ChemicalBook >> CAS DataBase List >>Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)-

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)-

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- structure

CAS No.: 1013098-90-2

Chemical Name:: Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)-

Synonyms: PI3KαPI3Kα/mTOR-IN-1;PI3Kα/mTORIN1,PI3Kα/mTOR IN 1,PI-3Kα/mTOR-IN-1;Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)-

CBNumber:: CB63339703

Molecular Formula:: C16H18N6O

Molecular Weight:: 310.35

MDL Number:: MFCD31544429

MOL File:: 1013098-90-2.mol

MSDS File:: SDS

Last updated:2026-04-21 10:31:43

Product description	Number	Pack Size	Price
PI3Kα/mTOR-IN-1 99.30%	CS-7340	1mg	$1653
PI3Kα/mTOR-IN-1 >98%	AA01EO79	1mg	$1731
PI3KAlpha/mTOR-IN-1 98%	AD248375	1MG	$785
PI3KAlpha/mTOR-IN-1 98%	AD248375	5MG	$1545
PI3KAlpha/mTOR-IN-1 98%	AD248375	25MG	$3105

Request For Quotation

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- Properties

Boiling point	637.3±65.0 °C(Predicted)
Density	1.422±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	13.59±0.50(Predicted)
color	Off-white to light yellow

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-7340	PI3Kα/mTOR-IN-1 99.30%	1013098-90-2	1mg	$1653	2026-06-04	Buy
aablocks	AA01EO79	PI3Kα/mTOR-IN-1 >98%	1013098-90-2	1mg	$1731	2026-05-30	Buy
ACHEMBLOCK	AD248375	PI3KAlpha/mTOR-IN-1 98%	1013098-90-2	1MG	$785	2026-05-27	Buy
ACHEMBLOCK	AD248375	PI3KAlpha/mTOR-IN-1 98%	1013098-90-2	5MG	$1545	2026-05-27	Buy
ACHEMBLOCK	AD248375	PI3KAlpha/mTOR-IN-1 98%	1013098-90-2	25MG	$3105	2026-05-27	Buy

Product number	Packaging	Price	Buy
CS-7340	1mg	$1653	Buy
AA01EO79	1mg	$1731	Buy
AD248375	1MG	$785	Buy
AD248375	5MG	$1545	Buy
AD248375	25MG	$3105	Buy

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- Chemical Properties,Uses,Production

Uses

PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.

in vivo

PI3Kα/mTOR-IN-1 exhibits low HLM ER, but it is highly cleared in rat liver microsome (RLM) with ER of 0.88. PI3Kα/mTOR-IN-1 exhibits moderate clearance, moderate V_dss, T_1/2 of 0.9 h, and good oral bioavailability^[1].

IC 50

PI3Kα: 7 nM (IC₅₀, Cell Assay); PI3Kα: 12.5 nM (Ki); mTOR: 10.6 nM (Ki)

References

[1] Le PT, et al. Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5098-103. DOI:10.1016/j.bmcl.2012.05.100

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- synthesis

Synthesis of Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- from 1-Boc-pyrazole-4-boronic acid pinacol ester and 2-amino-6-bromo-8-cyclopentyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- Preparation Products And Raw materials

Raw materials

2-amino-6-bromo-8-cyclopentyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1-Boc-pyrazole-4-boronic acid pinacol ester

Preparation Products

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- Suppliers

Global( 10)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39040	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7775	56
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24955	58
Beijing Boorsen Biotechnology Co., Ltd	400-901-9800 18611424007	cis@bioss.com.cn	China	9185	58
Sangon Biotech (Shanghai) Co.,Ltd.	--	Sales@sangon.com	China	6710	58
Shanghai Amole Biotechnology Co., Ltd.	18017925202 18916960931	2596183085@qq.com	China	17238	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
BOC Sciences	65
MedChemexpress LLC	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
TargetMol Chemicals Inc.	58
Beijing Boorsen Biotechnology Co., Ltd	58
Sangon Biotech (Shanghai) Co.,Ltd.	58
Shanghai Amole Biotechnology Co., Ltd.	58

View Lastest Price from Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-21	PI3Kα/mTOR-IN-1 1013098-90-2	$393.00-1030.00		99.89%	10g	TargetMol Chemicals Inc.
	2026-04-21	PI3Kα/mTOR-IN-1 1013098-90-2	$393.00-1030.00		99.89%	10g	TargetMol Chemicals Inc.

PI3Kα/mTOR-IN-1
1013098-90-2
$393.00-1030.00
99.89%
TargetMol Chemicals Inc.

PI3Kα/mTOR-IN-1
1013098-90-2
$393.00-1030.00
99.89%
TargetMol Chemicals Inc.

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- Spectrum

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)-(1013098-90-2)¹HNMR

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- PI3Kα/mTOR-IN-1 PI3K&alpha PI3Kα/mTORIN1,PI3Kα/mTOR IN 1,PI-3Kα/mTOR-IN-1 1013098-90-2

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