Binimetinib
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- $12 - $9990
- Product name: Binimetinib
- CAS: 606143-89-9
- MF: C17H15BrF2N4O3
- MW: 441.23
- EINECS:
- MDL Number:MFCD22124525
- Synonyms:5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;MEK162 (ARRY-438162);MEK162 (ARRY-162, ARRY-438162);BiniMetinib (MEK162, ARRY-162, ARRY-438162);1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-;5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide Binimetinib (MEK162, ARRY-162, ARRY-438162);ARRY-438162 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;Binimetinib
91 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
Package
- 250mg
- 500mg
- 1000mg
- 50.00g
- 10mM*1mLinDMSO
- 20mg
- 5g
- 100.00g
- 250.00g
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mg
- 50mg
- 1G
- 25MG
- 100mg
- 200mg
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA0039B3
- Product description5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 98%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039B3
- Product description5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 98%
- Packaging5mg
- Price$14
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039B3
- Product description5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide ≥98%
- Packaging10mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039B3
- Product description5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 98%
- Packaging50mg
- Price$58
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039B3
- Product description5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 98%
- Packaging100mg
- Price$90
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039B3
- Product description5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
- Packaging200mg
- Price$144
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8887
- Product descriptionMEK162 98%
- Packaging100MG
- Price$85
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8887
- Product descriptionMEK162 98%
- Packaging25MG
- Price$60
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8887
- Product descriptionMEK162 98%
- Packaging1G
- Price$750
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberY1468
- Product descriptionMEK162
- Packaging10mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001469
- Product descriptionMEK-162 95.00%
- Packaging5MG
- Price$168.3
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001469
- Product descriptionMEK-162 95.00%
- Packaging1G
- Price$1659
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1947
- Product descriptionMEK162(ARRY-162,ARRY-438162)
- Packaging50mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1947
- Product descriptionMEK162(ARRY-162,ARRY-438162)
- Packaging100mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1947
- Product descriptionMEK162(ARRY-162,ARRY-438162)
- Packaging10mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1947
- Product descriptionMEK162 (ARRY-162, ARRY-438162)
- Packaging10mg
- Price$77
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0039B3 | 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 98% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA0039B3 | 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 98% | 5mg | $14 | 2026-05-28 | Buy |
| aablocks | AA0039B3 | 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide ≥98% | 10mg | $22 | 2026-05-28 | Buy |
| aablocks | AA0039B3 | 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 98% | 50mg | $58 | 2026-05-28 | Buy |
| aablocks | AA0039B3 | 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 98% | 100mg | $90 | 2026-05-28 | Buy |
| aablocks | AA0039B3 | 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide | 200mg | $144 | 2026-05-28 | Buy |
| ACHEMBLOCK | H-8887 | MEK162 98% | 100MG | $85 | 2026-05-27 | Buy |
| ACHEMBLOCK | H-8887 | MEK162 98% | 25MG | $60 | 2026-05-27 | Buy |
| ACHEMBLOCK | H-8887 | MEK162 98% | 1G | $750 | 2026-05-27 | Buy |
| AK Scientific | Y1468 | MEK162 | 10mg | $138 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001469 | MEK-162 95.00% | 5MG | $168.3 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001469 | MEK-162 95.00% | 1G | $1659 | 2021-12-16 | Buy |
| ApexBio Technology | A1947 | MEK162(ARRY-162,ARRY-438162) | 50mg | $150 | 2021-12-16 | Buy |
| ApexBio Technology | A1947 | MEK162(ARRY-162,ARRY-438162) | 100mg | $240 | 2021-12-16 | Buy |
| ApexBio Technology | A1947 | MEK162(ARRY-162,ARRY-438162) | 10mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | A1947 | MEK162 (ARRY-162, ARRY-438162) | 10mg | $77 | 2026-05-06 | Buy |
Properties
Melting point :>203oC (dec.)
Density :1.67
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :14.20±0.10(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey :ACWZRVQXLIRSDF-UHFFFAOYSA-N
SMILES :C1N(C)C2=CC(C(NOCCO)=O)=C(NC3=CC=C(Br)C=C3F)C(F)=C2N=1
Density :1.67
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :14.20±0.10(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey :ACWZRVQXLIRSDF-UHFFFAOYSA-N
SMILES :C1N(C)C2=CC(C(NOCCO)=O)=C(NC3=CC=C(Br)C=C3F)C(F)=C2N=1
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
Binimetinib is an orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM). It has been found to inhibit ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM). This compound is efficacious in several xenograft tumor models in mice, including those bearing K-Ras or B-Raf mutations, and has been characterized in clinical studies using patients with N-Ras melanoma, non-small cell lung cancer, or biliary tract cancer.Related product price
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Suppliers and manufacturers
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Jinan Carbotang Biotech Co.,Ltd.
BOC Sciences
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
ANHUI WITOP BIOTECH CO., LTD
Binimetinib
CAS:606143-89-9
