ChemicalBook CAS DataBase List Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)-

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- synthesis

3synthesis methods

Product Name:Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)-
CAS Number:1013098-90-2
Molecular formula:C16H18N6O
Molecular Weight:310.35

552846-17-0 Synthesis

1-Boc-pyrazole-4-boronic acid pinacol ester

552846-17-0
228 suppliers
$11.00/1g

2-amino-6-bromo-8-cyclopentyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

934495-31-5
1 suppliers
inquiry

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)-

1013098-90-2
17 suppliers
inquiry

Yield:1013098-90-2 65%

Reaction Conditions:

with potassium carbonate;bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide at 120; for 0.166667 h;Microwave irradiation;

Steps:

5

Example 5. Preparation of 2-amino-8-cvclopentyl-6-(1 H-pyrazol-4-yl)-4-methylpyridof2,3-Qipyrimidin- 7(8H)-one (Compound 101 ); To a solution of 2-amino-6-bromo-8-cyclopentyl-4-methylpyrido[2,3-c(lpyrimidin-7(8/-/)-one (100 mg, 0.31 mmol), terf-butyl 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H-pyrazole-1-carboxy late ( 110 mg, 1.2 equiv), dichlorobis(triphenylphosphine)palladium(ll) (6.5 mg, 009 mmol), DMF (2 ml_) in a 10 mL microwave vial was added potassium carbonate (3 M, 0.8 ml_). The solution was degassed with N₂ for 10 min before being capped and heated in the microwave reactor for 10 min at 120 ⁰C. Once complete, the reaction was diluted with 1 N NaOH (10 mL) and EtOAc (50 mL). The EtOAc layer was washed with 3N HCI, dried over MgSO₄, filtered, and concentrated under reduced pressure. The crude product was submitted for chromatography purification, the title compound was obtained in (62.5 mg, 65% yield). LRMS: 311 (M+H)⁺.¹H NMR (DMSO-CC₆, 400 MHz): 8.26 (2H, bs), 8.13 (1 H, s), 7.09 (2H, bs), 6.04-5.99 (1 H, m), 2.59 (3H, s), 2.27-2.23 (2H₁ bm), 2.04 (2H, bm), 1.77-1.74 (2H, bm), 1.62 (2H, bm).

References:

WO2008/32162,2008,A1 Location in patent:Page/Page column 36-37

5600-21-5 Synthesis

5600-21-5
333 suppliers
$18.00/25g

1013098-90-2
17 suppliers
inquiry

References

1003-03-8 Synthesis

1003-03-8
236 suppliers
$10.00/1g

1013098-90-2
17 suppliers
inquiry

References

HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links | Privacy | Terms | Product Manufacturers | New Products
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)- synthesis