MIF Antagonist, ISO-1
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- $11 - $3475
- Product name: MIF Antagonist, ISO-1
- CAS: 478336-92-4
- MF: C12H13NO4
- MW: 235.24
- EINECS:-0
- MDL Number:MFCD22376813
- Synonyms:MIF Antagonist, ISO-1;Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate;MIF Antagonist;4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester;ISO-1 (ISO 1;ISO 1;ISO1;MIF ANTAGONIST;5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester;2-[3-(4-Hydroxyphenyl)-4,5-dihydroisoxazol-5-yl]acetic Acid Methyl Ester
86 prices
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Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Thermo Scientific Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 25mg
- 50.00mg
- 50mg
- 100.00mg
- 100mg
- 250.00mg
- 250mg
- 0.5g
- 50
- 500mg
- 1G
- 5g
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 10mM(1mLinDMSO)
- Manufactureraablocks
- Product numberAA00DB3M
- Product descriptionISO-1 98%
- Packaging1mg
- Price$11
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB3M
- Product descriptionISO-1 98%
- Packaging5mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB3M
- Product descriptionISO-1 98%
- Packaging10mg
- Price$25
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB3M
- Product descriptionISO-1 98%
- Packaging50mg
- Price$65
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB3M
- Product descriptionISO-1 98%
- Packaging25mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB3M
- Product descriptionISO-1 98%
- Packaging250mg
- Price$170
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB3M
- Product descriptionISO-1 98%
- Packaging100mg
- Price$101
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberU109060
- Product descriptionMethyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 98.00%
- Packaging100MG
- Price$150
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU109060
- Product descriptionMethyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 98.00%
- Packaging1G
- Price$680
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number6540AB
- Product descriptionMethyl2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate
- Packaging5g
- Price$2500
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA128540
- Product descriptionISO-1 98+%
- Packaging25mg
- Price$256
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA128540
- Product descriptionISO-1 98+%
- Packaging50mg
- Price$333
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA128540
- Product descriptionISO-1 98+%
- Packaging5mg
- Price$89
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA128540
- Product descriptionISO-1 98+%
- Packaging10mg
- Price$151
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0002669
- Product descriptionMETHYL-2-(3-(4-HYDROXYPHENYL)-4,5-DIHYDROISOXAZOL-5-YL)ACETATE 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0002669
- Product descriptionMETHYL-2-(3-(4-HYDROXYPHENYL)-4,5-DIHYDROISOXAZOL-5-YL)ACETATE 95.00%
- Packaging5MG
- Price$504.96
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00DB3M | ISO-1 98% | 1mg | $11 | 2026-05-28 | Buy |
| aablocks | AA00DB3M | ISO-1 98% | 5mg | $19 | 2026-05-28 | Buy |
| aablocks | AA00DB3M | ISO-1 98% | 10mg | $25 | 2026-05-28 | Buy |
| aablocks | AA00DB3M | ISO-1 98% | 50mg | $65 | 2026-05-28 | Buy |
| aablocks | AA00DB3M | ISO-1 98% | 25mg | $38 | 2026-05-28 | Buy |
| aablocks | AA00DB3M | ISO-1 98% | 250mg | $170 | 2026-05-28 | Buy |
| aablocks | AA00DB3M | ISO-1 98% | 100mg | $101 | 2026-05-28 | Buy |
| ACHEMBLOCK | U109060 | Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 98.00% | 100MG | $150 | 2026-05-27 | Buy |
| ACHEMBLOCK | U109060 | Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 98.00% | 1G | $680 | 2026-05-27 | Buy |
| AK Scientific | 6540AB | Methyl2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate | 5g | $2500 | 2021-12-16 | Buy |
| Ambeed | A128540 | ISO-1 98+% | 25mg | $256 | 2021-12-16 | Buy |
| Ambeed | A128540 | ISO-1 98+% | 50mg | $333 | 2021-12-16 | Buy |
| Ambeed | A128540 | ISO-1 98+% | 5mg | $89 | 2021-12-16 | Buy |
| Ambeed | A128540 | ISO-1 98+% | 10mg | $151 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0002669 | METHYL-2-(3-(4-HYDROXYPHENYL)-4,5-DIHYDROISOXAZOL-5-YL)ACETATE 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0002669 | METHYL-2-(3-(4-HYDROXYPHENYL)-4,5-DIHYDROISOXAZOL-5-YL)ACETATE 95.00% | 5MG | $504.96 | 2021-12-16 | Buy |
Properties
Melting point :114 °C
Boiling point :365.0±48.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO.
pka :9.22±0.30(Predicted)
form :Light yellow crystalline solid.
color :Off-white
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI :InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3
InChIKey :AIXMJTYHQHQJLU-UHFFFAOYSA-N
SMILES :O1C(CC(OC)=O)CC(C2=CC=C(O)C=C2)=N1
Boiling point :365.0±48.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO.
pka :9.22±0.30(Predicted)
form :Light yellow crystalline solid.
color :Off-white
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI :InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3
InChIKey :AIXMJTYHQHQJLU-UHFFFAOYSA-N
SMILES :O1C(CC(OC)=O)CC(C2=CC=C(O)C=C2)=N1
Safety Information
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Description
Macrophage migration inhibitory factor (MIF) is a regulator of inflammation that also has roles in cancer and autoimmune diseases. MIF exhibits both tautomerase and oxidoreductase activities, although how these are linked to MIF’s physiological and pathophysiological actions is unclear. MIF antagonist, also known as ISO-1, is an inhibitor of the dopachrome tautomerase activity of MIF in vitro (IC50 = 7 μM) and in cells (IC50 = 25 μM). It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis. MIF antagonist also demonstrates protective effects in airway and gastrointestinal inflammation in mice.More related product prices
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Suppliers and manufacturers
Henan Aochuang Chemical Co.,Ltd.
Shanghai UCHEM Inc.
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
HANGZHOU LEAP CHEM CO., LTD.
Hebei Chuanghai Biotechnology Co., Ltd
TargetMol Chemicals Inc.
Zibo Hangyu Biotechnology Development Co., Ltd
Aladdin Scientific
MIF Antagonist, ISO-1
CAS:478336-92-4