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DMT-2′Fluoro-dU Phosphoramidite

DMT-2′Fluoro-dU Phosphoramidite structure

CAS No.: 146954-75-8

Chemical Name:: DMT-2′Fluoro-dU Phosphoramidite

Synonyms: DMT-2'-F-dU-CE Phosphoramidite;2‘-F-U amidite;2'-Fluoro-dU CEP;2’-F-dU Amidite;2’-F-rUPhosphoramidite;2'-F-U Phosphoramidite;2'-F-U Phosphoramidite;2'-F-dU Phosphoramidite;5'-O-DMT-2'-fluoro-dU-CE;5'-O-DMT-2'-F-dU-3'-CEDPA

CBNumber:: CB8500324

Molecular Formula:: C39H46FN4O8P

Molecular Weight:: 748.78

MDL Number:: MFCD11113919

MOL File:: 146954-75-8.mol

MSDS File:: SDS

Last updated:2026-07-21 16:59:09

Product description	Number	Pack Size	Price
DMT-2′Fluoro-dU Phosphoramidite configured for PerkinElmer, configured for Polygen	U211280	1G	$226
DMT-2′Fluoro-dU Phosphoramidite configured for (?KTA? and OligoPilot?)	U211250	1G	$241
DMT-2′Fluoro-dU Phosphoramidite configured for (?KTA^® and OligoPilot^®)	U211250	10 g	$549
DMT-2′Fluoro-dU Phosphoramidite configured for MerMade	U211240	1 g	$236
DMT-2′Fluoro-dU Phosphoramidite ≥99% (31P-NMR)	U211200	100g	$4510

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DMT-2′Fluoro-dU Phosphoramidite Properties

storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml
form	powder
pka	9.39±0.10(Predicted)
color	white to off-white
biological source	non-animal source (no BSE/TSE risk)
InChIKey	HQHQPAYRJJMYQX-YOKGOYKLNA-N
SMILES	N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F \|&1:8,10,36,51,r\|
UNSPSC Code	41116105
NACRES	NA.51

SAFETY

Risk and Safety Statements

WGK Germany	3
Storage Class	11 - Combustible Solids

DMT-2′Fluoro-dU Phosphoramidite price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	U211280	DMT-2′Fluoro-dU Phosphoramidite configured for PerkinElmer, configured for Polygen	146954-75-8	1G	$226	2026-04-30	Buy
Sigma-Aldrich	U211250	DMT-2′Fluoro-dU Phosphoramidite configured for (?KTA? and OligoPilot?)	146954-75-8	1G	$241	2026-04-30	Buy
Sigma-Aldrich	U211250	DMT-2′Fluoro-dU Phosphoramidite configured for (?KTA^® and OligoPilot^®)	146954-75-8	10 g	$549	2026-04-30	Buy
Sigma-Aldrich	U211240	DMT-2′Fluoro-dU Phosphoramidite configured for MerMade	146954-75-8	1 g	$236	2026-04-30	Buy
Sigma-Aldrich	U211200	DMT-2′Fluoro-dU Phosphoramidite ≥99% (31P-NMR)	146954-75-8	100g	$4510	2026-04-30	Buy

Product number	Packaging	Price	Buy
U211280	1G	$226	Buy
U211250	1G	$241	Buy
U211250	10 g	$549	Buy
U211240	1 g	$236	Buy
U211200	100g	$4510	Buy

DMT-2′Fluoro-dU Phosphoramidite Chemical Properties,Uses,Production

Uses

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA.

Definition

DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA

Synthesis

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine (3.00 g, 5.47 mmol) was dissolved in anhydrous dichloromethane (50 ml) under an argon atmosphere, N,N-diisopropylethylamine (0.55 ml,3.18 mmol), 1H-tetrazole (0.45 g, 6.45 mmol) and 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite (1.92 g, 6.36mmol) were added. And the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed, 5 percent aqueous sodium hydrogen carbonate solution (20 ml) was added to the reaction mixture to allow layer separation, and the organic layer was washed with saturated brine (20 ml). The organic layer was dried over sodium sulfate, the filtrate was concentrated and the obtained crude product was purified by silica gel chromatography (hexane:ethyl acetate=75:25 - 30/70(v/v), containing 3percent triethylamine). The object fractions were collected and concentratedto give DMT-2′Fluoro-dU Phosphoramidite (2.76 g, 67.3 percent).

