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ChemicalBook >> CAS DataBase List >> CYCLOPAMINE

CYCLOPAMINE

CYCLOPAMINE price.
  • $14 - $2189
  • Product name: CYCLOPAMINE
  • CAS: 4449-51-8
  • MF: C27H41NO2
  • MW: 411.62
  • EINECS:
  • MDL Number:MFCD09878269
  • Synonyms:11-DEOXOJERVINE;CyclopaMine, froM VeratruM californiciM;CYCLOPAMINE;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-;Cyclopamine 11-Deoxojervine (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol;Cyclopamine, >=98%;(3S,6AS,6bS,8aR,10S,12aS,13S,13aS,15aS,15bR)-10,13,14,15b-tetramethyl-1,2,3,4,6,6a,6b,7,7a,8a;11-DEOXYJERVINE
131 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Thermo Scientific Chemicals
  • Tocris
  • Usbiological
Package
  • 1unit
  • 10mM(in1mLDMSO)
  • 10mM(in 1mL DMSO)
  • 1
  • 10mM*1mLinDMSO
  • EvaluationSample
  • 1mg
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50MG
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • Manufactureraablocks
  • Product numberAA00D7XW
  • Product descriptionCyclopamine 98%
  • Packaging1mg
  • Price$14
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00D7XW
  • Product descriptionCyclopamine 98%
  • Packaging5mg
  • Price$33
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00D7XW
  • Product descriptionCyclopamine 98%
  • Packaging10mg
  • Price$52
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00D7XW
  • Product descriptionCyclopamine 98%
  • Packaging25mg
  • Price$96
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00D7XW
  • Product descriptionCyclopamine 98
  • Packaging100mg
  • Price$306
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberV155924
  • Product descriptionCyclopamine 98%
  • Packaging100MG
  • Price$395
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberV155924
  • Product descriptionCyclopamine 98%
  • Packaging50MG
  • Price$245
  • Updated2026-05-27
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0028-M005
  • Product descriptionCyclopamine ≥98%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0028-M001
  • Product descriptionCyclopamine ≥98%(HPLC)
  • Packaging1mg
  • Price$25
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0028-M005
  • Product descriptionCyclopamine ≥98%(HPLC)
  • Packaging5mg
  • Price$60
  • Updated2026-05-06
  • Buy
  • ManufacturerAK Scientific
  • Product numberX0052
  • Product descriptionCyclopamine 98%(HPLC),powder
  • Packaging5mg
  • Price$67
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberX0052
  • Product descriptionCyclopamine
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX0052
  • Product descriptionCyclopamine
  • Packaging10mg
  • Price$113
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX0052
  • Product descriptionCyclopamine 98%(HPLC),powder
  • Packaging25mg
  • Price$169
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberX0052
  • Product descriptionCyclopamine
  • Packaging25mg
  • Price$247
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX0052
  • Product descriptionCyclopamine 98%(HPLC),powder
  • Packaging100mg
  • Price$430
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00D7XW Cyclopamine 98% 1mg $14 2026-05-28 Buy
aablocks AA00D7XW Cyclopamine 98% 5mg $33 2026-05-28 Buy
aablocks AA00D7XW Cyclopamine 98% 10mg $52 2026-05-28 Buy
aablocks AA00D7XW Cyclopamine 98% 25mg $96 2026-05-28 Buy
aablocks AA00D7XW Cyclopamine 98 100mg $306 2026-05-28 Buy
ACHEMBLOCK V155924 Cyclopamine 98% 100MG $395 2026-05-27 Buy
ACHEMBLOCK V155924 Cyclopamine 98% 50MG $245 2026-05-27 Buy
Adipogen Life Sciences AG-CN2-0028-M005 Cyclopamine ≥98% 5mg $50 2021-12-16 Buy
Adipogen Life Sciences AG-CN2-0028-M001 Cyclopamine ≥98%(HPLC) 1mg $25 2026-05-06 Buy
Adipogen Life Sciences AG-CN2-0028-M005 Cyclopamine ≥98%(HPLC) 5mg $60 2026-05-06 Buy
AK Scientific X0052 Cyclopamine 98%(HPLC),powder 5mg $67 2026-06-04 Buy
AK Scientific X0052 Cyclopamine 5mg $75 2021-12-16 Buy
AK Scientific X0052 Cyclopamine 10mg $113 2021-12-16 Buy
AK Scientific X0052 Cyclopamine 98%(HPLC),powder 25mg $169 2026-06-04 Buy
AK Scientific X0052 Cyclopamine 25mg $247 2021-12-16 Buy
AK Scientific X0052 Cyclopamine 98%(HPLC),powder 100mg $430 2026-06-04 Buy

Properties

Melting point :236-238°C
Boiling point :531.29°C (rough estimate)
Density :1.0274 (rough estimate)
refractive index :1.6400 (estimate)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :15.05±0.70(Predicted)
color :White
Stability :Store in Freezer at - 20°C
InChIKey :QASFUMOKHFSJGL-LAFRSMQTSA-N
SMILES :C1C2[C@@]([H])(CC[C@@]3([C@H](C)[C@]4([H])NC[C@@H](C)C[C@@]4([H])O3)C=2C)[C@@]2([H])[C@@]1([H])[C@@]1(C)CC[C@H](O)CC1=CC2

Safety Information

Symbol(GHS): Skull and Crossbones (GHS06)Health Hazard (GHS08)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Description

Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of action, cyclopamine inhibits hedgehog-dependent expression of Pax7 with an IC50 value of 24 nM. Although teratogenic during development, cyclopamine has potential applications in the treatment of cancer.

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