3-CHLORO-6-METHOXYPYRIDAZINE
- CAS No.
- 1722-10-7
- Chemical Name:
- 3-CHLORO-6-METHOXYPYRIDAZINE
- Synonyms
- NSC 69819;NSC 522667;TIMTEC-BB SBB004124;SPECS AC-907/25014054;3-Chloro-6-methoxypyrazine;6-Chloro-3-methoxypyridazine;3-Methoxy-6-chloropyridazine;3-CHLORO-6-METHOXYPYRIDAZINE;3-Chloro-6-methoxy-1,2-diazine;pyridazine, 3-chloro-6-methoxy-
- CBNumber:
- CB9437764
- Molecular Formula:
- C5H5ClN2O
- Molecular Weight:
- 144.56
- MDL Number:
- MFCD00006467
- MOL File:
- 1722-10-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Chloro-6-methoxypyridazine 95% | 108596 | 5g | $111 |
| 3-Chloro-6-methoxypyridazine >97.0%(GC) | C2376 | 5g | $67 |
| 3-Chloro-6-methoxypyridazine >97.0%(GC) | C2376 | 25g | $265 |
| 3-Chloro-6-methoxypyridazine ≥95% | CS-W001168 | 5g | $9 |
| 3-Chloro-6-methoxypyridazine ≥95% | CS-W001168 | 25g | $18 |
| More product size | |||
| Melting point | 84-85 °C(lit.) |
|---|---|
| Boiling point | 285℃ |
| Density | 1.292 |
| Flash point | 126℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 0.74±0.10(Predicted) |
| color | White to Almost white |
| BRN | 118854 |
| InChI | InChI=1S/C5H5ClN2O/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3 |
| InChIKey | XBJLKXOOHLLTPG-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NN=C(OC)C=C1 |
| CAS DataBase Reference | 1722-10-7(CAS DataBase Reference) |
| FDA UNII | 4NE4MDH8HE |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-CHLORO-6-METHOXYPYRIDAZINE price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 108596 | 3-Chloro-6-methoxypyridazine 95% | 1722-10-7 | 5g | $111 | 2023-01-07 | Buy |
| TCI Chemical | C2376 | 3-Chloro-6-methoxypyridazine >97.0%(GC) | 1722-10-7 | 5g | $67 | 2026-04-30 | Buy |
| TCI Chemical | C2376 | 3-Chloro-6-methoxypyridazine >97.0%(GC) | 1722-10-7 | 25g | $265 | 2026-04-30 | Buy |
| ChemScene | CS-W001168 | 3-Chloro-6-methoxypyridazine ≥95% | 1722-10-7 | 5g | $9 | 2026-06-04 | Buy |
| ChemScene | CS-W001168 | 3-Chloro-6-methoxypyridazine ≥95% | 1722-10-7 | 25g | $18 | 2026-06-04 | Buy |
3-CHLORO-6-METHOXYPYRIDAZINE Chemical Properties,Uses,Production
Uses
3-Chloro-6-methoxypyridazine was used in the preparation of number of α-aryl-α-(pyridazin-3-yl)-acetonitriles.
Synthesis Reference(s)
The Journal of Organic Chemistry, 60, p. 1466, 1995 DOI: 10.1021/jo00110a059
General Description
3-Chloro-6-methoxypyridazine undergoes regioselective metallation using various lithium alkylamides, temperatures and solvents (THF and ether). It was lithiated using lithium 2,2,6,6-tetramethylpiperidide during the synthesis of minaprine.
Synthesis
141-30-0
124-41-4
1722-10-7
A methanolic solution of 0.5 M sodium methanolate (NaOMe/MeOH, 7.4 mL, 3.69 mmol) was slowly added dropwise to a solution of anhydrous tetrahydrofuran (12 mL) containing 3,6-dichloropyridazine (500 mg, 3.36 mmol), and the reaction mixture was stirred for 1 h at room temperature. Subsequently, the reaction was quenched by the addition of water. The reaction mixture was extracted with ethyl acetate and the organic phases were combined. The organic phase was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography to afford 6-methoxy-3-chloropyridazine (436 mg, 90% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ 4.12 (s, 3H), 6.98 (d, J = 9.2 Hz, 1H), 7.38 (d, J = 9.2 Hz, 1H); 13C NMR (100 MHz, CDCl3) δ 55.5 (d, J = 9.2 Hz, 1H). CDCl3) δ 55.2, 119.9, 130.6, 150.9, 164.2.
References
[1] Journal of Heterocyclic Chemistry, 2005, vol. 42, # 4, p. 509 - 513
[2] Patent: US2010/261727, 2010, A1. Location in patent: Page/Page column 31
[3] ACS Chemical Neuroscience, 2017, vol. 8, # 11, p. 2374 - 2380
[4] Journal of Heterocyclic Chemistry, 2013, vol. 50, # 5, p. 1165 - 1173
[5] Journal of the American Chemical Society, 1959, vol. 81, p. 6511,6512
3-CHLORO-6-METHOXYPYRIDAZINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23653 | 75 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 3-CHLORO-6-METHOXYPYRIDAZINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 3-Chloro-6-methoxypyridazine
1722-10-7
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2025-11-18 | 3-CHLORO-6-METHOXYPYRIDAZINE
1722-10-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2022-01-04 | 3-Chloro-6-methoxypyridazine
1722-10-7
|
1g | 98%minHPLC | 300kgs/month | Shanghai Rlavie Technology Co ltd |
-
- 3-Chloro-6-methoxypyridazine
1722-10-7
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 3-CHLORO-6-METHOXYPYRIDAZINE
1722-10-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-Chloro-6-methoxypyridazine
1722-10-7
- 98%minHPLC
- Shanghai Rlavie Technology Co ltd
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