ChemicalBook >> CAS DataBase List >>N-Boc-Trans-4-Hydroxy-D-proline methyl ester
N-Boc-Trans-4-Hydroxy-D-proline methyl ester
- CAS No.
- 135042-17-0
- Chemical Name:
- N-Boc-Trans-4-Hydroxy-D-proline methyl ester
- Synonyms
- N-Boc-trans-D-Hyp-Ome;(2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;Boc-trans-D-Hyp-OMe;Boc-D-trans-Hyp-OMe;trans-Boc-D-Hpy-Ome;(Tert-Butoxy)Carbonyl D-trans-Hyp-OMe;Methyl (4S)-1-Boc-4-hydroxy-D-prolinate;Boc-trans-4-Hydroxy-D-proline Methyl ester;N-Boc-Trans-4-Hydroxy-D-Proline Methyl Este;(2R,4S)-N-Boc-4-hydroxyproline methyl ester
- CBNumber:
- CB21561519
- Molecular Formula:
- C11H19NO5
- Molecular Weight:
- 245.27
- MDL Number:
- MFCD09954932
- MOL File:
- 135042-17-0.mol
- MSDS File:
- SDS
Last updated:2026-07-26 20:01:20
| Product description | Number | Pack Size | Price |
| (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | FB142238 | 100g | $900 |
| (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | FB142238 | 50g | $900 |
| (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | FB142238 | 250g | $1297.5 |
| (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate ≥98% | CS-W018668 | 1g | $16 |
| (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate ≥98% | CS-W018668 | 5g | $22 |
| More product size | |||
| Melting point | 89-92 °C |
|---|---|
| Boiling point | 335.2±42.0 °C(Predicted) |
| Density | 1.216±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| pka | 14.27±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C11H19NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h7-8,13H,5-6H2,1-4H3/t7-,8+/m0/s1 |
| InChIKey | MZMNEDXVUJLQAF-JGVFFNPUSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)C[C@@H](O)C[C@@H]1C(OC)=O |
| CAS DataBase Reference | 135042-17-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| HS Code | 2933998090 |
N-Boc-Trans-4-Hydroxy-D-proline methyl ester price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FB142238 | (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | 135042-17-0 | 100g | $900 | 2026-06-04 | Buy |
| Biosynth | FB142238 | (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | 135042-17-0 | 50g | $900 | 2026-06-04 | Buy |
| Biosynth | FB142238 | (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | 135042-17-0 | 250g | $1297.5 | 2026-06-04 | Buy |
| ChemScene | CS-W018668 | (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate ≥98% | 135042-17-0 | 1g | $16 | 2026-06-04 | Buy |
| ChemScene | CS-W018668 | (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate ≥98% | 135042-17-0 | 5g | $22 | 2026-06-04 | Buy |
N-Boc-Trans-4-Hydroxy-D-proline methyl ester Chemical Properties,Uses,Production
Uses
N-Boc-Trans-4-Hydroxy-D-proline methyl ester is a valuable organic compound that could be used to synthesis 1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate.
Application
N-Boc-Trans-4-Hydroxy-D-proline methyl ester is mainly used as a chiral building block in drug development and organic synthesis, especially as a non-cleaving linker in the synthesis of antibody-drug conjugates (ADCs), and plays a key role in proteomics research, peptide synthesis and the development of complex bioactive molecules.
IC 50
Non-cleavable Linker
Synthesis of N-Boc-Trans-4-Hydroxy-D-proline methyl ester from (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride and Di-tert-butyl dicarbonate
N-Boc-Trans-4-Hydroxy-D-proline methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 174)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PRISUN PHARMATECH CO.,LTD | +86-021-54326183-8001 +86-18917565227 | prisun@prisunpharma.com | China | 215 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8618017249410 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
View Lastest Price from N-Boc-Trans-4-Hydroxy-D-proline methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER
135042-17-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER
135042-17-0
|
1KG | 98% | 100KG | Career Henan Chemical Co |
-
- N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER
135042-17-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER
135042-17-0
- $0.00
- 98%
- Career Henan Chemical Co
135042-17-0(N-Boc-Trans-4-Hydroxy-D-proline methyl ester)Related Search:
N-BOC-TRANS-4-CYANO-L-PROLINE
N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER
(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
N-Boc-trans-4-Hydroxy-L-proline methyl ester
N-Boc-cis-4-Hydroxy-L-proline methyl ester
BOC-D-HYP-OTBU
BOC-D-PRO-OME
N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER
METHYL-R-N-(METHOXY CARBONYL)-PROLINE ESTER
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1of4
N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER
N-Boc-Trans-4-Hydroxy-D-Proline Methyl Este
Boc-trans-D-Hyp-OMe
(2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate
(2R,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-Methyl ester (N-Boc-trans-4-Hydroxy-D-proline Methyl ester
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-
Boc-trans-4-Hydroxy-D-proline Methyl ester
N-tert-butoxycarbonyl-trans-4-hydroxy-D-proline Methyl ester
(2R,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
1-tert-butyl 2-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate
Methyl (4S)-1-Boc-4-hydroxy-D-prolinate
N-Boc-Trans-5-Hydroxy-D-Proline Methyl Ester
(2R,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl
Methyl (2R,4S)-1-Boc-4-hydroxypyrrolidine-2-carboxylate
(Tert-Butoxy)Carbonyl D-trans-Hyp-OMe
(2R,4S)-N-Boc-4-hydroxyproline methyl ester
Boc-D-trans-Hyp-OMe
(2R,4S)-N-Boc-trans-4-hydroxy-D-proline methyl ester
1-O-tert-butyl 2-O-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate
N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER (CAS NO.135042-17-0)
N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER USP/EP/BP
trans-Boc-D-Hpy-Ome
1-(1,1-Dimethylethyl) 2-methyl (2R,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylate
(2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate/N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER
1-(tert-Butyl) 2-methyl (2R,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylate
(2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
N-Boc-trans-D-Hyp-Ome
135042-17-0
