U-63557A
| 中文名稱 | U-63557A |
|---|---|
| 中文同義詞 | 化合物 T11339;化合物FUREGRELATE SODIUM;化合物FUREGRELATE SODIUM,10 MM DMSO 溶液;5-(吡啶-3-基甲基)苯并呋喃-2-甲酸鈉;呋格雷酸鈉(U-63557A) |
| 英文名稱 | U-63557A |
| 英文同義詞 | SODIUM FUREGRELATE;U-63557A;FUREGRELATE SODIUM;FUREGRELATE SODIUM SALT;5-(3-PYRIDINYLMETHYL)-2-BENZOFURANCARBOXYLIC ACID, SODIUM SALT;5-[3,PYRIDINYLMETHYL]BENZO-FURAN-CARBOXYLIC ACID SODIUM SALT;furegralate sodium;5-(3-Pyridinylmethyl)benzofurancarboxylic acid sodium-potassium salt |
| CAS號 | 85666-17-7 |
| 分子式 | C15H12NNaO3 |
| 分子量 | 277.25 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 85666-17-7.mol |
| 結(jié)構(gòu)式 |  |
U-63557A 性質(zhì)
| 儲存條件 | −20°C |
|---|---|
| 溶解度 | DMF：>25mg/mL； DMSO：>21mg/mL；乙醇：>14.5mg/mL； PBS pH 7.2：>16.5 mg/mL |
| 形態(tài) | 白色至類白色結(jié)晶固體。 |
| 顏色 | 白色至淺黃色 |
| 水溶解性 | Soluble in water at approximately 15mg/ml |
Furegrelate Sodium (U-63557A) 是一種有效的、口服的、選擇性的血栓素合酶 (thromboxane synthase) 抑制劑。Furegrelate Sodium 抑制人血小板微粒體血栓素 A2 (TxA2) 合酶，其 IC50 為 15 nM。Furegrelate Sodium 正在開發(fā)作為抗血小板藥物。
Furegrelate Sodium (U-63557A) (1-5 mg/kg; Oral) prevents blockage of the coronary artery.
Furegrelate Sodium (0.1-5 mg/kg; i.v.) prevents the blockage of stenosed coronary arteries caused platelet aggregation.
Furegrelate Sodium blunts the development of hypoxia-induced pulmonary arterial hypertension (PAH) in an established neonatal piglet model primarily by preserving the structural integrity of the pulmonary vasculature.
Furegrelate also is orally available, has a long half-life of 4.2–5.8 hours in adult humans (compared to several other therapies for PAH including nitric oxide and prostacyclin analogs), and reportedly is highly specific for its target enzyme.
| Animal Model: | Mongrel dogs (19-30 kg) |
| Dosage: | 1-5 mg/kg |
| Administration: | Oral (via a gastric tube) |
| Result: | Prevented blockage of the coronary artery. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-106080A | U-63557A Furegrelate sodium | 85666-17-7 | 5mg | 360元 |
| 2026/06/05 | HY-106080AR | U-63557A Furegrelate sodium (Standard) | 85666-17-7 | 5 mg | 1800元 |