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ChemicalBook >> CAS DataBase List >> GSK461364

GSK461364

$10 - $3990
Product name: GSK461364
CAS: 929095-18-1
MF: C27H28F3N5O2S
MW: 543.6
EINECS:200-258-5
MDL Number:MFCD12755419
Synonyms:(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide;GSK-461364A;GSK461364(GSK-461364);5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl];5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phen;GSK461364;GSK-461364;GSK4613

Price84 Properties Safety Information Description

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Brand

aablocks
ACHEMBLOCK
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Axon Medchem
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Sigma-Aldrich
TRC

Package

2.5mg
10mM(in1mLEthanol)
1mg
5mg
10mg
25MG
2x25mg
50mg
100mg
200mg
250mg
500mg
1G
10.00g
50.00g
100.00g
5 mg
25 mg

Manufactureraablocks
Product numberAA006801
Product descriptionGSK461364 ≥98%
Packaging1mg
Price$10
Updated2026-05-28
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Manufactureraablocks
Product numberAA006801
Product descriptionGSK461364 98+%
Packaging5mg
Price$38
Updated2026-05-28
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Manufactureraablocks
Product numberAA006801
Product descriptionGSK461364 ≥98%
Packaging10mg
Price$45
Updated2026-05-28
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Manufactureraablocks
Product numberAA006801
Product descriptionGSK461364 ≥98%
Packaging50mg
Price$174
Updated2026-05-28
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Manufactureraablocks
Product numberAA006801
Product descriptionGSK461364 95%
Packaging100mg
Price$347
Updated2026-05-28
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Manufactureraablocks
Product numberAA006801
Product descriptionGSK461364 95%
Packaging250mg
Price$558
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberQ65450
Product description(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide 98%
Packaging100MG
Price$305
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberQ65450
Product description(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide 98%
Packaging25MG
Price$115
Updated2026-05-27
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ManufacturerAK Scientific
Product numberX7374
Product description5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide
Packaging250mg
Price$2474
Updated2021-12-16
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ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0000326
Product description5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00%
Packaging5MG
Price$598
Updated2021-12-16
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ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0000326
Product description5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00%
Packaging1G
Price$3240
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberA8441
Product descriptionGSK461364
Packaging50mg
Price$528
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberA8441
Product descriptionGSK461364
Packaging500mg
Price$1980
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberA8441
Product descriptionGSK461364
Packaging10mg
Price$150
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberA8441
Product descriptionGSK461364
Packaging10mg
Price$165
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberA8441
Product descriptionGSK461364
Packaging10mM(in1mLEthanol)
Price$176
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA006801	GSK461364 ≥98%	1mg	$10	2026-05-28	Buy
aablocks	AA006801	GSK461364 98+%	5mg	$38	2026-05-28	Buy
aablocks	AA006801	GSK461364 ≥98%	10mg	$45	2026-05-28	Buy
aablocks	AA006801	GSK461364 ≥98%	50mg	$174	2026-05-28	Buy
aablocks	AA006801	GSK461364 95%	100mg	$347	2026-05-28	Buy
aablocks	AA006801	GSK461364 95%	250mg	$558	2026-05-28	Buy
ACHEMBLOCK	Q65450	(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide 98%	100MG	$305	2026-05-27	Buy
ACHEMBLOCK	Q65450	(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide 98%	25MG	$115	2026-05-27	Buy
AK Scientific	X7374	5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide	250mg	$2474	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0000326	5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00%	5MG	$598	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0000326	5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00%	1G	$3240	2021-12-16	Buy
ApexBio Technology	A8441	GSK461364	50mg	$528	2026-05-06	Buy
ApexBio Technology	A8441	GSK461364	500mg	$1980	2026-05-06	Buy
ApexBio Technology	A8441	GSK461364	10mg	$150	2021-12-16	Buy
ApexBio Technology	A8441	GSK461364	10mg	$165	2026-05-06	Buy
ApexBio Technology	A8441	GSK461364	10mM(in1mLEthanol)	$176	2026-05-06	Buy

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Properties

Melting point :>150°C (dec.)
Boiling point :658.0±65.0 °C(Predicted)
Density :1.39
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :15.16±0.50(Predicted)
form :Solid
color :Off-White to Light Beige
InChIKey :ZHJGWYRLJUCMRT-QGZVFWFLSA-N
SMILES :CN1CCN(CC2=CC3=C(N=CN3C4=CC(O[C@@H](C5=C(C=CC=C5)C(F)(F)F)C)=C(C(N)=O)S4)C=C2)CC1

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. GSK461364 is a potent, reversible inhibitor of Plk1 (Ki = 2.2 nM). It is less effective against Plk2 and Plk3 (Kis = 860 and 1,000 nM, respectively) and at least 1,000-fold selective for Plk1 over a panel of 48 other kinases. GSK461364 dose-dependently halts cell cycling in diverse proliferating cancer cell lines and, at higher doses, triggers apoptosis. It appears to be more effective against p53-deficient tumors and is able to cross the blood-brain barrier. GSK461364 is effective in vivo, inducing tumor growth inhibition or growth delay in xenograft models in mice.

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Suppliers and manufacturers

career henan chemical co

$1.00
GSK-461364 CAS:929095-18-1

TargetMol Chemicals Inc.

$31.00
GSK461364 CAS:929095-18-1

ATK CHEMICAL COMPANY LIMITED

Alchem Pharmtech,Inc.

CONIER CHEM AND PHARMA LIMITED

ANHUI WITOP BIOTECH CO., LTD

Dideu Industries Group Limited

Finetech Industry Limited

BOC Sciences

Hefei Hirisun Pharmatech Co., Ltd

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GSK461364

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Description

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