References

[1] Patent: EP2816053, 2014, A1. Location in patent: Paragraph 0371
[2] Patent: US9371353, 2016, B2. Location in patent: Page/Page column 78
[3] DR. MUTHIAH MANOHARAN. Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs?[J]. Angewandte Chemie, 2011, 123 10: 2332-2336. DOI: 10.1002/ange.201006519

DMT-2′Fluoro-dU Phosphoramidite Preparation Products And Raw materials

Raw materials

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 2'-Deoxy-5'-O-DMT-2'-fluorouridine Tetrazole Dichloromethane N,N-Diisopropylethylamine

Preparation Products

DMT-2′Fluoro-dU Phosphoramidite Suppliers

Global( 198)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Allbiosyn Biotechnology Co.,Ltd.	+86-18666985712	info@allbiosyn.com	China	295	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14032	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2993	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9631	58

Supplier	Advantage
Allbiosyn Biotechnology Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Yunbio Tech Co.,Ltd.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from DMT-2′Fluoro-dU Phosphoramidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-21	DMT-2′Fluoro-dU Phosphoramidite 146954-75-8	$29.00		99.50%	10g	TargetMol Chemicals Inc.
2025-04-04	5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 146954-75-8		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-08-08	5'-O-DMT-2'-fluoro-dU-CE 146954-75-8		100mg	≥99%	20tons	Hefei Huana Biomedical Technology Co.,Ltd.

DMT-2′Fluoro-dU Phosphoramidite
146954-75-8
$29.00
99.50%
TargetMol Chemicals Inc.

5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
146954-75-8
98%
Henan Aochuang Chemical Co.,Ltd.

5'-O-DMT-2'-fluoro-dU-CE
146954-75-8
$0.00
≥99%
Hefei Huana Biomedical Technology Co.,Ltd.

146954-75-8(DMT-2′Fluoro-dU Phosphoramidite)Related Search:

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Uridine DMT-2′Fluoro-dU Phosphoramidite

1of4

2'-Fluoro-5'-O-DMT-2'-deoxyuridine-3'-CE-Phosphoramidite 5'-DMT-2'-F-rU Phosphoramidite DMT-2'-F-DU AMIDITE 0.25G, AB, SINGLE DMT-2'-F-dU Amidite 0.25g, 89, Single 2’-F-rUPhosphoramidite 5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-O-DMT-2'-F-dU-3'-CEDPA 2'-F-dU Phosphoramidite 2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine-3'-CED PhosphoraMidite DMT-2′Fluoro-dU Phosphoramidite 3-({[(2-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-5-(2,4-DIOXO-3H-PYRIMIDIN-1-YL)-4-FLUOROOXOLAN 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite 2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine Phosphoramidite 2'-Fluoro-dU CEP Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 5'-Dimethoxytrityl-deoxyUridine, 2'-fluoro-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite 2'-Fluoro-N2-Isobutyryl-5'-O-DMT-2'-Deoxyguanosine-3'-CE-Phosphoramidite 5'-DMTr-2'-F-3'-O-CEP-URIDINE 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit 2‘-F-U amidite DMT-2'-F-U Phosphoramidite DMT-2’-F-dU-CE Phosphoramidite 5'-O-DMT-2'-fluoro-dU-CE Inhibitor,Nucleoside Antimetabolite/Analog,DMT2′FluorodU Phosphoramidite,inhibit,DMT 2′Fluoro dU Phosphoramidite 5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite 2'-Fluoro Uridine Amidite 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile DMTr-2'-F-dU-3'-CE-Phosphoramidite 2’-F-dU Amidite 5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-CE-Phosphoramidite 5'-ODMT-2'-Fluoro uridine-3'-OCEPA 2'-F-U Phosphoramidite 2'-Fluoro-2'-deoxy Uridine CED Phosphoramidite 2'-F-5'-O-DMT-2'-dU-3'-CE-Phosphoramidite 5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite DMT-2'FLUORO-DU PHOSPHORAMIDITE Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite, 10 mM in DMSO 2'-F-U Phosphoramidite 5'-O-DMT-2'-Fluoro-dU-CE, 99%, ≤0.2%(K.F.) 2’-Fluoro-dU Phosphoramidite, 5'-O-DMT-2'-fluoro-2’-deoxyuridine-3'-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite, 2’-F-rU CE Phosphoramidite 2’-Fluoro-U-3-phosphoramidite 5’-O-DMTr-2’-Deoxy-2’-fluorouridine-3’-CED-phosphoramidite 2'-F-d-Uisophosphorusamide 2'-F-dU-3'-CE-phosphoramidite 2’-Deoxy-3’-O-DMTr-2’-fluoro-uridine 5’-rev-CE phosphoramidite Amidite impurity DMT-2'-F-dU-CE Phosphoramidite 2'-F-DU phosphorus amide monomer 146954-75-8 Amidite

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