???? ????
|
|
???? ???? ??
- ?? ?
- 270 °C(lit.)
- ??
- 0.95 g/mL at 25 °C(lit.)
- ???
- 0.3Pa at 20℃
- ???
- n
20/D 1.505(lit.)
- ???
- 228 °F
- ?? ??
- Inert atmosphere,Room Temperature
- ???
- ?????(?? ???), ???????, ???(?? ???)
- ??? ??
- ??
- ??
- ?? ??.
- ??
- ??? ??? ???? ??? ??-?? ?? ?? ??? ??? ?????.
- ?? ??
- ???
- ???? ??
- synthetic
- ???
- 66mg/L at 20℃
- JECFA Number
- 1465
- Henry's Law Constant
- 2.3×10-1 mol/(m3Pa) at 25℃, Dupeux et al. (2022)
- ???
- ???
- ?? ??
- ?? ? ?
- ??? ?? ??
- ??
- InChI
- 1S/C13H18O/c1-10(2)13-6-4-12(5-7-13)8-11(3)9-14/h4-7,9-11H,8H2,1-3H3
- InChIKey
- ZFNVDHOSLNRHNN-UHFFFAOYSA-N
- SMILES
- CC(C)c1ccc(CC(C)C=O)cc1
- LogP
- 3.4 at 35℃
- CAS ??????
- 103-95-7(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 38 | ||
| ????? | 26-36 | ||
| WGK ?? | 2 | ||
| RTECS ?? | MW4900000 | ||
| TSCA | TSCA listed | ||
| HS ?? | 29122990 | ||
| ???? ??? | 10 - Combustible liquids | ||
| Hazard Classifications | Aquatic Chronic 3 Skin Irrit. 2 Skin Sens. 1B |
||
| ?? | The acute oral LD50 value in rats was reported as 3*81 g/kg (Jenner, Hagan, Taylor, Cook & Fitzhugh, 1964). | ||
| ???? ?? | KE-24403 |
???? ???? C??? ??, ??, ??
??
2-Methyl-3-(p-isopropylphenyl) propionaldehyde has a strong, flowery odor. May be prepared by condensation of cuminic aldehyde and propionaldehyde followed by hydrogenation in the presence of a catalyst.??? ??
The commercially available racemate is a colorless to yellowish liquid with an intense floral odor reminiscent of Cyclamen europaeum (cyclamen, sowbread).Production. Two main processes are used for the industrial synthesis of cyclamen aldehyde:
1) Alkaline condensation of 4-isopropylbenzaldehyde and propanal results, via the aldol, in the formation of 2-methyl-3-(4-isopropylphenyl)-2-propenal. The unsaturated aldehyde is hydrogenated selectively to the saturated aldehyde in the presence of potassium acetate and a suitable catalyst, such as palladium–alumina:
2) Friedel–Crafts reaction of isopropylbenzene and 2-methylpropenal diacetate (methacrolein diacetate) in the presence of titanium tetrachloride/boron trifluoride etherate gives cyclamen aldehyde enolacetate, which is hydrolyzed to aldehyde:
Uses. Cyclamen aldehyde is an important component for obtaining special blossomnotes in perfume compositions, particularly the cyclamen type. Because of its fresh, floral aspect, it is also used as the top note in many other blossomfragrances.
??
Reported found in nutmeg and starfruit.??
Cyclamen Aldehyde is a very powerful, floral, green note used in many perfumery applications to blend into fresh, floral, green or ozonic/marine accords. It is an ingredient with growing use and importance in helping to build replacement accords for materials disappearing from the Perfumers’ palette. Cyclamen has good overall stability except in extremes of pH. It has good tenacity and substantivity and represents very good value for money in new creations.In addition to its use in numerous perfume compositions, cyclamen aldehyde is an intermediate for the preparation of fungicides and fungistatic substances.?? ??
By condensation of cuminic aldehyde and propionaldehyde followed by hydrogenation in the presence of a catalystSafety Profile
Moderately toxic by ingestion. A human skin irritant. See also ALDEHYDES. When heated to decomposition it emits acrid smoke and irritating fumes.Synthesis
Cyclamen aldehyde is synthesized from Cuminaldehyde plus Ropionaldehyde by condensation followed by selective hydrogenation and finally dehydrogenation of the Cyclamen alcohol to aldehyde.???? ???? ?? ?? ? ???
???
Tropine
p-t-??-α-?????????????
?????
2-Methylpropanedioic acid
??? ????
??(3?)??
???
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????(Ⅳ)
????????
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??????
trans-Cinnamaldehyde
4-?????-??-????????
3-o-???-2-??????????
?????? ?????
(Methoxymethyl)triphenylphosphonium chloride
????? ???
?? ??
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???( 237)?? ??
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Loxoprofen sodium
Loxoprofen
batridene
2-(4-TERT-BUTYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID
RARECHEM AQ BC 9085
1-[6-HYDROXY-4-(4-ISOPROPYLPHENYL)-3,6-DIMETHYL-4,5,6,7-TETRAHYDRO-2,1-BENZISOXAZOL-5-YL]ETHANONE
2-(4-TERT-BUTYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
RARECHEM AL BI 0264
AKOS B029667
AKOS B000951
1-[2-(4-ISOPROPYLPHENYL)CYCLOPROPYL]-1-ETHANONE
RARECHEM DK HD C009
ETHYL 2-(2-(4-TERT-BUTYLPHENYL)CYCLOPROPANECARBOXAMIDO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE