Skepinone-L
- CAS No.
- 1221485-83-1
- Chemical Name:
- Skepinone-L
- Synonyms
- CS-1010;CBS3830;SKEPINONE;Skepinone-L;Skepinone-L, >=98%;Skepinone-L (CBS3830);Skepinone-L USP/EP/BP;Skepinone-L, 10 mM in DMSO;inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann
- CBNumber:
- CB52628399
- Molecular Formula:
- C24H21F2NO4
- Molecular Weight:
- 425.42
- MDL Number:
- MFCD22572738
- MOL File:
- 1221485-83-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Skepinone-L ≥98% | 16974 | 500μg | $54 |
| Skepinone-L ≥98% | 16974 | 1mg | $102 |
| Skepinone-L ≥98% | 16974 | 5mg | $418 |
| Skepinone-L ≥98% | 16974 | 10mg | $732 |
| Skepinone-L ≥98% | 16974 | 500μg | $49 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2922500090 | |||||||||
| NFPA 704 |
|
Skepinone-L price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16974 | Skepinone-L ≥98% | 1221485-83-1 | 500μg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 16974 | Skepinone-L ≥98% | 1221485-83-1 | 1mg | $102 | 2026-04-30 | Buy |
| Cayman Chemical | 16974 | Skepinone-L ≥98% | 1221485-83-1 | 5mg | $418 | 2026-04-30 | Buy |
| Cayman Chemical | 16974 | Skepinone-L ≥98% | 1221485-83-1 | 10mg | $732 | 2026-04-30 | Buy |
| Cayman Chemical | 16974 | Skepinone-L ≥98% | 1221485-83-1 | 500μg | $49 | 2024-03-01 | Buy |
Skepinone-L Chemical Properties,Uses,Production
Description
Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.
Uses
Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation.
target
p38-MAPK
References
[1]. koeberle, s c et al., skepinone-l is a selective p38 mitogen-activated protein kinase inhibitor. nature chemical biology, 2012, 8(2), 141-143.
Skepinone-L Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28509 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from Skepinone-L manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-02 | Skepinone-L
1221485-83-1
|
$32.00-72.00 | 99.76% | 10g | TargetMol Chemicals Inc. |
-
- Skepinone-L
1221485-83-1
- $32.00-72.00
- 99.76%
- TargetMol Chemicals Inc.
