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ChemicalBook >> CAS DataBase List >> GDC-0068

GDC-0068

$28 - $2964
Product name: GDC-0068
CAS: 1001264-89-6
MF: C24H32ClN5O2
MW: 458
EINECS:
MDL Number:MFCD22124514
Synonyms:(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone;Ipatasertib (GDC-0068);(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one;(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone Ipatasertib (GDC-0068);GDC-0068 (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone;(2S)-2-(4-Chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-1-piperazinyl}-3-(isopropylamino)-1-propanone;Ipatasertib (GDC-0068,RG 7440);GDC-0068;RG7440; GDC0068; GDC 0068; RG-7440; RG 7440

Price90 Properties Safety Information Description

90 prices

Selected condition：

Brand

aablocks
ACHEMBLOCK
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
AvaChem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Thermo Scientific Chemicals
TRC

Package

2mg
10mM*1mLinDMSO(Solid+Solvent)
5mg
EvaluationSample
10mM*1mLinDMSO
1unit
10mM*1mLinDMSO(Solution)
1mg
10mg
10mM(in1mLDMSO)
25mg
50mg
100mg
200mg
10mM(in 1mL DMSO)
250mg
500mg
1G

Manufactureraablocks
Product numberAA0000XK
Product description(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%
Packaging5mg
Price$37
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA0000XK
Product description(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%
Packaging10mg
Price$53
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA0000XK
Product description(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%
Packaging25mg
Price$130
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA0000XK
Product description(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%
Packaging50mg
Price$156
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA0000XK
Product description(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%
Packaging100mg
Price$238
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10323
Product descriptionGDC-0068 98%
Packaging25MG
Price$340
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10323
Product descriptionGDC-0068 98%
Packaging25MG
Price$340
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product number10323
Product descriptionGDC-0068 98%
Packaging100MG
Price$350
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10323
Product descriptionGDC-0068 98%
Packaging100MG
Price$350
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product number10323
Product descriptionGDC-0068 98%
Packaging5MG
Price$115
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10323
Product descriptionGDC-0068 98%
Packaging5MG
Price$115
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product number10323
Product descriptionGDC-0068 98%
Packaging1G
Price$1550
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10323
Product descriptionGDC-0068 98%
Packaging1G
Price$1550
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product numberSYN5726
Product descriptionGDC-0068
Packaging50mg
Price$757
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0013721
Product descriptionGDC-0068 95.00%
Packaging5MG
Price$459.8
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA3006
Product descriptionGDC-0068 (RG7440)
Packaging100mg
Price$495
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA0000XK	(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%	5mg	$37	2026-05-25	Buy
aablocks	AA0000XK	(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%	10mg	$53	2026-05-25	Buy
aablocks	AA0000XK	(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%	25mg	$130	2026-05-25	Buy
aablocks	AA0000XK	(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%	50mg	$156	2026-05-25	Buy
aablocks	AA0000XK	(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone 98%	100mg	$238	2026-05-25	Buy
ACHEMBLOCK	10323	GDC-0068 98%	25MG	$340	2026-05-25	Buy
ACHEMBLOCK	10323	GDC-0068 98%	25MG	$340	2026-05-27	Buy
ACHEMBLOCK	10323	GDC-0068 98%	100MG	$350	2026-05-25	Buy
ACHEMBLOCK	10323	GDC-0068 98%	100MG	$350	2026-05-27	Buy
ACHEMBLOCK	10323	GDC-0068 98%	5MG	$115	2026-05-25	Buy
ACHEMBLOCK	10323	GDC-0068 98%	5MG	$115	2026-05-27	Buy
ACHEMBLOCK	10323	GDC-0068 98%	1G	$1550	2026-05-25	Buy
ACHEMBLOCK	10323	GDC-0068 98%	1G	$1550	2026-05-27	Buy
AK Scientific	SYN5726	GDC-0068	50mg	$757	2021-12-16	Buy
American Custom Chemicals Corporation	API0013721	GDC-0068 95.00%	5MG	$459.8	2021-12-16	Buy
ApexBio Technology	A3006	GDC-0068 (RG7440)	100mg	$495	2026-05-06	Buy

Next Last

Properties

Melting point :>106°C (dec.)
Boiling point :669.4±55.0 °C(Predicted)
Density :1.254
storage temp. :Hygroscopic, Refrigerator, under inert atmosphere
solubility :Soluble in DMSO.
pka :13.11±0.40(Predicted)
form :Solid
color :peachy

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405	Store locked up.

Description

GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays. It is 620-fold selective for Akt over protein kinase A and has been shown to block Akt signaling selectively in cultured tumor cell lines characterized by activated Akt, halting cell cycle progression and reducing cell viability. In multiple tumor xenograft models, oral administration of GDC-0068 at 100 mg/kg/day can lead to delayed tumor growth and regression.

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Suppliers and manufacturers

career henan chemical co

$2.00
GDC-0068 CAS:1001264-89-6

TargetMol Chemicals Inc.

$39.00
Ipatasertib CAS:1001264-89-6

ATK CHEMICAL COMPANY LIMITED

Biochempartner

BOC Sciences

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Shanghai UCHEM Inc.

Dideu Industries Group Limited

Zhejiang J&C Biological Technology Co.,Limited

InvivoChem

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GDC-0068

Properties

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Description

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