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ChemicalBook >> CAS DataBase List >> AST 487

AST 487

$30 - $1950
Product name: AST 487
CAS: 630124-46-8
MF: C26H30F3N7O2
MW: 529.56
EINECS:205-525-8
MDL Number:MFCD11983171
Synonyms:AST 487;NVP-AST 487;1-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-3-(4-{[6-(methylamino)-4-pyrimidinyl]oxy}phenyl)urea;AST487 (NVP- AST487);N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea;Urea,N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-;CS-562;3-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}-1-(4-{[6-(METHYLAMINO)PYRIMIDIN-4-YL]OXY}PHENYL)UREA

Price63 Properties Safety Information Description

63 prices

Selected condition：

Brand

aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Biosynth
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
Sigma-Aldrich
TRC
Usbiological

Package

10mM(in 1mL DMSO)
2.5mg
10mM(in1mLDMSO)
1mg
2mg
5mg
10mg
25mg
50mg
100mg
250mg
1g

Manufactureraablocks
Product numberAA003AG6
Product descriptionN-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea ≥98%
Packaging1mg
Price$37
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA003AG6
Product descriptionN-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea 99%
Packaging5mg
Price$52
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA003AG6
Product descriptionN-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea
Packaging25mg
Price$178
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA003AG6
Product descriptionN-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea
Packaging50mg
Price$318
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA003AG6
Product descriptionN-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea
Packaging100mg
Price$465
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberY228196
Product descriptionAST 487 97.00%
Packaging100MG
Price$665
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberY228196
Product descriptionAST 487 97.00%
Packaging25MG
Price$235
Updated2026-05-27
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1210-M050
Product descriptionAST-487 ≥95%
Packaging50mg
Price$972
Updated2021-12-16
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3745-M025
Product descriptionAST-487 ≥95%
Packaging25mg
Price$250
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3745-M005
Product descriptionAST-487 ≥95%
Packaging5mg
Price$90
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3745-M001
Product descriptionAST-487 ≥95%
Packaging1mg
Price$30
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberSYN-1210-M001
Product descriptionAST-487 ≥95%
Packaging1mg
Price$97
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberSYN1210
Product descriptionAST-48
Packaging50mg
Price$1576.85
Updated2021-12-16
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ManufacturerAmbeed
Product numberA248926
Product description1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea 98+%
Packaging5mg
Price$253
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA248926
Product description1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea 98+%
Packaging10mg
Price$455
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0013792
Product descriptionAST-487 95.00%
Packaging1MG
Price$216.3
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA003AG6	N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea ≥98%	1mg	$37	2026-05-28	Buy
aablocks	AA003AG6	N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea 99%	5mg	$52	2026-05-28	Buy
aablocks	AA003AG6	N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea	25mg	$178	2026-05-28	Buy
aablocks	AA003AG6	N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea	50mg	$318	2026-05-28	Buy
aablocks	AA003AG6	N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea	100mg	$465	2026-05-28	Buy
ACHEMBLOCK	Y228196	AST 487 97.00%	100MG	$665	2026-05-27	Buy
ACHEMBLOCK	Y228196	AST 487 97.00%	25MG	$235	2026-05-27	Buy
Adipogen Life Sciences	SYN-1210-M050	AST-487 ≥95%	50mg	$972	2021-12-16	Buy
Adipogen Life Sciences	AG-CR1-3745-M025	AST-487 ≥95%	25mg	$250	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3745-M005	AST-487 ≥95%	5mg	$90	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3745-M001	AST-487 ≥95%	1mg	$30	2026-05-06	Buy
Adipogen Life Sciences	SYN-1210-M001	AST-487 ≥95%	1mg	$97	2021-12-16	Buy
AK Scientific	SYN1210	AST-48	50mg	$1576.85	2021-12-16	Buy
Ambeed	A248926	1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea 98+%	5mg	$253	2021-12-16	Buy
Ambeed	A248926	1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea 98+%	10mg	$455	2021-12-16	Buy
American Custom Chemicals Corporation	API0013792	AST-487 95.00%	1MG	$216.3	2021-12-16	Buy

Next Last

Properties

Melting point :162-164°C
Boiling point :563.1±50.0 °C(Predicted)
Density :1.341±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.33±0.70(Predicted)
form :Solid
color :White to Light Yellow
InChIKey :ODPGGGTTYSGTGO-UHFFFAOYSA-N
SMILES :CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(NC3=CC=C(OC4=NC=NC(NC)=C4)C=C3)=O)C=C2)CC1

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

AST-487 is an inhibitor of RET (IC50 = 0.88 μM), FLT3 (Ki = 0.52 μM), KDR (IC50 = 0.17 μM), c-Abl (IC50 = 0.02 μM), and c-Kit (IC50 = 0.5 μM). It has been shown to inhibit RET autophosphorylation and activation of downstream effectors and to prevent the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. In xenografts of NIH3T3 cells expressing oncogenic RET and of the MTC cell line TT in nude mice, AST-487 dose dependently inhibited tumor growth. It also demonstrates antiproliferative effects on primary cells from acute myelocytic leukemia patients and on cell lines expressing FLT3-ITD or FLT3 kinase domain point mutants.

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Suppliers and manufacturers

career henan chemical co

$1.00
AST 487 CAS:630124-46-8

TargetMol Chemicals Inc.

$72.00
AST 487 CAS:630124-46-8

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InvivoChem

TargetMol Chemicals Inc.

Zibo Hangyu Biotechnology Development Co., Ltd

Aladdin Scientific

Amadis Chemical Company Limited

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AST 487

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Description

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