????? T
|
|
????? T ??
- ???
- 211-212 °C (decomp)
- ??
- 1.301g/cm3 at 20℃
- ???
- 0Pa at 25℃
- ?? ??
- Store below +30°C.
- ???
- ???: ???1mg/mL
- ?? ?? ??
- 49005
- ??? ??
- ??
- ??
- ???~???
- ???
- water: 5mg/mL
- BRN
- 3922452
- InChI
- InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
- InChIKey
- JADVWWSKYZXRGX-UHFFFAOYSA-M
- SMILES
- C1(=[N+](C)C2C=CC(C)=CC=2S1)C1C=CC(N(C)C)=CC=1.[Cl-]
- LogP
- 3.02 at 25℃ and pH7.98
- CAS ??????
- 2390-54-7(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????? | 24/25 | ||
|---|---|---|---|
| ????(UN No.) | 2811 | ||
| WGK ?? | 3 | ||
| TSCA | TSCA listed | ||
| ?? ?? | 6.1(b) | ||
| ???? | III | ||
| HS ?? | 32041300 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Dam. 1 Skin Sens. 1 |
||
| ???? ?? | KE-11178 |
????? T C??? ??, ??, ??
??? ??
yellow to ochre-yellow powder??
In 1959, Vassar and Culling first employed Thioflavin T (ThT) for the fluorescence imaging of amyloid plaques, revealing its potential for histological staining. In 1993, LeVine standardized the method for quantifying fibril formation using ThT, providing a simple fluorescence-based approach for studying protein folding and aggregation kinetics[1].??
Textile dyeing, fluorescent sign paints, in combination with green or blue pigments to produce brilliant greens, phosphotungstic pigments.?? ??
Upon binding to amyloid fibrils, Thioflavin T (ThT) exhibits a significant increase in fluorescence intensity, making it a common tool in research on protein aggregation-related diseases such as Alzheimer's disease and Parkinson's disease. The figure below shows the result of ThT staining[3].
?? ??
4-(6-Methyl-2,3-dihydrobenzo[d]thiazol-2-yl)benzenaminewith methanol and hydrochloric acid or sulfuric acid, at 160 ~ 170 ℃ methylation under pressure.?? ??
Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization.Purification Methods
Crystallise the chloride from *benzene/EtOH (1:1). [Beilstein 27 III/IV 5052.]????? T ?? ?? ? ???
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?? ??
????? T ?? ??
???( 360)?? ??
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