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(+/-)-trans-1,2-Diaminocyclohexane

(+/-)-trans-1,2-Diaminocyclohexane structure

CAS No.: 1121-22-8

Chemical Name:: (+/-)-trans-1,2-Diaminocyclohexane

Synonyms: TRANS-1,2-CYCLOHEXANEDIAMINE;Cyclohexanediamine;(±)-trans-1,2-Diaminocyclohexane;TIMTEC-BB SBB007639;trans-1,2-cyclohexyldiamine;trans-1,2-Cyclohexanedi;Oxaliplatin Impurity 16;(±)-trans-1,2-DiaminocycL;trans-1,2-Diaminocyclohex;trans-1,2-Cyclohexaneiamine

CBNumber:: CB0247786

Molecular Formula:: C6H14N2

Molecular Weight:: 114.19

MDL Number:: MFCD00063747

MOL File:: 1121-22-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:24:33

Product description	Number	Pack Size	Price
(±)-trans-1,2-Diaminocyclohexane 99%	270016	10ml	$39.8
(±)-trans-1,2-Diaminocyclohexane 99%	270016	50ml	$131
trans-1,2-Cyclohexanediamine >97.0%(GC)(T)	C1120	25mL	$38
trans-1,2-Cyclohexanediamine >97.0%(GC)(T)	C1120	250mL	$190
(±)-trans-1,2-Diaminocyclohexane	TRC-D416095-5G	5g	$78
More product size

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(+/-)-trans-1,2-Diaminocyclohexane Properties

Melting point	14-15 °C(lit.)
Boiling point	79-81 °C15 mm Hg(lit.)
Density	0.951 g/mL at 25 °C(lit.)
vapor pressure	0.4 mm Hg ( 20 °C)
refractive index	n20/D 1.489(lit.)
Flash point	156 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	9.94(at 20℃)
form	Liquid
color	Clear colorless to light yellow
Water Solubility	Soluble
Sensitive	Air Sensitive
BRN	506142
InChI	1S/C6H14N2/c7-5-3-1-2-4-6(5)8/h5-6H,1-4,7-8H2/t5-,6-/m1/s1
InChIKey	SSJXIUAHEKJCMH-WDSKDSINSA-N
SMILES	N[C@@H]1CCCC[C@H]1N
CAS DataBase Reference	1121-22-8(CAS DataBase Reference)
FDA UNII	37EKL250EE
NIST Chemistry Reference	trans-1,2-Cyclohexanediamine(1121-22-8)
EPA Substance Registry System	1,2-Cyclohexanediamine, (1R,2R)-rel- (1121-22-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

Safety Statements

26-36/37/39-45

RIDADR

UN 2735 8/PG 2

WGK Germany

10-34

TSCA

TSCA listed

HazardClass

PackingGroup

HS Code

29213000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

REACH Registrations

Active

NFPA 704

	1
3		0

(+/-)-trans-1,2-Diaminocyclohexane price More Price(67)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	270016	(±)-trans-1,2-Diaminocyclohexane 99%	1121-22-8	10ml	$39.8	2026-04-30	Buy
Sigma-Aldrich	270016	(±)-trans-1,2-Diaminocyclohexane 99%	1121-22-8	50ml	$131	2026-04-30	Buy
TCI Chemical	C1120	trans-1,2-Cyclohexanediamine >97.0%(GC)(T)	1121-22-8	25mL	$38	2026-04-30	Buy
TCI Chemical	C1120	trans-1,2-Cyclohexanediamine >97.0%(GC)(T)	1121-22-8	250mL	$190	2026-04-30	Buy
TRC	TRC-D416095-5G	(±)-trans-1,2-Diaminocyclohexane	1121-22-8	5g	$78	2026-06-03	Buy

Product number	Packaging	Price	Buy
270016	10ml	$39.8	Buy
270016	50ml	$131	Buy
C1120	25mL	$38	Buy
C1120	250mL	$190	Buy
TRC-D416095-5G	5g	$78	Buy

(+/-)-trans-1,2-Diaminocyclohexane Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

(±)-trans-1,2-Diaminocyclohexane was used in the synthesis of macrocyclic [3+3] hexa Schiff base. It was also employed in the synthesis of multidentate ligands, chiral auxiliaries and chiral stationary phases.

Uses

(^+)-trans-1,2-Diaminocyclohexane is employed in the synthesis of macrocyclic [3+3] hexa Schiff base. It also plays an important role in the preparation of multidentate ligands, chiral auxiliaries and chiral stationary phases. Further, it is used to prepare [2+2] macrocyclization by reacting with aliphatic dialdehydes. In addition to this, it acts as a chiral ligand, which finds application in asymmetric catalysis.

General Description

(±)-trans-1,2-Diaminocyclohexane was condensed with aliphatic dialdehydes to form [3+3] or [2+2] macrocyclization products.

Synthesis

286-18-0

1121-22-8

General procedure for the synthesis of trans-1,2-cyclohexanediamine from epoxycyclohexane (CAS:286-18-0): 1. Epoxycyclohexane (39.2 g, 0.4 mol) and 30% ammonia (1.0 mol) were added to a reaction flask. The reaction was stirred at room temperature for 1.5 hours until the solution gradually clarified, indicating completion of the reaction. 2. The reaction mixture was cooled to room temperature under reduced pressure to give a white solid. Add 35 g of water to completely dissolve the solid and then cool to 0°C. 3. Slowly add 50% aqueous sulfuric acid solution, controlling the temperature throughout the process not to exceed 30°C. After stirring, gradually heat to 80°C under reduced pressure to remove the water, the system gradually becomes viscous and solidified. Stop stirring and continue vacuuming for 4 hours. 4. The solid was removed and pulverized and continued to be dried under vacuum at 120°C for 12 h. Moisture was measured to be 0.22% by Karl Fischer titration. 5. in another reaction flask, add sodium hydroxide solution and heat to 40°C, add the above solid powder in batches, controlling the temperature not to exceed 50°C. After addition, raise the temperature to 60°C, stirring until complete clarification, the reaction was completed at pH 9-10. 6. Extraction and distillation with 1,2-dichloroethane gave 27.2 g of aziridine with a GC purity of 99.6% and a total yield of 70% in two steps. 7. Aziridine (27.2 g, 0.28 mol), 30% ammonia (0.48 mol) and inorganic boric acid (3.5 g, 56 mmol) were mixed and heated to 90-95°C for overnight reaction. 8. Upon completion of the reaction, trans-1,2-cyclohexanediamine was obtained by distillation under reduced pressure, which solidified after cooling to 28.1 g of white solid with a GC purity of 99.7% and a yield of 88%, no cis isomers were detected, and the HNMR spectrum was consistent with the literature.

Purification Methods

Purify and store the diamine as for the cis-isomer above as it is a strong base and becomes yellow on storage. [Beilstein 13 IV 1.]

References

[1] Bulletin de la Societe Chimique de France, 1956, p. 382,387,1827
[2] Patent: CN106631815, 2017, A. Location in patent: Paragraph 0013; 0014; 0015

(+/-)-trans-1,2-Diaminocyclohexane Preparation Products And Raw materials

Raw materials

7-Aza-bicyclo[4.1.0]heptane

Preparation Products

(1R,2R)-(-)-1,2-Diaminocyclohexane (1S,2S)-(+)-1,2-Diaminocyclohexane (1R,2R)-(+)-1,2-Diaminocyclohexane L-tartrate

(+/-)-trans-1,2-Diaminocyclohexane Suppliers

Global( 376)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3992	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8741	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5228	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Chongqing Soarwin Technology Co., Ltd	+86-15790943001	crystal@sorawin.cn	China	421	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Shanghai UCHEM Inc.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Chongqing Soarwin Technology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	60

View Lastest Price from (+/-)-trans-1,2-Diaminocyclohexane manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-05	(+/-)-trans-1,2-Diaminocyclohexane 1121-22-8	$20.00-141.00	25g	0.99	25kg	Shanghai UCHEM Inc.
2026-05-28	trans-1,2-Diaminocyclohexane 1121-22-8	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-01-04	trans-1,2-Diaminocyclohexane 1121-22-8			99.0%	100kg/month	Hangzhou ICH Biofarm Co., Ltd

