AP26113
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AP26113 ??
- ?? ?
- 737.6±70.0 °C(Predicted)
- ??
- 1.29±0.1 g/cm3(Predicted)
- ?? ??
- Store at -20°C
- ???
- ≥26.45 mg/mL in DMSO; insoluble in H2O; ≥55.9 mg/mL in EtOH
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 9.27±0.20(Predicted)
- ??
- White to off-white
- CAS ??????
- 1197958-12-5
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
AP26113 C??? ??, ??, ??
?? ???
This potent ALK inhibitor (FW = 529.02 g/mol; CAS 1197958-12-5; Solubility: 45 mg/mL DMSO; <1 mg/mL H2O), also named 5-chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethyl- phosphinyl)phenyl]-2,4-pyrimidinediamine, inhibits wild type Lymphoma Kinase, or ALK (Ki = 0.62 nM) and overcomes crizotinib resistance in non- small cell lung cancers harboring the fusion oncogene EML4-ALK. Cells often develop the L1196M gatekeeper mutation within the kinase domain, a changes that renders them resistant to crizotinib, even at higher drug doses (1 μM). AP26113 is highly active against these resistant cancer cells, both in vitro and in vivo.AP26113 ?? ?? ? ???
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AP26113 ?? ??
???( 273)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 |
faithe@yan-xi.com | China | 5853 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 |
sales@sdperfect.com | China | 294 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29812 | 58 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 |
sales@tianpharm.com | CHINA | 304 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5906 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19936 | 58 |
| Jurong Coupling Biotechnology Co., Ltd. | 13656108824 |
coupling278191416@hotmail.com | CHINA | 184 | 58 |
| ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 |
tinayang@enbridgepharm.com | China | 307 | 58 |
| Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 |
sales@ryanchem.com | China | 169 | 58 |
AP26113 ?? ??:
Lenvatinib
Afatinib (BIBW 2992)
Vandetanib
Ceritinib
N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
Alectinib
ALK/IGF1R inhibitor
Crizotinib
NVP-TAE684
Lorlatinib (PF-06463922)
BKM-120
Capmatinib
Selumetinib
Cabozantinib
WZ4002
Dabrafenib
Dacomitinib (PF299804)
1110813-31-4