Tropine
Tropine ??
???
50-60 °C(lit.)
?? ?
233 °C(lit.)
??
1.045 g/mL at 25 °C(lit.)
???
1.4811 (estimate)
???
232-234°C
?? ??
Inert atmosphere,2-8°C
???
H2 O: 0.1 g/mL, ??
??? ??
??? ??
?? ?? (pKa)
3.80(at 15℃)
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???? ?? ???
??????(pH)
12 (100g/l, H2O, 20℃)
???
100g/L(20℃)
??
Hygroscopic
Merck
14,9781
BRN
80188
Henry's Law Constant
1.3×103 mol/(m3 Pa) at 25℃, Du et al. (2017)
InChI
1S/C8H15NO/c1-9-6-2-3-7(9)5-8(10)4-6/h6-8,10H,2-5H2,1H3/t6-,7+,8+
InChIKey
CYHOMWAPJJPNMW-JIGDXULJSA-N
SMILES
CN1[C@H]2CC[C@@H]1C[C@H](O)C2
LogP
-0.100 (est)
CAS ??????
120-29-6(CAS DataBase Reference)
NIST
Tropine(120-29-6)
EPA
8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, (3-endo)- (120-29-6)
??? ??
Xi,Xn
?? ???? ??
26/28-20/22
?????
22-24/25
????(UN No.)
1544
WGK ??
3
RTECS ??
YM3875000
F ??????
3
?? ?? ??
Irritant
TSCA
TSCA listed
?? ??
6.1(b)
????
III
HS ??
29399990
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11 - Combustible Solids
????(GHS):
?? ?:
Warning
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P- ??
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P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P271 ?? ?? ??? ? ?? ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
Tropine C??? ??, ??, ??
??? ??
white to slightly yellow crystalline powder
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Tropine is an oxidative product of Tropane, used to synthesize alkaloid derivatives.
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ChEBI: A derivative of tropane having a hydroxy group at the 3-position.
Purification Methods
Distil 3-tropanol in steam and crystallise it from Et2O or toluene/pet ether. It sublimes at 60o/0.1mm. Hygroscopic. The hydrochloride has m 280o (from EtOH/Et2O). [Beilstein 21 H 16, 21 I 197, 21 II 17, 21 III/IV 168, 21/1 V 219.]
Tropine ?? ?? ? ???
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Tropine ?? ??
???( 466)?? ??
Belgium 3
Canada 1
China 352
Czech Republic 1
Europe 1
France 4
Germany 13
India 15
Japan 4
Mexico 1
Russia 1
South Korea 1
Switzerland 4
Turkey 1
Ukraine 1
United Kingdom 12
United States 50
USA 1
Global 466
