2-Hydroxybenzimidazole synthesis
- Product Name:2-Hydroxybenzimidazole
- CAS Number:615-16-7
- Molecular formula:C7H6N2O
- Molecular Weight:134.14
Yield:615-16-7 94%
Reaction Conditions:
with sulfated polyborate at 120; for 1.5 h;
Steps:
General procedure for the synthesis of (un)symmetrical 1,3-disubstituted ureas and 1H-benzimidazol-2(3H)-ones
General procedure: A mixture of amine (4 mmol or 2 mmol), or substituted OPDA (2 mmol), urea (2.4mmol), or N-phenylurea (2 mmol) and sulfated polyborate (10 wt%) was heated at 120°C in an oil bath. The reaction was monitored by thin layer chromatography. After completion of the reaction, the mixture was cooled to room temperature and quenched by water (5 mL); solid precipitated was filtered at vacuum pump, washed with water (3×5 mL), dried under vacuum and recrystallized from ethanol to afford the pure product.
References:
Rekunge, Deelip S.;Khatri, Chetan K.;Chaturbhuj, Ganesh U. [Tetrahedron Letters,2017,vol. 58,# 45,p. 4304 - 4307] Location in patent:supporting information
124-38-9
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95-54-5
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615-16-7
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![(2-aminophenyl)(1H-benzo[d][1,2,3]triazol-1-yl)methanone](/CAS/20180527/GIF/117576-29-1.gif)
117576-29-1
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615-16-7
407 suppliers
$8.00/10g
95-54-5
536 suppliers
$9.00/1g
615-16-7
407 suppliers
$8.00/10g