(+/-)-trans-1,2-Diaminocyclohexane
1121-22-8
$20.00-141.00
0.99
Shanghai UCHEM Inc.

trans-1,2-Diaminocyclohexane
1121-22-8
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

trans-1,2-Diaminocyclohexane
1121-22-8
99.0%
Hangzhou ICH Biofarm Co., Ltd

(+/-)-trans-1,2-Diaminocyclohexane Spectrum

(+/-)-trans-1,2-Diaminocyclohexane(1121-22-8)¹HNMR (+/-)-trans-1,2-Diaminocyclohexane(1121-22-8)Raman (+/-)-trans-1,2-Diaminocyclohexane(1121-22-8)IR

1121-22-8((+/-)-trans-1,2-Diaminocyclohexane)Related Search:

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(S,S)-(+)-N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,2-CYCLOHEXANEDIAMINO-COBALT(II) 1,2-Diaminocyclohexane (1S)-TRANS-1,2-DIAMINOCYCLOHEXANE D-TARTRATE

1of4

(+/-)-TRANS-1,2-CYCLOHEXANEDIAMINE 1,2-Cyclohexanediamine, trans- trans-1,2-Cyclohexaneiamine Trans-(L)-1,2-Diaminecyclohexane trans-1,2-Diaminocyclohexane(Racemic) Diaminocyclohexane,trans-1,2- (n)-trans-1,2-cyclohexanediamine (n)-trans-1,2-diaminocyclohexane (+/-)-trans-1,2-Diaminocyclohexane 1,2-TRAMS-DIAMINOCYCLOHEXANE rel-(1R*,2R*)-1,2-Cyclohexanediamine rel-(1R*,2R*)-Cyclohexane-1,2-diamine (±)-trans-1,2-Diaminocyclohexane,98% trans-1,2-Cyclohexanedi (+/-)-trans-1,2-Diaminocyclohexane ,99% (±)-trans-1,2-Diaminocyclohexane,(±)-trans-1,2-Cyclohexanediamine (§1)-trans-1,2-Diaminocyclohexane, 98% (+/-)-trans-1,2-DiaMinocyclohexane 99% trans-1,2-Cyclohexanediamine (±)-trans-1,2-DiaminocycL trans-1,2-Diaminocyclohex trans-1,2-Cyclohexanediamine> 1,2-Cyclohexanediamine, (1R,2R)-rel- Trans-1,2-diaminocyclohexane -1，2- TIANFUCHEM-- 1121-22-8 -- (+/-)-trans-1,2-Diaminocyclohexane in stock TIMTEC-BB SBB007639 (±)-trans-1,2-Diaminocyclohexane (±)-trans-1,2-Diaminocyclohexane -trans-1,2-Diaminocyclohexane Oxaliplatin Impurity 16 (±)-trans-1,2-Diaminocyclohexane Cyclohexanediamine TRANS-1,2-CYCLOHEXANEDIAMINE trans-1,2-cyclohexyldiamine 1121-22-8 112-22-8 Polyamines Organic Building Blocks Nitrogen Compounds Building Blocks bc0001

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(+/-)-trans-1,2-Diaminocyclohexane

(+/-)-trans-1,2-Diaminocyclohexane Properties

SAFETY

Risk and Safety Statements

(+/-)-trans-1,2-Diaminocyclohexane price More Price(67)

(+/-)-trans-1,2-Diaminocyclohexane Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

General Description

Synthesis

Purification Methods

References

(+/-)-trans-1,2-Diaminocyclohexane Preparation Products And Raw materials

Raw materials

Preparation Products

(+/-)-trans-1,2-Diaminocyclohexane Suppliers

View Lastest Price from (+/-)-trans-1,2-Diaminocyclohexane manufacturers

(+/-)-trans-1,2-Diaminocyclohexane Spectrum

1121-22-8((+/-)-trans-1,2-Diaminocyclohexane)Related Search: