673, 10 mM in DMSO;N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor

CBNumber:: CB92552603

Summenformel:: C11H6ClF2N3O

Molgewicht:: 269.63

MOL-Datei:: 582323-16-8.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 79

ICA 069673 Eigenschaften

Siedepunkt:: 358.9±37.0 °C(Predicted)

Dichte: 1.539±0.06 g/cm3(Predicted)

storage temp.: Sealed in dry,Room Temperature

L?slichkeit: DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)

Aggregatzustand: Powder

pka: 9.47±0.70(Predicted)

Farbe: White to off-white

InChI: 1S/C11H6ClF2N3O/c12-11-15-4-7(5-16-11)17-10(18)6-1-2-8(13)9(14)3-6/h1-5H,(H,17,18)

InChIKey: IIBSHMFXVWTQSJ-UHFFFAOYSA-N

SMILES: O=C(C1=CC=C(F)C(F)=C1)NC2=CN=C(Cl)N=C2

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

ICA 069673 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

ICA 069673 is a heteromeric K_v7 channel activator. It is selective for K_v7.2/7.3 over K_v7.3/7.5 (EC₅₀s = 0.69 and 14.3 μM, respectively) and also activates K_v7.4, K_v7.5, and heteromeric K_v7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Na_v1.5, and K_v7.1 cardiac ion channels (IC₅₀s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED₅₀s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

ICA 069673 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ICA 069673 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 79)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30203	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +8619957148339	market18@leapchem.com	China	24569	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11674	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9935	58
Aladdin Scientific		tp@aladdinsci.com	United States	57473	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58

ICA 069673
N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
ICA069673;ICA-069673
Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
ICA-069673 >=98% (HPLC)
Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide
ICA-069673, 10 mM in DMSO
ICA 069673 ，S0144
582323-16-8
C11H6ClF2N3O
Selective KCNQ2/Q3 potassium channel opener.

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