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????????7 ??
- ?? ?
- 705.4±60.0 °C(Predicted)
- ??
- 1+-.0.06 g/cm3(Predicted)
- ?? ??
- Sealed in dry,Room Temperature
- ???
- DMF:30.0(Max Conc. mg/mL);78.24(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.3(Max Conc. mM)
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 4.59±0.23(Predicted)
- ??
- White to off-white
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- [α]/D -35 to -27°, c =1 in methanol
- InChIKey
- DOBNVUFHFMVMDB-BEFAXECRSA-N
- SMILES
- OC(CCC(N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@H](C(O)=O)C)=O)=O
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- ?? ? ???? ?? (GHS)
| WGK ?? | WGK 3 | ||
|---|---|---|---|
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | STOT RE 1 STOT SE 3 |
| ????(GHS): |
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| ?? ?: | Warning | ||||||||||||||||||||||||||||
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????????7 C??? ??, ??, ??
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Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.????????7 ?? ?? ? ???
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???( 141)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Sinco Pharmachem (ShenZhen) R&D Co., Ltd. | +undefined18603013401 |
jack.lin@sincopharmachem.com | China | 10000 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14332 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19936 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30224 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 |
sales@huarongpharm.com | CHINA | 3148 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 |
dj@sgtlifesciences.com | China | 12373 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 |
market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; |
support@targetmol.com | United States | 39037 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 |
product@acmec-e.com | China | 33324 | 58 |
????????7 ?? ??:
Sacubitril Impurity 72
Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate
(2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-
(2R,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
Sacubitril Impurity 3
Sacubitril Impurity 19
Sacubitril Impurity 23
((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
Sacubitril Impurity 21
Sacubitril Impurity 6
Sacubitril Impurity 7
Sacubitril Impurity 5
Sacubitril Impurity 20
Sacubitril Impurity 24 HCl
Sildenafil EP Impurity G
Sacubitril Impurity 8