2,6-Dichloropurine
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2,6-Dichloropurine ??
- ???
- 185-195 °C (dec.) (lit.)
- ?? ?
- 310.62°C (rough estimate)
- ??
- 1.7265 (rough estimate)
- ???
- 1.6300 (estimate)
- ?? ??
- Keep in dark place,Sealed in dry,Room Temperature
- ???
- ?? ???
- ?? ?? (pKa)
- 5.22±0.20(Predicted)
- ??? ??
- ??? ??
- ??
- ???? ?????
- ???
- ??
- BRN
- 9354
- InChI
- InChI=1S/C5H2Cl2N4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11)
- InChIKey
- RMFWVOLULURGJI-UHFFFAOYSA-N
- SMILES
- N1C2C(=NC(Cl)=NC=2Cl)NC=1
- CAS ??????
- 5451-40-1(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-22 | ||
| ????? | 22-24/25-37/39-26-36 | ||
| ????(UN No.) | UN2811 | ||
| WGK ?? | 3 | ||
| ?? ?? | IRRITANT | ||
| HS ?? | 29349990 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral |
2,6-Dichloropurine C??? ??, ??, ??
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2,6-Dichloropurine is an important pharmaceutical intermediate. It is widely used in the preparation of purine nucleosides and purine nucleotides[1].??? ??
white to light yellow crystal powder??
2,6-Dichloropurine is used in the synthesis of 2,6-diamino-substituted purine derivatives as potential cardiomyogenesis inducing agents.Purification Methods
It can be recrystallised from 150 parts of boiling H2O and dried at 100o to constant weight. It is soluble in EtOAc. The HgCl2 salt separates from EtOH solution. UV: max 275nm ( 8.9K) at pH 1; and 280nm ( 8.5K) at pH 11 [Elion & Hitchings J Am Chem Soc 78 3508 1956, Schaeffer & Thomas J Am Chem Soc 80 3738 1958, Beaman & Robins J Appl Chem (London) 12 432 1962, Montgomery J Am Chem Soc 78 1928 1956]. [Beilstein 26 III/IV 1747.]2,6-Dichloropurine ?? ?? ? ???
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2,6-Dichloropurine ?? ??
???( 597)?? ??
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2,6-Dichloropurine ?? ??:
????? 1,2-?????? ??? ??
2',4'-Dichloroacetophenone
Dichloroethane
2,6-Dichloropurine-9--D-riboside,2,6-Dichloropurine-9-b-D-riboside,2,6-DICHLOROPURINE RIBO,2,6-DICHLOROPURINE-9-BETA-D-RIBOSIDE,2,6-DICHLOROPURINE RIBOSIDE
2,6-dichloro-9-(1-methylethyl)-9H-purine
2,6-DICHLOROPURINE-2'-DEOXYRIBOSIDE
2,6,8-TRICHLOROPURINE
2,6-Dichloro-7-methylpurine
DRB
Cefepime
2,6-DICHLORO-9-METHYL-9H-PURINE
2,6-dichloro-9-cyclopentyl-9H-purine
9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE
2,6-DICHLORO-9-(2-DEOXY-3,5,DI-O-(4-METHYLBENZOYL-BETA-D-ERYTHROPENTOFURANOSYL)-9H-PURINE)
2,6,8-TRICHLORO-7-METHYLPURINE