S-布洛芬
| 中文名稱 | S-布洛芬 |
|---|---|
| 中文同義詞 | S-布洛芬;S-布洛芬 5G;雷美替胺雜質(zhì)G;(S)-(+)-布洛芬, 95+%;(S)-(+)-布洛芬 [(S)-(+)-2-(4-異丁基苯)丙酸];(2S)-2-(4-異丁基苯)丙酸;(S)-(+)-布洛芬/2-(4-異丁基苯基)丙酸;(S)-2-(4-異丁基苯基)丙酸 |
| 英文名稱 | (S)-(+)-Ibuprofen |
| 英文同義詞 | (S)-(+)-2-(4-ISOBUTYLPHENYL)PROPIONIC ACID;(S)-(+)-4-ISOBUTYL-ALPHA-METHYLPHENYLACETIC ACID;(S)-(+)-IBUPROFEN;(2s)-2-[4-(2-methylpropyl)phenyl]propionic acid;(S)-(+)-Ibuprofen ReagentPlus(R), 99%;(S)-2-(4-Isobutylphenyl)propanoic acid, 95+%;(S)-((addition))-Ibuprofen;(S)-(+)-4-Isobutyl-a-methylphenylacetic acid |
| CAS號(hào) | 51146-56-6 |
| 分子式 | C13H18O2 |
| 分子量 | 206.28 |
| EINECS號(hào) | 610-620-9 |
| 相關(guān)類別 | 醫(yī)藥中間體;羧酸;小分子抑制劑;醫(yī)藥原料;神經(jīng)系統(tǒng)用藥;解熱鎮(zhèn)痛藥;醫(yī)藥與生物化工;有機(jī)砌塊;化合物：原料藥;原料藥;Chiral Reagents;Chiral Compound;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;AMIDATE;醫(yī)藥 解熱鎮(zhèn)痛;對(duì)照品-雜質(zhì)對(duì)照品;醫(yī)藥原料藥-科研原料;醫(yī)用原料;醫(yī)用原料;原料;雜質(zhì)對(duì)照品;日用化學(xué)品;醫(yī)藥原料藥;化學(xué)試劑;常規(guī)產(chǎn)品 |
| Mol文件 | 51146-56-6.mol |
| 結(jié)構(gòu)式 |  |
S-布洛芬 性質(zhì)
| 熔點(diǎn) | 49-53 °C(lit.) |
|---|---|
| 比旋光度 | 57 º (c=2, EtOH) |
| 沸點(diǎn) | 285.14°C (rough estimate) |
| 密度 | 1.0364 (rough estimate) |
| 折射率 | 59 ° (C=2, EtOH) |
| 閃點(diǎn) | >230 °F |
| 儲(chǔ)存條件 | Sealed in dry,Room Temperature |
| 溶解度 | 在45%(w/v)aq2-羥丙基-β-環(huán)糊精溶解度為：1.5 mg/mL |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 4.41±0.10(Predicted) |
| 顏色 | 白色 |
| 旋光度 (Optical Rotation) | [α]20/D +59°, c = 2 in ethanol |
| 水溶解性 | insoluble |
| BRN | 3590022 |
| 穩(wěn)定性 | 穩(wěn)定的。與強(qiáng)氧化劑不相容。 |
| InChI | 1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1 |
| InChIKey | HEFNNWSXXWATRW-JTQLQIEISA-N |
| SMILES | CC(C)Cc1ccc(cc1)[C@H](C)C(O)=O |
| CAS 數(shù)據(jù)庫(kù) | 51146-56-6(CAS DataBase Reference) |
|
COX-1 2.1 μM (IC 50 ) |
COX-2 1.6 μM (IC 50 ) |
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 0-1000 μM; 8 days) treatment reduces concentration dependently cell survival in both cell lines to a similar extent.
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 0-1000 μM; 20-72 hours) treatment causes a G0/G1 phase block as well as apoptosis.
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 900 μM; 4-72 hours) treatment shows a down regulation of cyclin A and B and an increase of the cell cycle inhibitory protein p27Kip-1.
(S)-(+)-Ibuprofen inhibits COX activity, thromboxane formation, and platelet aggregation.
(S)-(+)-Ibuprofen inhibits the activation of NF-κB in response to T-cell stimulation with an IC
50
of 61.7 μM.
Cell Proliferation Assay
| Cell Line: | HCT-15 and HCA-7 cells |
| Concentration: | 0 μM, 200 μM, 400 μM, 600 μM, 700 μM, 800 μM, 900 μM, and 1000 μM |
| Incubation Time: | 8 days |
| Result: | Reduced concentration dependently cell survival in both cell lines to a similar extent. |
Cell Cycle Analysis
| Cell Line: | HCT-15 and HCA-7 cells |
| Concentration: | 0 μM, 200 μM, 400 μM, 600 μM, 800 μM, 900 μM, and 1000 μM |
| Incubation Time: | 24 hours (HCT-15) or 20 hours (HCA-7) |
| Result: | Caused a G0/G1 phase block. |
Apoptosis Analysis
| Cell Line: | HCT-15 and HCA-7 cells |
| Concentration: | 0 μM, 200 μM, 400 μM, 600 μM, 800 μM, 900 μM, and 1000 μM |
| Incubation Time: | 72 hours |
| Result: | Induced cell apoptosis. |
Western Blot Analysis
| Cell Line: | HCT-15 and HCA-7 cells |
| Concentration: | 900 μM |
| Incubation Time: | 4 hours, 8 hours, 16 hours, 24 hours, 32 hours, 48 hours and 72 hours |
| Result: | Decreased levels of Cyclin D1 protein. |
(S)-(+)-Ibuprofen (15 mg/kg/day; intraperitoneal injection; five days a week; for 4 weeks) treatment inhibits tumor growth of HCA-7 and HCT-15 xenografts in the nude mice model.
| Animal Model: | NMRI (nu/nu) male mice (6-8 week old ) injected with HCA-7 and HCT-15 cells |
| Dosage: | 15 mg/kg/day |
| Administration: | Intraperitoneal injection; five days a week; for 4 weeks |
| Result: | Inhibited tumor growth of HCA-7 and HCT-15 xenografts in mice. |
安全信息
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| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | 33320 | (S)-(+)-布洛芬 (S)-(+)-Ibuprofen, 99%, Thermo Scientific Chemicals | 51146-56-6 | 1g | 370元 |
| 2026/06/06 | I0549 | (S)-(+)-2-(4-異丁苯基)丙酸 (S)-(+)-2-(4-Isobutylphenyl)propionic Acid | 51146-56-6 | 1G | 110元 |