N-(Trifluoroacetyl)glycine
- CAS No.
- 383-70-0
- Chemical Name:
- N-(Trifluoroacetyl)glycine
- Synonyms
- (2,2,2-trifluoroacetyl)glycine;TFA-Gly;TFA-GLY-OH;TFA-GLYCINE;TRIFLUOROACETYL GLYCINE;n-(trifluoroacetyl)glycine;L- trifluoroacetyl glycine;glycine,N-(trifluoroacetyl)-;N-alpha-Trifluoracetyl-glycin;N-ALPHA-TRIFLUOROACETYL-GLYCINE
- CBNumber:
- CB0383547
- Molecular Formula:
- C4H4F3NO3
- Molecular Weight:
- 171.07
- MDL Number:
- MFCD00029784
- MOL File:
- 383-70-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-Trifluoroacetylglycine | T8416-28 | 500mg | $368 |
| N-Trifluoroacetylglycine | T8416-28 | 1g | $468 |
| N-Trifluoroacetylglycine | T8416-28 | 2.5g | $588 |
| N-Trifluoroacetylglycine | T8416-28 | 5g | $765 |
| Trifluoroacetyl glycine 99+% (HPLC) ≥99%(HPLC) | 242479 | 1g | $170 |
| More product size | |||
| Melting point | 120-121 °C |
|---|---|
| Boiling point | 291.6°C |
| Density | 1.534 |
| Flash point | 130°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, DMSO |
| form | Solid |
| pka | 2.99±0.10(Predicted) |
| color | White |
| InChI | InChI=1S/C4H4F3NO3/c5-4(6,7)3(11)8-1-2(9)10/h1H2,(H,8,11)(H,9,10) |
| InChIKey | IFAXXCBMQJNCCF-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CNC(C(F)(F)F)=O |
| CAS DataBase Reference | 383-70-0 |
| NIST Chemistry Reference | N-(Trifluoroacetyl)aminoacetic acid(383-70-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H302-H319 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
N-(Trifluoroacetyl)glycine price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | T8416-28 | N-Trifluoroacetylglycine | 383-70-0 | 500mg | $368 | 2026-06-04 | Buy |
| Usbiological | T8416-28 | N-Trifluoroacetylglycine | 383-70-0 | 1g | $468 | 2026-06-04 | Buy |
| Usbiological | T8416-28 | N-Trifluoroacetylglycine | 383-70-0 | 2.5g | $588 | 2026-06-04 | Buy |
| Usbiological | T8416-28 | N-Trifluoroacetylglycine | 383-70-0 | 5g | $765 | 2026-06-04 | Buy |
| Usbiological | 242479 | Trifluoroacetyl glycine 99+% (HPLC) ≥99%(HPLC) | 1g | $170 | 2026-06-03 | Buy |
N-(Trifluoroacetyl)glycine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
N-Trifluoroacetylglycine (cas# 383-70-0) is a compound useful in organic synthesis.
Definition
ChEBI: N-(trifluoroacetyl)glycine is an N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of trifluoroacetic acid. It is a N-acylglycine, a secondary carboxamide and a trifluoroacetamide.
Synthesis
383-63-1
56-40-6
383-70-0
The general procedure for the synthesis of 2-(2,2,2-trifluoroacetamido)acetic acid from ethyl trifluoroacetate and glycine was carried out as follows: the TFA-α-amino acid was prepared by the method reported in references [1,2] with slight modifications. First, triethylamine (33 mmol, 1.5 eq.) was added to a methanolic solution (22 mL) of glycine (22 mmol). after 5 min, ethyl trifluoroacetate (29 mmol, 1.3 eq.) was added and the reaction mixture was stirred for 24 h. The reaction was carried out by rotary evaporation. Upon completion of the reaction, the solvent was removed by rotary evaporation. The remaining residue was dissolved in water (35 mL) and acidified with concentrated hydrochloric acid (4 mL). After acidification, the mixture was stirred for 15 minutes and then extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and brine, and dried with anhydrous magnesium sulfate. After drying, filter and concentrate by rotary evaporation. If cured products (e.g., L-1a, D-1a, L-2a, D-2a, 3a, L-4a, D-4a to D-8a) are desired, they can be further dried overnight under high vacuum.
References
[1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 30, p. 8298 - 8309
[2] Organic Letters, 2018, vol. 20, # 18, p. 5877 - 5880
[3] Molecules, 2017, vol. 22, # 10,
[4] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788,15
[5] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788
N-(Trifluoroacetyl)glycine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3997 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 |
View Lastest Price from N-(Trifluoroacetyl)glycine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-06-26 | N-(Trifluoroacetyl)glycine
383-70-0
|
$1.00 | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-02-22 | N-(Trifluoroacetyl)glycine
383-70-0
|
1KG | 98.9% | 100 tons | Honest Joy Holdings Limited
|
-
- N-(Trifluoroacetyl)glycine
383-70-0
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- N-(Trifluoroacetyl)glycine
383-70-0
- $0.00
- 98.9%
- Honest Joy Holdings Limited
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