N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
![N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE price.](/CAS/GIF/853625-60-2.gif)
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- $25 - $1900
- Product name: N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
- CAS: 853625-60-2
- MF: C24H20N4O4S
- MW: 460.51
- EINECS:
- MDL Number:MFCD10687099
- Synonyms:N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE;SECINH3;N-(4-(5-(benzo[d][1,3]dioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide;3]dioxol-5-yl)-3-methoxy-1H-1;4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide;N-(4-(5-(benzo[d][1;CS-2379;Acetamide, N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)-
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Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 1G
- Manufactureraablocks
- Product numberAA00369F
- Product descriptionN-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide 99%
- Packaging1mg
- Price$25
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00369F
- Product descriptionN-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide 99%
- Packaging5mg
- Price$34
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00369F
- Product descriptionN-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide 99%
- Packaging10mg
- Price$65
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00369F
- Product descriptionN-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide 99%
- Packaging25mg
- Price$98
- Updated2026-05-28
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- ManufacturerACHEMBLOCK
- Product numberS87314
- Product descriptionSecinH3 98%
- Packaging100MG
- Price$200
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS87314
- Product descriptionSecinH3 98%
- Packaging100MG
- Price$200
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS87314
- Product descriptionSecinH3 98%
- Packaging1G
- Price$995
- Updated2026-05-25
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- ManufacturerACHEMBLOCK
- Product numberS87314
- Product descriptionSecinH3 98%
- Packaging1G
- Price$995
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3811CE
- Product descriptionSecinH3
- Packaging5mg
- Price$257
- Updated2021-12-16
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- ManufacturerAmbeed
- Product numberA923399
- Product descriptionSecinH3 98+%
- Packaging25mg
- Price$124
- Updated2021-12-16
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- ManufacturerAmbeed
- Product numberA923399
- Product descriptionSecinH3 98+%
- Packaging50mg
- Price$162
- Updated2021-12-16
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- ManufacturerAmbeed
- Product numberA923399
- Product descriptionSecinH3 98+%
- Packaging5mg
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA923399
- Product descriptionSecinH3 98+%
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7207
- Product descriptionSecinH3
- Packaging5mg
- Price$116
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7207
- Product descriptionSecinH3
- Packaging10mg
- Price$196
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7207
- Product descriptionSecinH3
- Packaging25mg
- Price$378
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00369F | N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide 99% | 1mg | $25 | 2026-05-28 | Buy |
| aablocks | AA00369F | N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide 99% | 5mg | $34 | 2026-05-28 | Buy |
| aablocks | AA00369F | N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide 99% | 10mg | $65 | 2026-05-28 | Buy |
| aablocks | AA00369F | N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide 99% | 25mg | $98 | 2026-05-28 | Buy |
| ACHEMBLOCK | S87314 | SecinH3 98% | 100MG | $200 | 2026-05-25 | Buy |
| ACHEMBLOCK | S87314 | SecinH3 98% | 100MG | $200 | 2026-05-27 | Buy |
| ACHEMBLOCK | S87314 | SecinH3 98% | 1G | $995 | 2026-05-25 | Buy |
| ACHEMBLOCK | S87314 | SecinH3 98% | 1G | $995 | 2026-05-27 | Buy |
| AK Scientific | 3811CE | SecinH3 | 5mg | $257 | 2021-12-16 | Buy |
| Ambeed | A923399 | SecinH3 98+% | 25mg | $124 | 2021-12-16 | Buy |
| Ambeed | A923399 | SecinH3 98+% | 50mg | $162 | 2021-12-16 | Buy |
| Ambeed | A923399 | SecinH3 98+% | 5mg | $73 | 2021-12-16 | Buy |
| Ambeed | A923399 | SecinH3 98+% | 10mg | $95 | 2021-12-16 | Buy |
| ApexBio Technology | B7207 | SecinH3 | 5mg | $116 | 2026-05-06 | Buy |
| ApexBio Technology | B7207 | SecinH3 | 10mg | $196 | 2026-05-06 | Buy |
| ApexBio Technology | B7207 | SecinH3 | 25mg | $378 | 2026-05-06 | Buy |
Properties
storage temp. :Inert atmosphere,2-8°C
solubility :DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.3 mg/ml
form :White powder solid.
color :White to off-white
InChI :1S/C24H20N4O4S/c1-30-24-26-23(16-7-12-20-21(13-16)32-15-31-20)28(27-24)18-10-8-17(9-11-18)25-22(29)14-33-19-5-3-2-4-6-19/h2-13H,14-15H2,1H3,(H,25,29)
InChIKey :QPGYAMIHXLCFTJ-UHFFFAOYSA-N
SMILES :S(CC(=O)Nc2ccc(cc2)[n]3nc(nc3c4cc5c(cc4)OCO5)OC)c1ccccc1
solubility :DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.3 mg/ml
form :White powder solid.
color :White to off-white
InChI :1S/C24H20N4O4S/c1-30-24-26-23(16-7-12-20-21(13-16)32-15-31-20)28(27-24)18-10-8-17(9-11-18)25-22(29)14-33-19-5-3-2-4-6-19/h2-13H,14-15H2,1H3,(H,25,29)
InChIKey :QPGYAMIHXLCFTJ-UHFFFAOYSA-N
SMILES :S(CC(=O)Nc2ccc(cc2)[n]3nc(nc3c4cc5c(cc4)OCO5)OC)c1ccccc1
Safety Information
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Description
SecinH3 is a cell-permeable triazolo compound that acts as a Sec7 domain-binding (Kd ≤250 nM for Sec7 from human cytohesins 1-3), selective antagonist against cytohesin family small nucleotide exchange factors, or GEFs (IC50 ≤5.6 μM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues). SecinH3 inhibits large GEFs only at much higher concentrations (IC50 ≥65 μM in GDP/GTP exchange assays using hEFA6-S7 and yGea2-S7) and exhibits little activity against a panel of 10 commonly studied kinases or hSosII. SecinH3 was shown to effectively inhibit insulin signaling both in HepG2 cells in vitro and in Drosophila and mice in vivo. SecinH3 is an inhibitor of cytohesin-1, cytohesin-2 and GRP1.Related product price
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