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ChemicalBook >> CAS DataBase List >>2'-O-(2-Methoxyethyl)-5-methyluridine

2'-O-(2-Methoxyethyl)-5-methyluridine

CAS No.
163759-49-7
Chemical Name:
2'-O-(2-Methoxyethyl)-5-methyluridine
Synonyms
2'-O-MOE-5-Me-rU;MOE-mrU;2'-O-MOE-Tr;2'-MOE-5-Me-rU;5-Me-2'-O-MOE U;2'-O-MOE-5-Me-U;2'-O-MOE-5-Me-U;5-Me-2'-O-MOE-Ur;5-Me-2'-O-MOE-Me-U;2'-MOE-5-Me-Uridine
CBNumber:
CB82510024
Molecular Formula:
C13H20N2O7
Molecular Weight:
316.31
MDL Number:
MFCD02682964
MOL File:
163759-49-7.mol
MSDS File:
SDS
Last updated:2026-05-28 04:44:49
Product description Number Pack Size Price
2'-O-(2-Methoxyethyl)-5-methyluridine M3539 200MG $61
2'-O-(2-Methoxyethyl)-5-methyluridine M3539 1G $204
1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 313732 250.00mg $28
1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 313732 1.00g $67
1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 313732 5.00g $272
More product size

2'-O-(2-Methoxyethyl)-5-methyluridine Properties

Melting point 115.5-116.5 °C
Density 1.41
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form Solid
pka 9.55±0.10(Predicted)
color Off-White
Stability Hygroscopic
InChI InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-10(21-4-3-20-2)9(17)8(6-16)22-12/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1
InChIKey NEVQCHBUJFYGQO-DNRKLUKYSA-N
SMILES OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1O
FDA UNII 9Q36I4D9VB

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

2'-O-(2-Methoxyethyl)-5-methyluridine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M3539 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7 200MG $61 2026-04-30 Buy
TCI Chemical M3539 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7 1G $204 2026-04-30 Buy
Matrix Scientific 313732 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 163759-49-7 250.00mg $28 2026-05-19 Buy
Matrix Scientific 313732 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 163759-49-7 1.00g $67 2026-05-19 Buy
Matrix Scientific 313732 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 163759-49-7 5.00g $272 2026-05-19 Buy
Product number Packaging Price Buy
M3539 200MG $61 Buy
M3539 1G $204 Buy
313732 250.00mg $28 Buy
313732 1.00g $67 Buy
313732 5.00g $272 Buy

2'-O-(2-Methoxyethyl)-5-methyluridine Chemical Properties,Uses,Production

Uses

2'-O-(2-Methoxyethyl)-5-methyluridine is a protected uridine derivative (U829910) and nucleoside used in the preparation of synthetic nucleic acids.

Application

2'-O-(2-Methoxyethyl)-5-methyluridine (2'-MOE-5-Methyluridine) is a uridine nucleoside that is a combination of amidite with 5-methyluridine. 2'-MOE-5-Methyluridine is an intermediate in the synthesis of oligonucleotides, which are synthesized from phosphoramidites. Its analog 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine is a potent compound used in research of RNA viruses, particularly hepatitis C virus and picornaviruses.

Synthesis

1.jpg
2,2'-Anhydro-5-methyluridine (195 g, 0.81 M), tris(2-methoxyethyl)borate (231 g, 0.98 M) and 2-methoxyethanol (1.2 L) were added to a 2 L stainless steel pressure vessel and placed in a pre-heated oil bath at 160°C. After heating for 48 hours at 155-160°C, the vessel was opened and the solution evaporated to dryness and triturated with methanol (200 mL). The residue was suspended in hot acetone (1 L). The insoluble salts were filtered, washed with acetone (150 mL) and the filtrate evaporated. The residue (280 g) was dissolved in CH3CN (600 mL) and evaporated. A silica gel column (3 kg) was packed in CH2Cl2/ acetone/methanol (20:5:3) containing 0.5% Et3NH. The residue was dissolved in CH2Cl2 (250 mL) and adsorbed onto silica (150 g) prior to loading onto the column. The product was eluted with the packing solvent to give product. Yield 160 g, 63%.

22423-26-3
109-86-4
163759-49-7
Synthesis of 2'-O-(2-Methoxyethyl)-5-methyluridine from 2,2'-Anhydro-5-methyluridine and 2-Methoxyethanol

2'-O-(2-Methoxyethyl)-5-methyluridine Preparation Products And Raw materials

Global( 129)Suppliers
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View Lastest Price from 2'-O-(2-Methoxyethyl)-5-methyluridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2'-O-MOE-5-Me-rU pictures 2026-05-11 2'-O-MOE-5-Me-rU
163759-49-7
10g TargetMol Chemicals Inc.
2'-O-MOE-methyl Uridine pictures 2025-10-22 2'-O-MOE-methyl Uridine
163759-49-7
5KG 98% 5000kg INNOBIO PHARM CO.,LTD
2'-O-(2-Methoxyethyl)-5-methyluridine pictures 2025-04-04 2'-O-(2-Methoxyethyl)-5-methyluridine
163759-49-7
1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2'-O-(2-Methoxyethyl)-5-methyluridine Spectrum

2'-O-(2-Methoxyethyl)-5-methyluridine 5-Me-2'-O-MOE U Uridine, 2'-O-(2-Methoxyethyl)-5-Methyl- 5-Me-2'-O-MOE Uridine 2'-O-(2-Methoxyethy)-5-methyluridine 2'-O-(2-Methoxyethyl)-5-Methyl-uridine, >97% 1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE 2'-O-MOE-5-Methyluridin 2'-O-MOE-Tr 2'-O-Methoxyethyl-thyminde 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 2'-MOE-5-Me-Uridine 2’-MOE-5-Methyluridine 5-Me-2'-O-MOE-Ur MOE-mrU 2'-MOE-5-Me-rU 2’-O-(2-Methoxyethy)-5-methyl uridine 2'-MOE-5-Methyluridine 2'-O-Methoxyethyl-thymine 5-Me-2'-O-MOE-Me-U 2'-o-Methoxyethyl-5-methyluridine 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 2'-O-MOE-5-Me-U 2'-O-MOE-5-Me-U 2'-O-MOE-methyl Uridine 2'-O-MOE-5-Me-rU 163759-49-7 Modified(deoxy)nucleoside Nucleosides-2'-O-MOE Nucleosides
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