Glucagon Receptor Antagonist I
- CAS No.
- 438618-32-7
- Chemical Name:
- Glucagon Receptor Antagonist I
- Synonyms
- hGCGR Antagonist;Glucagon Receptor Antagonist I;Glucagon receptor antagonist-7;Glucagon receptor antagonists-7;Butanamide, N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-2-ethyl-;N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-ethylbutanamide
- CBNumber:
- CB23136786
- Molecular Formula:
- C20H30N2OS
- Molecular Weight:
- 346.53
- MDL Number:
- MFCD01920208
- MOL File:
- 438618-32-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Glucagon Receptor Antagonist I ≥99% | 21223 | 500μg | $82 |
| Glucagon Receptor Antagonist I ≥99% | 21223 | 1mg | $146 |
| Glucagon Receptor Antagonist I ≥99% | 21223 | 5mg | $524 |
| Glucagon Receptor Antagonist I ≥99% | 21223 | 500μg | $74 |
| Glucagon Receptor Antagonist I ≥99% | 21223 | 1mg | $132 |
Glucagon Receptor Antagonist I price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21223 | Glucagon Receptor Antagonist I ≥99% | 438618-32-7 | 500μg | $82 | 2026-04-30 | Buy |
| Cayman Chemical | 21223 | Glucagon Receptor Antagonist I ≥99% | 438618-32-7 | 1mg | $146 | 2026-04-30 | Buy |
| Cayman Chemical | 21223 | Glucagon Receptor Antagonist I ≥99% | 438618-32-7 | 5mg | $524 | 2026-04-30 | Buy |
| Cayman Chemical | 21223 | Glucagon Receptor Antagonist I ≥99% | 438618-32-7 | 500μg | $74 | 2024-03-01 | Buy |
| Cayman Chemical | 21223 | Glucagon Receptor Antagonist I ≥99% | 438618-32-7 | 1mg | $132 | 2024-03-01 | Buy |
Glucagon Receptor Antagonist I Chemical Properties,Uses,Production
Description
Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.
Uses
Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels[1].
References
[1] Qureshi SA, et al., A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes. 2004 Dec;53(12):3267-73. DOI:10.2337/diabetes.53.12.3267
Glucagon Receptor Antagonist I Preparation Products And Raw materials
Raw materials
Preparation Products
Glucagon Receptor Antagonist I Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Alinda Chemical Ltd. | +7 (495) 672-17-08 | sale@alinda.ru | Russia | 68136 | 55 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2720 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
View Lastest Price from Glucagon Receptor Antagonist I manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Glucagon Receptor Antagonist I
438618-32-7
|
$478.00-1720.00 | 10g | TargetMol Chemicals Inc. |
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- Glucagon Receptor Antagonist I
438618-32-7
- $478.00-1720.00
- TargetMol Chemicals Inc.
