一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
010-86108875
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook >> CAS DataBase List >> Nutlin 3a

Nutlin 3a

 Nutlin 3a price.
  • $42 - $10302
  • Product name: Nutlin 3a
  • CAS: 675576-98-4
  • MF: C30H30Cl2N4O4
  • MW: 581.49
  • EINECS:
  • MDL Number:MFCD14636430
  • Synonyms:4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone;Nutlin 3a;Nutlin-3a (chiral);2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3a;Nutlin 3a 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one;4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-
76 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Iris Biotech GmbH
  • Sigma-Aldrich
  • Synthonix
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM(in1mLDMSO)
  • 10mM(in 1mL DMSO)
  • 2mg
  • 10mM*1mLinDMSO
  • 1mg
  • 5
  • 25
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100MG
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • Manufactureraablocks
  • Product numberAA003AN7
  • Product description4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone 98%
  • Packaging1mg
  • Price$42
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003AN7
  • Product description4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone ≥97%
  • Packaging5mg
  • Price$70
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003AN7
  • Product description4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone 98%
  • Packaging10mg
  • Price$118
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003AN7
  • Product description4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone 98%
  • Packaging25mg
  • Price$174
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003AN7
  • Product description4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone 98%
  • Packaging50mg
  • Price$301
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10242
  • Product descriptionNutlin-3a 98%
  • Packaging100MG
  • Price$565
  • Updated2026-05-27
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging25mg
  • Price$324
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging50mg
  • Price$606
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging1g
  • Price$10302
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging10mg
  • Price$154
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging5mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA809136
  • Product description4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99%
  • Packaging2mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004735
  • Product description4-[[(4S,5R)-4,5-BIS-(4-CHLOROPHENYL)-4,5-DIHYDRO-2-[4-METHOXY-2-(1-METHYLETHOXY)PHENYL]-1H-IMIDAZOL-1-YL]CARBONYL]-2-PIPERAZINONE 95.00%
  • Packaging5MG
  • Price$503.17
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3671
  • Product descriptionNutlin-3achiral
  • Packaging50mg
  • Price$580
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3671
  • Product descriptionNutlin-3achiral
  • Packaging200mg
  • Price$1980
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3671
  • Product descriptionNutlin-3achiral
  • Packaging10mM(in 1mL DMSO)
  • Price$185
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA003AN7 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone 98% 1mg $42 2026-05-28 Buy
aablocks AA003AN7 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone ≥97% 5mg $70 2026-05-28 Buy
aablocks AA003AN7 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone 98% 10mg $118 2026-05-28 Buy
aablocks AA003AN7 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone 98% 25mg $174 2026-05-28 Buy
aablocks AA003AN7 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone 98% 50mg $301 2026-05-28 Buy
ACHEMBLOCK 10242 Nutlin-3a 98% 100MG $565 2026-05-27 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 25mg $324 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 50mg $606 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 1g $10302 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 10mg $154 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 5mg $108 2021-12-16 Buy
Ambeed A809136 4-((4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one 99% 2mg $60 2021-12-16 Buy
American Custom Chemicals Corporation INB0004735 4-[[(4S,5R)-4,5-BIS-(4-CHLOROPHENYL)-4,5-DIHYDRO-2-[4-METHOXY-2-(1-METHYLETHOXY)PHENYL]-1H-IMIDAZOL-1-YL]CARBONYL]-2-PIPERAZINONE 95.00% 5MG $503.17 2021-12-16 Buy
ApexBio Technology A3671 Nutlin-3achiral 50mg $580 2021-12-16 Buy
ApexBio Technology A3671 Nutlin-3achiral 200mg $1980 2021-12-16 Buy
ApexBio Technology A3671 Nutlin-3achiral 10mM(in 1mL DMSO) $185 2021-12-16 Buy

Properties

Density :1.36
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear
form :White powder
pka :14.35±0.20(Predicted)
color :white to beige
optical activity :[α]/D -140 to -155° (c=0.5, CDCl3)
InChIKey :BDUHCSBCVGXTJM-WUFINQPMSA-N
SMILES :N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@@H](C3=CC=C(Cl)C=C3)[C@H]2C2=CC=C(Cl)C=C2)=O)CC1=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The protein p53, often called the ‘guardian of the genome,’ is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis. Its role as a tumor suppressor is evident by the observation that approximately 50% of human tumors have mutated or non-functional p53. Mdm2, a key negative regulator of p53, which is over-expressed in many human tumors, functions by binding to and targeting p53 for proteasomal degradation. Nutlin-3 is a potent inhibitor of p53-Mdm2 interaction. (?)-Nutlin-3 is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It potently inhibits Mdm2-p53 binding with an IC50 value of 0.09 μM, induces the expression of p53-regulated genes, and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. (?)-Nutlin-3 inhibits the proliferation of exponentially growing human skin and murine fibroblasts with IC50 values of 2.2 and 1.3 μM, respectively, and induces substantial tumor shrinkage in mice expressing LnCaP, 22Rv1 or MHM cancer cell lines when treated orally with a 200 mg/kg dose twice daily for two weeks.

Related product price

奇台县| 丹寨县| 安新县| 兰西县| 宜宾县| 始兴县| 舒兰市| 抚远县| 梅河口市| 汉寿县| 洪湖市| 宿迁市| 鹰潭市| 黎城县| 重庆市| 沐川县| 桂平市| 方正县| 三江| 温泉县| 深圳市| 福鼎市| 玉溪市| 安义县| 北流市| 吉木乃县| 永福县| 肃宁县| 谷城县| 玉门市| 九江县| 济源市| 大姚县| 常州市| 图们市| 陆河县| 贵港市| 孝昌县| 呼和浩特市| 策勒县| 乌恰县|