Methyl 4-amino-3-hydroxybenzoate
- CAS No.
- 63435-16-5
- Chemical Name:
- Methyl 4-amino-3-hydroxybenzoate
- Synonyms
- V R;METHYL 4-AMINO-3-HYDROXYBENZOATE;METHYL-3-HYDROXY-4-AMINOBENZOATE;4-AMINO-3-HYDROXYBENZOIC ACID ETHYL ESTER;3-HYDROXY-4-AMINOBENZOIC ACID ETHYL ESTER;4-Amino-3-hydroxybenzoic acid methyl ester;METHYL 4-AMINO-3-HYDROXYBENZENECARBOXYLATE;3-Hydroxy-4-aminobenzoic acid methyl ester;63435-16-5 Methyl 4-amino-3-hydroxybenzoate;3-HYDROXY-4-AMINOBENZOIC ACID ETHYL ESTER 97%
- CBNumber:
- CB6217815
- Molecular Formula:
- C8H9NO3
- Molecular Weight:
- 167.16
- MDL Number:
- MFCD01320538
- MOL File:
- 63435-16-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| methyl 4-amino-3-hydroxybenzoate AldrichCPR | CDS014285 | 250mg | $77.9 |
| Methyl 4-Amino-3-hydroxybenzoate min. 98.0 % | A3639 | 5G | $147 |
| Methyl 4-Amino-3-hydroxybenzoate min. 98.0 % | A3639 | 25G | $441 |
| METHYL 4-AMINO-3-HYDROXYBENZOATE 97% | 64021 | 1G | $11 |
| METHYL 4-AMINO-3-HYDROXYBENZOATE 97% | 64021 | 5G | $35 |
| More product size | |||
| Melting point | 120-122°C |
|---|---|
| Boiling point | 364.5±27.0 °C(Predicted) |
| Density | 1.305±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | solid |
| pka | 8.94±0.10(Predicted) |
| color | Brown |
| BRN | 608716 |
| InChI | InChI=1S/C8H9NO3/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4,10H,9H2,1H3 |
| InChIKey | OCZXDVNSNDITBS-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(N)C(O)=C1 |
| CAS DataBase Reference | 63435-16-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Methyl 4-amino-3-hydroxybenzoate(63435-16-5) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2922500090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Methyl 4-amino-3-hydroxybenzoate price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS014285 | methyl 4-amino-3-hydroxybenzoate AldrichCPR | 63435-16-5 | 250mg | $77.9 | 2026-04-30 | Buy |
| TCI Chemical | A3639 | Methyl 4-Amino-3-hydroxybenzoate min. 98.0 % | 63435-16-5 | 5G | $147 | 2026-04-30 | Buy |
| TCI Chemical | A3639 | Methyl 4-Amino-3-hydroxybenzoate min. 98.0 % | 63435-16-5 | 25G | $441 | 2026-04-30 | Buy |
| AstaTech | 64021 | METHYL 4-AMINO-3-HYDROXYBENZOATE 97% | 63435-16-5 | 1G | $11 | 2026-04-30 | Buy |
| AstaTech | 64021 | METHYL 4-AMINO-3-HYDROXYBENZOATE 97% | 63435-16-5 | 5G | $35 | 2026-04-30 | Buy |
Methyl 4-amino-3-hydroxybenzoate Chemical Properties,Uses,Production
Uses
Methyl 4-amino-3-hydroxybenzoate is used as an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.
Synthesis
67-56-1
2374-03-0
63435-16-5
1. 4-Amino-3-hydroxybenzoic acid (5.0 g, 32.6 mmol) was slowly added dropwise to a mixture of 1.25 M HCl solution (100 mL) and methanol (100 mL) at 0 °C. 2. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature with continuous stirring overnight. 3. The reaction process was monitored by HPLC and it was found that there was still raw material left, so the mixture was continued to be stirred at room temperature for 48 hours. 4. After completion of the reaction, the solvent was removed by distillation under reduced pressure. 5. 5. The residue was treated with saturated aqueous sodium bicarbonate solution, followed by extraction of the aqueous phase with ethyl acetate (2×). 6. The organic extracts were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to dryness to afford the title compound methyl 4-amino-3-hydroxybenzoate (5.37 g, 97% yield) as a crystalline solid. 7. The molecular weight of the product was confirmed to be 168 (M+1)+ by low resolution mass spectrometry (LRMS) analysis.
References
[1] Patent: WO2013/68552, 2013, A1. Location in patent: Page/Page column 70
[2] Patent: WO2013/68554, 2013, A1. Location in patent: Page/Page column 80
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 10, p. 1257 - 1260
[4] Patent: EP1382607, 2004, A2. Location in patent: Page 43
[5] Organic and Biomolecular Chemistry, 2016, vol. 14, # 15, p. 3782 - 3786
Methyl 4-amino-3-hydroxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Shanghai Safer Pharmaceutical Technology Co., Ltd. | 021-31761238 | sales@saferph.com | CHINA | 897 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from Methyl 4-amino-3-hydroxybenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-15 | Methyl4-amino-3-hydroxybenzoate
63435-16-5
|
1KG | 98.3% | 100 tons | Honest Joy Holdings Limited
|
||
 |
2019-07-10 | Methyl 4-amino-3-hydroxybenzoate
63435-16-5
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- Methyl4-amino-3-hydroxybenzoate
63435-16-5
- $0.00
- 98.3%
- Honest Joy Holdings Limited
-
- Methyl 4-amino-3-hydroxybenzoate
63435-16-5
- $8.80
- 97%-99%
- Career Henan Chemical Co
