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ChemicalBook >> CAS DataBase List >> AZD 1480

AZD 1480

AZD 1480 price.
  • $32 - $2158.7
  • Product name: AZD 1480
  • CAS: 935666-88-9
  • MF: C14H14ClFN8
  • MW: 348.77
  • EINECS:
  • MDL Number:MFCD16038904
  • Synonyms:5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;AZD 1480;(S)-5-chloro-N4-(5-Methyl-1H-pyrazol-3-yl)-N2-(1-(5-MethylpyriMidin-2-yl)ethyl)pyriMidine-2,4-diaMine;(S)-5-chloro-N2-(1-(5-fluoropyriMidin-2-yl)ethyl)-N4-(5-Methyl-1H-pyrazol-3-yl)pyriMidine-2,4-diaMine;5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine AZD 1480;AZD 1480 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;AZD1480, >=98%;AZD1480;AZD1480;AZD 1480
81 prices
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  • aablocks
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • AvaChem
  • Biosynth
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  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • Tocris
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Package
  • 10
  • 5mg
  • 1mg
  • 10mM*1mLinDMSO
  • 10mg
  • 25mg
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  • 250mg
  • 1g
  • 10.00g
  • 50.00g
  • 100.00g
  • Manufactureraablocks
  • Product numberAA00GTYE
  • Product descriptionAZD-1480 98+%
  • Packaging10mg
  • Price$61
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00GTYE
  • Product descriptionAZD-1480 98
  • Packaging25mg
  • Price$135
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00GTYE
  • Product descriptionAZD-1480 98+%
  • Packaging50mg
  • Price$152
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00GTYE
  • Product descriptionAZD-1480 98+%
  • Packaging5mg
  • Price$38
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00GTYE
  • Product descriptionAZD-1480 98+%
  • Packaging1mg
  • Price$32
  • Updated2026-05-28
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  • ManufacturerAK Scientific
  • Product numberSYN5710
  • Product descriptionAZD1480
  • Packaging100mg
  • Price$1174
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000831
  • Product descriptionAZD-1480 95.00%
  • Packaging1MG
  • Price$140.7
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000831
  • Product descriptionAZD-1480 95.00%
  • Packaging50MG
  • Price$2158.7
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA4137
  • Product descriptionAZD1480
  • Packaging5mg
  • Price$80
  • Updated2026-05-06
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  • ManufacturerApexBio Technology
  • Product numberA4137
  • Product descriptionAZD1480
  • Packaging10mg
  • Price$130
  • Updated2026-05-06
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  • ManufacturerApexBio Technology
  • Product numberA4137
  • Product descriptionAZD1480
  • Packaging200mg
  • Price$650
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberBISN0012
  • Product descriptionAZD1480 99%
  • Packaging250mg
  • Price$986
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberBISN0012
  • Product descriptionAZD1480 99%
  • Packaging50mg
  • Price$305
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberBISN0012
  • Product descriptionAZD1480 99%
  • Packaging100mg
  • Price$551
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0012
  • Product descriptionAZD1480 99%
  • Packaging50mg
  • Price$156
  • Updated2026-06-04
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  • ManufacturerAvaChem
  • Product number2598
  • Product descriptionAZD1480
  • Packaging50mg
  • Price$235
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00GTYE AZD-1480 98+% 10mg $61 2026-05-28 Buy
aablocks AA00GTYE AZD-1480 98 25mg $135 2026-05-28 Buy
aablocks AA00GTYE AZD-1480 98+% 50mg $152 2026-05-28 Buy
aablocks AA00GTYE AZD-1480 98+% 5mg $38 2026-05-28 Buy
aablocks AA00GTYE AZD-1480 98+% 1mg $32 2026-05-28 Buy
AK Scientific SYN5710 AZD1480 100mg $1174 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000831 AZD-1480 95.00% 1MG $140.7 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000831 AZD-1480 95.00% 50MG $2158.7 2021-12-16 Buy
ApexBio Technology A4137 AZD1480 5mg $80 2026-05-06 Buy
ApexBio Technology A4137 AZD1480 10mg $130 2026-05-06 Buy
ApexBio Technology A4137 AZD1480 200mg $650 2021-12-16 Buy
Apolloscientific BISN0012 AZD1480 99% 250mg $986 2021-12-16 Buy
Apolloscientific BISN0012 AZD1480 99% 50mg $305 2021-12-16 Buy
Apolloscientific BISN0012 AZD1480 99% 100mg $551 2021-12-16 Buy
Apolloscientific BISN0012 AZD1480 99% 50mg $156 2026-06-04 Buy
AvaChem 2598 AZD1480 50mg $235 2021-12-16 Buy

Properties

Melting point :>205°C (dec.)
Boiling point :575.2±60.0 °C(Predicted)
Density :1.517
storage temp. :-20°C
solubility :Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
form :powder
pka :13.73±0.10(Predicted)
color :white to beige
InChI :InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
InChIKey :PDOQBOJDRPLBQU-QMMMGPOBSA-N
SMILES :C1(N[C@H](C2=NC=C(F)C=N2)C)=NC=C(Cl)C(NC2C=C(C)NN=2)=N1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:

Description

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). AZD1480 is a potent JAK2 inhibitor that blocks signaling (IC50 = 58 nM at 5 mM ATP) and proliferation of JAK2-expressing cell lines (GI50 = 60 nM). It is selective for JAK2 over other JAK family members as well as a panel of related kinases. AZD1480 also inhibits the growth of cells expressing the V617F mutant of JAK2 (GI50 = 60 nM). It reversibly blocks JAK2-mediated phosphorylation of STAT3 and STAT5. AZD1480 displays good pharmacokinetics in vivo, inhibits STAT3 and STAT5 activation in vivo, and suppresses tumorigenesis in mouse xenografts harboring constitutive STAT3 activity. In addition to suppressing myeloma cell growth and survival, AZD1480 reduces angiogenesis and metastasis in vitro and in human xenograft tumor models.

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