SB 203580
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- $16 - $2151
- Product name: SB 203580
- CAS: 152121-47-6
- MF: C21H16FN3OS
- MW: 377.43
- EINECS:
- MDL Number:MFCD00922198
- Synonyms:SB 203580 HYDROCHLORIDE;SB 2035850;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL;4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULPHONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE HYDROCHLORIDE; 4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine
147 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Thermo Scientific Chemicals
- Tocris
- TRC
Package
- 10mg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 1unit
- 20mg
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 50
- 1
- 10
- EvaluationSample
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1ml
- 1g
- 50.00g
- 10mM(in1mLDMSO)
- 250.00g
- 100.00g
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA003JYT
- Product description4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98%
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003JYT
- Product description4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine ≥98%(HPLC)
- Packaging5mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003JYT
- Product description4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98%
- Packaging50mg
- Price$56
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003JYT
- Product description4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98%
- Packaging100mg
- Price$83
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003JYT
- Product description4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98%
- Packaging1g
- Price$674
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003JYT
- Product description4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98%
- Packaging250mg
- Price$190
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10377
- Product descriptionSB203580 98%
- Packaging100MG
- Price$120
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10377
- Product descriptionSB203580 98%
- Packaging1G
- Price$720
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0030-M025
- Product descriptionSB 203580 ≥98%
- Packaging25mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0030-M025
- Product descriptionSB203580 ≥99%(HPLC)
- Packaging25mg
- Price$180
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0030-M005
- Product descriptionSB203580 ≥99%(HPLC)
- Packaging5mg
- Price$70
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0030-M001
- Product descriptionSB203580 ≥99%(HPLC)
- Packaging1mg
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberSYN1074
- Product descriptionSB 203580
- Packaging5mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248150
- Product descriptionSB 203580 98+%
- Packaging50mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248150
- Product descriptionSB 203580 98+%
- Packaging5mg
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248150
- Product descriptionSB 203580 98+%
- Packaging10mg
- Price$41
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003JYT | 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98% | 1mg | $16 | 2026-05-28 | Buy |
| aablocks | AA003JYT | 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine ≥98%(HPLC) | 5mg | $19 | 2026-05-28 | Buy |
| aablocks | AA003JYT | 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98% | 50mg | $56 | 2026-05-28 | Buy |
| aablocks | AA003JYT | 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98% | 100mg | $83 | 2026-05-28 | Buy |
| aablocks | AA003JYT | 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98% | 1g | $674 | 2026-05-28 | Buy |
| aablocks | AA003JYT | 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine 98% | 250mg | $190 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10377 | SB203580 98% | 100MG | $120 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10377 | SB203580 98% | 1G | $720 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-0030-M025 | SB 203580 ≥98% | 25mg | $300 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0030-M025 | SB203580 ≥99%(HPLC) | 25mg | $180 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0030-M005 | SB203580 ≥99%(HPLC) | 5mg | $70 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0030-M001 | SB203580 ≥99%(HPLC) | 1mg | $30 | 2026-05-06 | Buy |
| AK Scientific | SYN1074 | SB 203580 | 5mg | $85 | 2021-12-16 | Buy |
| Ambeed | A248150 | SB 203580 98+% | 50mg | $108 | 2021-12-16 | Buy |
| Ambeed | A248150 | SB 203580 98+% | 5mg | $26 | 2021-12-16 | Buy |
| Ambeed | A248150 | SB 203580 98+% | 10mg | $41 | 2021-12-16 | Buy |
Properties
Melting point :144-146
Boiling point :615.6±55.0 °C(Predicted)
Density :1.4
storage temp. :-20°C
solubility :DMSO: 50 mg/mL
form :solid
pka :9.60±0.10(Predicted)
color :white to off-white
Stability :-200C
InChI :InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChIKey :CDMGBJANTYXAIV-UHFFFAOYSA-N
SMILES :C1=NC=CC(C2NC(C3=CC=C(S(C)=O)C=C3)=NC=2C2=CC=C(F)C=C2)=C1
CAS DataBase Reference :152121-47-6(CAS DataBase Reference)
Boiling point :615.6±55.0 °C(Predicted)
Density :1.4
storage temp. :-20°C
solubility :DMSO: 50 mg/mL
form :solid
pka :9.60±0.10(Predicted)
color :white to off-white
Stability :-200C
InChI :InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChIKey :CDMGBJANTYXAIV-UHFFFAOYSA-N
SMILES :C1=NC=CC(C2NC(C3=CC=C(S(C)=O)C=C3)=NC=2C2=CC=C(F)C=C2)=C1
CAS DataBase Reference :152121-47-6(CAS DataBase Reference)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Mitogen-activated protein kinases (MAPK) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. SB 203580 is a pyridinyl imidazole inhibitor of p38 MAPK that specifically blocks its kinase activity. SB 203580 does not however, disrupt JNK activity, which is activated by similar stressors to those which activate p38 MAPK. p38 MAPK activity in heat-shocked HeLa cells and osmotically stressed PC12 cells is inhibited by SB 203580 with an IC50 value of 0.6 μM. SB 203580 also prevents the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1) at IC50 values of 3-5 μM.Related product price
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