????????
|
|
???????? ??
- ???
- 160 °C (dec.)(lit.)
- ?? ?
- 230.35°C (rough estimate)
- ??
- 65 º (c=1,H2O)
- ??
- 0.6
- ?? ??
- 750kg/m3
- ???
- 63.5 ° (C=10, H2O)
- ?? ??
- Sealed in dry,Room Temperature
- ???
- 590g/l ????
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 12.06±0.60(Predicted)
- ??
- ???? ?????
- ??????(pH)
- 3.6 (10g/l, H2O, 20℃)
- ??
- wh. cryst. powd., pract. odorless
- ???? ??
- microbial
- ???
- 500g/L(20℃)
- Merck
- 14,4457
- BRN
- 83286
- ?? ??
- ???(???)
- ??? ?? ??
- ?? ????
????
- ??? ?? ??
- D-(+)-Glucono-1,5-lactone (90-80-2)
- InChI
- 1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1
- InChIKey
- PHOQVHQSTUBQQK-SQOUGZDYSA-N
- SMILES
- OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O
- LogP
- -2.38
- CAS ??????
- 90-80-2(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 21-36/38-46-62-63 | ||
| ????? | 24/25-53-36/37-26-25 | ||
| WGK ?? | 3 | ||
| RTECS ?? | LZ5184000 | ||
| F ?????? | 21 | ||
| TSCA | TSCA listed | ||
| HS ?? | 29322090 | ||
| ???? ??? | 11 - Combustible Solids | ||
| ?? ?? ??? | 90-80-2(Hazardous Substances Data) | ||
| ???? ?? | KE-17682 |
???????? C??? ??, ??, ??
????
? (1) ?? : ? ?? 1g? ? 10mL? ?? ?, ? ?? ????? ??? ?? ?? ????? ??.
??(2) ??? : ? ?? 0.5g? ??? ??????? ?? ??? ?, ? ?? 0.01N ?? 0.5mL? ???? ? ????? ??.
??(3) ??? : ? ?? 1g? ??? ??????? ?? ??? ?, ? ?? 0.01N ?? 0.5mL? ???? ? ????? ??.
??(4) ?? : ? ??? ?????? ?? ??? ?, ? ?? 4.0ppm ????? ??.
??(5) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 2.0ppm ????? ??.
??(6) ?? ?? ??? : ? ?? 0.5g? ? 10mL ? ???? 2mL? ??? 2?? ??? ?? ?? ??????? 5mL? ??? 4?? ??? ?? ?? ??? 20mL? ?? ? ? 5mL? ???? 2mL? ??? 1?? ?? ?, ?? ??～??? ??? ???? ?? ??.
????
? (1) ? ??? ???(1→50)? ????.
??(2) ? ??? ???(1→10) 1mL? ??????? 1??? ?? ?, ?? ??? ????.
??(3) ? ??? ???(1→10) 5mL? ??? 0.7mL ? ?? ??? ?????? 1mL? ??? ????? 30?? ???? ?? ?? ????? ??? ?? ? ??? ????. ??? ??? ?? ?? 10mL? ??? ??? ??? ??? ? ??? ?? ????. ?? ?? ????? ??? ?? ?? ??? ???? ??? ?? ? ?, ? ??? 196～202℃(??)??? ??.
??(4) ? ?? 2.5g? ?? ?? 25mL? ?? ?? ? ???? ??? ?, 
＝+60～+67°??.
???
? ? ??? ??? ?? ? 0.3g? ??? ?? 0.1N ???????? 30mL? ??? 20?? ??? ?? 0.1N ???? ??? ???? ????(??? : ???????? 3??).
0.1N ???????? 1mL ＝ 17.82mg C6H10O6
?????
? ? ??? ?????? 0.1% ????? ??.
??
Glucono delta-lactone (C6H10O6), molecular weight 178.14, is an inner ester of gluconic acid. Commonly named gluconolactone, other synonyms include D-gluconic acid delta-lactone, D-glucono- 1, 5-lactone, and D-delta-gluconolactone. Some of its earliest uses as a food ingredient were as a flavoring (e.g., sherbets) and to reduce fat absorption in doughnuts and cones. Glucono deltalactone tastes sweet initially and has a slightly acid-aftertaste.??? ??
Powder??
Geogard(R)Ultra is a synergistic blend of gluconolactone and sodium benzoate. This blend provides broad spectrum protection against product spoilage in a variety of personal care formulations. Product Data Sheet?? ??
Glucono delta-lactone is prepared commercially by the oxidation of glucose with bromine water.?? ??
Gluconolactone is a non-toxic component of the skin. It has anti-oxidant and free radical scavenging effects. Gluconolactone has antiaging and skin-firming properties. It acts as aβ-glucosidase inhibitor. Gluconolactone stimulates cellulase gene expression.Safety Profile
Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.Purification Methods
Crystallise Dglucono-lactone from ethylene glycol monomethyl ether and dry for 1hour at 110o. It can be freed from other sugars via a column of Celite and charcoal (750g of each, 90 x 7.5cm) which is washed with 0.01N formic acid until the pH of the wash is equal to that of the entering acid. The lactone is applied in H2O and eluted with 0.01N formic acid (7L), then eluted with 7.5% EtOH/0.01N formic acid (8L), then 15% EtOH/0.01N formic acid (8L) which removes pentose and isomaltose (the optical rotation of the eluates are used for sugar detection) and finally elution with aqueous formic acid provides glucolactone which is obtained by evaporating or freeze drying. Its solubility in H2O is 60% and 1% in EtOH. A solution in H2O is slightly acidic, and the lactone dissolves in an equivalent of aqueous NaOH to form sodium D-gluconate [527-07-1] M 218.1, m 2002 0 6o(dec), [ ] D 25 +12o (c 10, H2O), pK2 5 3.6. [cf p 553, Smith & Whelan Biochemical Preparations 10 127 1963, Beilstein 3 IV 1255.]???????? ?? ?? ? ???
???
Gluconate solution
?????????
??????
?2?????
??????
????
?????IRC-50
??? ??
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Palladium on Carbon
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???( 749)?? ??
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