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?????????
????????? ??? ???
?? ??:
117091-64-2
???:
?????????
???(??):
?????????
???:
Etoposide phosphate
???(??):
ETOPOPHOS;Etopofos;BMY 40481;ETOPOSIDE PHOSPHATE;ETOPOSIDE PHOSPHONATE;Etoposide 4'-Phosphate;ETOPOSIDEPHOSPHATE,ETOPOPHOS;Etoposide Phosphate (200 mg);Etoposide phosphate(BMY-40481);Etoposide phosphate≥ 98% (HPLC)
CBNumber:
CB5671214
???:
C29H33O16P
??? ??:
668.54
MOL ??:
117091-64-2.mol
MSDS ??:
SDS

????????? ??

?? ?
907.7±75.0 °C(Predicted)
??
1+-.0.1 g/cm3(Predicted)
?? ??
-20°C
?? ?? (pKa)
1.13±0.50(Predicted)
??? ??
Solid
??
White to off-white
???
Water: 125 mg/mL (186.97 mM)
InChIKey
LIQODXNTTZAGID-OCBXBXKTSA-N
SMILES
O=C1OC[C@]2([H])[C@@H](C3=CC4OCOC=4C=C3[C@@H](C3C=C(C(=C(C=3)OC)OP(O)(O)=O)OC)[C@]21[H])O[C@H]1[C@@H]([C@H]([C@]2([H])O[C@@H](OC[C@@]2([H])O1)C)O)O
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
WGK ?? WGK 3
HS ?? 2938909090
???? ??? 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 3
Carc. 1B
Repr. 2
????(GHS): Exclamation Mark (GHS07)Health Hazard (GHS08)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
H350 ?? ??? ? ?? (????? ?? ???? ???? ???? ??? ?? ????? ??? ???? ??) ??? ?? ?? 1A, 1B ??
H412 ??? ??? ?? ????? ??? ?? ????? ?? - ?? ?? 3 P273, P501
??????:
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P273 ???? ???? ???.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.

????????? C??? ??, ??, ??

??? ??

White crystalline powder

??

As a bioequivalent prodrug of the DNA topoisomerase II inhibitor Etoposide (E933750), Etoposide phosphate can be used in the treatment of a wide variety of hematological malignancies and solid tumors.

?? ??

Etoposide phosphate is a water-soluble prodrug of etoposide. Etoposide has played a very significant role in the treatment of various malignancies like germ cell tumors, Kaposi's sarcoma associated with AIDS, Hodgkin's disease, Non-Hodgkin's lymphoma, mycosis fungoides, acute myeloblasticleukemia, neuroblastoma, Ewing's sarcoma, paediatric rhabdomyosarcoma, ovarian carcinoma, small cell lung cancers, non-small cell lung cancers, gastric cancer and hepatomain the past two decades[1].

???

Etopophos (Bristol-Myers Squibb).

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???( 128)?? ??
??? ?? ??? ?? ?? ? ??
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