N-乙酰-5-羥色胺
| 中文名稱 | N-乙酰-5-羥色胺 |
|---|---|
| 中文同義詞 | N-乙酰-5-羥色胺;N-乙?；逅?N-乙酰-5-羥基色胺;N-乙酰-5-羥基色胺;N-乙酰羥色胺;N-乙酰基-5-羥基色胺;羥色胺雜質(zhì)5;N-(2-(5-羥基-1H-吲哚-3-基)乙基)乙酰胺 |
| 英文名稱 | N-ACETYL-5-HYDROXYTRYPTAMINE |
| 英文同義詞 | N-Acetyl-5-hydroxytryptamine, 3-(N-Acetyl-2-aminoethyl)-5-hydroxyindole, 98%;N-Acetyl-5-hydroxytryptamine,N-Acetylserotonin, Normelatonin;3-(2-Acetamidoethyl)-5-hydroxyindole N-Acetylserotonin;N-Acetylserotonin, Normelatonin;Acetylserotonin;N-Acetyl-5-HT;N-Acetyl-5-hydroxy-1H-indole-3-ethaneamine;N-Acetyl-5-hydroxytryptamine,99% |
| CAS號 | 1210-83-9 |
| 分子式 | C12H14N2O2 |
| 分子量 | 218.25 |
| EINECS號 | 214-916-5 |
| 相關(guān)類別 | 化學試劑;試劑和補充物;小分子抑制劑;雜環(huán)化合物;對照品;其他生化試劑;Tryptamines;Amino Acids;Heterocyclic Compounds;Various Metabolites and Impurities;Indoles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;藥物雜質(zhì)及中間體 |
| Mol文件 | 1210-83-9.mol |
| 結(jié)構(gòu)式 |  |
N-乙酰-5-羥色胺 性質(zhì)
| 熔點 | 120-122 °C (lit.) |
|---|---|
| 沸點 | 556.8±40.0 °C(Predicted) |
| 密度 | 1.268±0.06 g/cm3(Predicted) |
| 儲存條件 | 2-8°C |
| 溶解度 | 乙醇：50 mg/mL |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 10.09±0.40(Predicted) |
| 顏色 | 白色 |
| 穩(wěn)定性 | 吸濕性 |
| InChI | 1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15) |
| InChIKey | MVAWJSIDNICKHF-UHFFFAOYSA-N |
| SMILES | CC(=O)NCCc1c[nH]c2ccc(O)cc12 |
| CAS 數(shù)據(jù)庫 | 1210-83-9(CAS DataBase Reference) |
N-乙酰-5-羥色胺是一種內(nèi)源性生物活性胺，是褪黑素生物合成的直接前體，在生理上具有調(diào)節(jié)睡眠、情緒和食欲的作用。
N-Acetyl-5-hydroxytryptamine (NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin) 是褪黑激素的前體，也是一種有效的 TrkB receptor 的選擇性激動劑。| Target | Value |
|
TrkB receptor
() |
N-Acetyl-5-hydroxytryptamine (NAS), a precursor of Melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner.
To explore whether N-Acetyl-5-hydroxytryptamine, can trigger TrkB activation in vivo, TrkB F616A knockin mice are employed, where it has been shown that TrkB F616A activation can be selectively blocked by 1NMPP1, a derivative of kinase inhibitor PP1, leading to TrkB-null phenotypes. To assess whether N-Acetyl-5-hydroxytryptamine can mimic BDNF, cortical neurons from TrkB F616A knockin mice are prepared. In alignment with a previous report, BDNF- and NAS-mediated TrkB phosphorylation are selectively reduced by 1NMPP1 but not by K252a, whereas serotonin or Melatonin had no effect . These findings suggest that NAS strongly provokes both wild-type TrkB and TrkB F616A tyrosine phosphorylation and activation.
安全信息
| 安全說明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 海關(guān)編碼 | 29339900 |
| 存儲類別 | 11 - 可燃固體 |
| 提供商 | 語言 |
|---|---|
|
英文
|