Skepinone-L
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- $40 - $2525
- Product name: Skepinone-L
- CAS: 1221485-83-1
- MF: C24H21F2NO4
- MW: 425.42
- EINECS:
- MDL Number:MFCD22572738
- Synonyms:5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-;Skepinone-L, >=98%;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;Skepinone-L;2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one;CS-1010;SKEPINONE
68 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Arctom
- Cayman Chemical
- Chemcia Scientific
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 1mg
- 10mM*1mLinDMSO
- 500μg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 0.5G
- 10mM(in1mLDMSO)
- 1G
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 2.5G
- Manufactureraablocks
- Product numberAA009CBZ
- Product descriptionSkepinone-L
- Packaging1mg
- Price$46
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CBZ
- Product descriptionSkepinone-L
- Packaging2mg
- Price$56
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CBZ
- Product descriptionSkepinone-L
- Packaging5mg
- Price$78
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CBZ
- Product descriptionSkepinone-L
- Packaging10mg
- Price$118
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CBZ
- Product descriptionSkepinone-L
- Packaging25mg
- Price$196
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CBZ
- Product descriptionSkepinone-L
- Packaging50mg
- Price$284
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10383
- Product descriptionSkepinone-L 98%
- Packaging25MG
- Price$225
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10383
- Product descriptionSkepinone-L 98%
- Packaging25MG
- Price$225
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10383
- Product descriptionSkepinone-L 98%
- Packaging100MG
- Price$695
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10383
- Product descriptionSkepinone-L 98%
- Packaging100MG
- Price$695
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10383
- Product descriptionSkepinone-L 98%
- Packaging1G
- Price$2250
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10383
- Product descriptionSkepinone-L 98%
- Packaging1G
- Price$2250
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX5940
- Product descriptionSkepinone-L
- Packaging10mg
- Price$837
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX5940
- Product descriptionSkepinone-L
- Packaging1mg
- Price$199
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3824
- Product descriptionSkepinone-L
- Packaging10mg
- Price$160
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3824
- Product descriptionSkepinone-L
- Packaging5mg
- Price$287
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CBZ | Skepinone-L | 1mg | $46 | 2026-05-28 | Buy |
| aablocks | AA009CBZ | Skepinone-L | 2mg | $56 | 2026-05-28 | Buy |
| aablocks | AA009CBZ | Skepinone-L | 5mg | $78 | 2026-05-28 | Buy |
| aablocks | AA009CBZ | Skepinone-L | 10mg | $118 | 2026-05-28 | Buy |
| aablocks | AA009CBZ | Skepinone-L | 25mg | $196 | 2026-05-28 | Buy |
| aablocks | AA009CBZ | Skepinone-L | 50mg | $284 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10383 | Skepinone-L 98% | 25MG | $225 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10383 | Skepinone-L 98% | 25MG | $225 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10383 | Skepinone-L 98% | 100MG | $695 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10383 | Skepinone-L 98% | 100MG | $695 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10383 | Skepinone-L 98% | 1G | $2250 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10383 | Skepinone-L 98% | 1G | $2250 | 2026-05-27 | Buy |
| AK Scientific | X5940 | Skepinone-L | 10mg | $837 | 2021-12-16 | Buy |
| AK Scientific | X5940 | Skepinone-L | 1mg | $199 | 2021-12-16 | Buy |
| ApexBio Technology | A3824 | Skepinone-L | 10mg | $160 | 2026-05-06 | Buy |
| ApexBio Technology | A3824 | Skepinone-L | 5mg | $287 | 2021-12-16 | Buy |
Properties
Melting point :130-134°C
Boiling point :629.0±55.0 °C(Predicted)
Density :1.384±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.49±0.20(Predicted)
form :Solid
color :Light Yellow to Yellow
Boiling point :629.0±55.0 °C(Predicted)
Density :1.384±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.49±0.20(Predicted)
form :Solid
color :Light Yellow to Yellow
Safety Information
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Description
Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.More related product prices
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