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ChemicalBook >> CAS DataBase List >> CO-1686

CO-1686

$9 - $3510
Product name: CO-1686
CAS: 1374640-70-6
MF: C27H28F3N7O3
MW: 555.55
EINECS:-0
MDL Number:MFCD26793864
Synonyms:CO-1686;AVL-301;CNX-419;CO-1686 (AVL-301);CO-1686/CO1686;N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide;Clovis CO-1686;CO-1686(free base)

Price67 Properties Safety Information Description

67 prices

Selected condition：

Brand

A1 Biochem Labs
aablocks
ACHEMBLOCK
AK Scientific
ApexBio Technology
Arctom
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
TRC

Package

20mg
500mg
1000mg
10mM(in1mLDMSO)
250.00mg
1g
10mM*1mLinDMSO
1.00g
10mM(in 1mL DMSO)
1mg
5mg
10mg
50mg
100mg
100.00mg
250mg
5G

ManufacturerA1 Biochem Labs
Product numberA1-04311
Product descriptionRociletinib
Packaging1g
Price$700
Updated2021-12-16
Buy

Manufactureraablocks
Product numberAA0039ID
Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging1mg
Price$9
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0039ID
Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging5mg
Price$12
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0039ID
Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging10mg
Price$14
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0039ID
Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging50mg
Price$36
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0039ID
Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging100mg
Price$47
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0039ID
Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
Packaging250mg
Price$76
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product number10304
Product descriptionCO-1686 98%
Packaging100MG
Price$50
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product number10304
Product descriptionCO-1686 98%
Packaging100MG
Price$50
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product number10304
Product descriptionCO-1686 98%
Packaging1G
Price$200
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10304
Product descriptionCO-1686 98%
Packaging1G
Price$200
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product number10304
Product descriptionCO-1686 98%
Packaging5G
Price$650
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10304
Product descriptionCO-1686 98%
Packaging5G
Price$650
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product number2334AH
Product descriptionCO-1686
Packaging100mg
Price$320
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number2334AH
Product descriptionCO-1686
Packaging10mg
Price$151
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberSYN5708
Product descriptionCO-1686
Packaging10mg
Price$160
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
A1 Biochem Labs	A1-04311	Rociletinib	1g	$700	2021-12-16	Buy
aablocks	AA0039ID	N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	1mg	$9	2026-05-28	Buy
aablocks	AA0039ID	N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	5mg	$12	2026-05-28	Buy
aablocks	AA0039ID	N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	10mg	$14	2026-05-28	Buy
aablocks	AA0039ID	N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	50mg	$36	2026-05-28	Buy
aablocks	AA0039ID	N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	100mg	$47	2026-05-28	Buy
aablocks	AA0039ID	N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%	250mg	$76	2026-05-28	Buy
ACHEMBLOCK	10304	CO-1686 98%	100MG	$50	2026-05-25	Buy
ACHEMBLOCK	10304	CO-1686 98%	100MG	$50	2026-05-27	Buy
ACHEMBLOCK	10304	CO-1686 98%	1G	$200	2026-05-25	Buy
ACHEMBLOCK	10304	CO-1686 98%	1G	$200	2026-05-27	Buy
ACHEMBLOCK	10304	CO-1686 98%	5G	$650	2026-05-25	Buy
ACHEMBLOCK	10304	CO-1686 98%	5G	$650	2026-05-27	Buy
AK Scientific	2334AH	CO-1686	100mg	$320	2021-12-16	Buy
AK Scientific	2334AH	CO-1686	10mg	$151	2021-12-16	Buy
AK Scientific	SYN5708	CO-1686	10mg	$160	2021-12-16	Buy

Next Last

Properties

Melting point :202 - 205°C (dec.)
Density :1.372±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :13.23±0.70(Predicted)
color :Off-White
CAS DataBase Reference :1374640-70-6

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321	Specific treatment (see … on this label).
P330	Rinse mouth.
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

CO-1686 is an irreversible kinase inhibitor that specifically targets mutant forms of the epidermal growth factor receptor (EGFR) including T790M (Ki = 21.5 nM) with significantly reduced activity at the wild-type form of the receptor (Ki = 303.3 nM). CO-1686 has been shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR with GI50 values ranging from 7-32 nM in vitro, inducing apoptosis. It also demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and transgenic models dosed orally at 100 mg/kg/day.

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Suppliers and manufacturers

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$1.00
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CO-1686

Properties

Safety Information

Description

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