去氧腎上腺素堿
| 中文名稱(chēng) | 去氧腎上腺素堿 |
|---|---|
| 中文同義詞 | 3-羥基-alpha-((甲基氨基)甲基)-芐醇;L-苯腎上腺素;L-去氧腎上腺素堿;去羥腎上腺素;去氧腎上腺;新交感酚;新辛內(nèi)井林;L-苯腎上腺素 |
| 英文名稱(chēng) | Phenylephrine |
| 英文同義詞 | component of Dristan cold;component of Dristan nasal mist;component of Entex;component of Histalet forte;component of Hycomine compound;component of Prefrin-a;component of Pv tussin syrup;component of Relief |
| CAS號(hào) | 59-42-7 |
| 分子式 | C9H13NO2 |
| 分子量 | 167.21 |
| EINECS號(hào) | 200-424-8 |
| 相關(guān)類(lèi)別 | 有機(jī)堿;原料;醫(yī)藥原料;日用化學(xué)品;原料藥;化學(xué)試劑 |
| Mol文件 | 59-42-7.mol |
| 結(jié)構(gòu)式 |  |
去氧腎上腺素堿 性質(zhì)
| 熔點(diǎn) | 171°C |
|---|---|
| 沸點(diǎn) | 295.79°C (rough estimate) |
| 密度 | 1.1222 (rough estimate) |
| 折射率 | -55.5 ° (C=5, 1mol/L HCl) |
| 儲(chǔ)存條件 | -20°C Freezer, Under inert atmosphere |
| 溶解度 | 微溶于水，微溶于甲醇，微溶于乙醇（96%）。它溶于稀無(wú)機(jī)酸和堿金屬氫氧化物的稀溶液。 |
| 酸度系數(shù)(pKa) | pKa 8.9 (Uncertain) |
| 形態(tài) | 固體 |
| 顏色 | 白色至類(lèi)白色 |
| 主要應(yīng)用 | 藥物（小分子） |
| InChI | InChI=1/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/s3 |
| InChIKey | SONNWYBIRXJNDC-DJEYLCQNNA-N |
| SMILES | [C@H](C1C=CC=C(O)C=1)(O)CNC |&1:0,r| |
| CAS 數(shù)據(jù)庫(kù) | 59-42-7(CAS DataBase Reference) |
| NIST化學(xué)物質(zhì)信息 | Benzenemethanol, 3-hydroxy-«alpha»-[(methylamino)methyl]-, (r)-(59-42-7) |
(R)-(-)-Phenylephrine is a selective α 1 -adrenoceptor agonist with pK i values of 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca( 2+ )/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis.
Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α 1 -adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema.
安全信息
| 危險(xiǎn)品標(biāo)志 | Xn |
|---|---|
| 危險(xiǎn)類(lèi)別碼 | 22-36/37/38-41-37/38 |
| 安全說(shuō)明 | 26-36-45-39 |
| WGK Germany | WGK 3 |
| RTECS號(hào) | DO7175000 |
| 海關(guān)編碼 | 2922.19.7000 |
| 存儲(chǔ)類(lèi)別 | 11 - 可燃固體 |
| 危險(xiǎn)性類(lèi)別 | 急性毒性 類(lèi)別4 經(jīng)口 嚴(yán)重眼損傷 類(lèi)別1 經(jīng)皮刺激 類(lèi)別2 特異性靶器官毒性-一次接觸，類(lèi)別3 |
| 毒害物質(zhì)數(shù)據(jù) | 59-42-7(Hazardous Substances Data) |
| 毒性 | LD50 oral in rat: 350mg/kg |