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2'-O-Methylcytidine

2'-O-Methylcytidine Struktur
2140-72-9
CAS-Nr.
2140-72-9
Englisch Name:
2'-O-Methylcytidine
Synonyma:
4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one;2'-OMe-C;2'-OMe-rC;2'-O-Me-rC;2′-0-Methylcytidine;OMe-rC;2'-OMe-Cr;2'-O-Me-dC;2'-OMe Cytidine;2'-OMe-cytidine
CBNumber:
CB9324099
Summenformel:
C10H15N3O5
Molgewicht:
257.24
MOL-Datei:
2140-72-9.mol

2'-O-Methylcytidine Eigenschaften

Schmelzpunkt:
252-253 C
Siedepunkt:
506.0±60.0 °C(Predicted)
Dichte
1.68±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
L?slichkeit
Soluble in DMSO.
pka
13.37±0.70(Predicted)
Aggregatzustand
Powder
Farbe
White to Off-white
PH
4.2
Optische Rotation
70.902° (C=0.01 g/ml, H2O)
maximale Wellenl?nge (λmax)
281 (pH 1);273 (EtOH)
Major Application
pharmaceutical
InChI
InChI=1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1
InChIKey
RFCQJGFZUQFYRF-ZOQUXTDFSA-N
SMILES
OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OC)[C@@H]1O
CAS Datenbank
2140-72-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36-24/25
WGK Germany  3
HS Code  29349990
Speicherklasse 11 - Combustible Solids

2'-O-Methylcytidine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon, making it an effective viral replication inhibitor. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways and may be able to bind to the response element on DNA, which could inhibit protein synthesis in cancer cells. It is an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50 = 3.8 μM). It inhibits HCV replication in a replicon assay (IC50 = 21.2 μM).

Chemische Eigenschaften

White powder

Verwenden

2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

2'-O-Methylcytidine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2'-O-Methylcytidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 297)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Yunbio Tech Co.,Ltd.
+86-010-60605551 +86-18046518538
yunbiochem@126.com China 321 58
HANGZHOU LEAP CHEM CO., LTD.
+86-571-87711850
market18@leapchem.com China 43333 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20122 58
HANGZHOU HAILAN CHEMICAL CO.,LTD.
+86-57156122185 +86-15967590394
sales@hailan-chem.com China 2991 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29640 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
Zhejiang ZETian Fine Chemicals Co. LTD
+8618957127338
stella@zetchem.com China 2994 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10403 58
Nanjing Baifuli Technology Co., Ltd.
+86-15335185688
sales@unisyn.cn CHINA 332 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58

2140-72-9()Verwandte Suche:


  • 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one
  • 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one
  • 4-azanyl-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidin-2-one
  • 2'-OMe Cytidine
  • 4-aMino-1-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-1,2-dihydropyriMidin-2-one
  • 2'-O-Methylcytidine, >=99%
  • 2''-(O-METHYL)-CYTIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM
  • 2'-O-Methylcytidineanhydrous
  • 2'-O-Methyl-D-cytidine
  • 2'-O-Methylcytidine, >98.0%(HPLC)
  • 2'-O-Methylcytidine>
  • 2'-O-Methylcytidine USP/EP/BP
  • 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-1,2-dihydropyrimidin-2-one
  • 2'-OMe-Cr
  • 2’-O-Methyl cytidine, RNA nucleoside Cm
  • 4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one
  • OMe-rC
  • 2'-O-Methylcytidine
  • 2'-OMe-cytidine
  • 2'-O-Me-dC
  • Cytidine, 2'-O-methyl-
  • 2'-O-Methyl-d3 Cytidine
  • 2'-Methoxycytidine
  • 2'-O-Methylcytidine
  • 2′-O-Methylcytidine - [M84857]
  • 2′-0-Methylcytidine
  • 2'-OMe-rC
  • 2'-O-Me-rC
  • 2'-OMe-C
  • 2140-72-9
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleoside Analogs
  • BioChemical
  • Biochemicals and Reagents
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Heterocycles
  • Nucleotides
  • Nucleosides, Nucleotides, Oligonucleotides
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides
  • Modified(deoxy)nucleoside
  • Nucleosides-2'-OMe Nucleosides
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