α-雌二醇
| 中文名稱 | α-雌二醇 |
|---|---|
| 中文同義詞 | 雌甾-1,3,5(10)三烯-3,17Α-二醇;Α-雌二醇溶液, 100PPM;雌二醇 1G;3,17Α-二羥基-1,3,5(10)-雌三烯;17Α-雌二醇標(biāo)準(zhǔn)品;14-EPI雌二醇;17a-雌二醇;炔雌醇雜質(zhì)L |
| 英文名稱 | Estradiol |
| 英文同義詞 | 1,3,5-estratriene-3,17-alpha-diol;1,3,5-Estratriene-3,17alpha-diol;17alpha-Oestradiol;3,17alpha-Dihydroxyestra-1,3,5(10)-triene;3,17-alpha-dihydroxyoestra-1,3,5(10)-triene;3,17alpha-Dihydroxyoestra-1,3,5(10)-triene;5(10)-triene-3,17-diol,(17-alpha)-estra-3;epiestradial |
| CAS號 | 57-91-0 |
| 分子式 | C18H24O2 |
| 分子量 | 272.39 |
| EINECS號 | 200-354-8 |
| 相關(guān)類別 | 抗生素、生物堿;甾體激素類;醫(yī)藥原料;醫(yī)藥原料藥-科研原料;其它萜類;醫(yī)藥原材料;試劑盒-Elisa試劑盒;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;醫(yī)用原料;化學(xué)試劑 |
| Mol文件 | 57-91-0.mol |
| 結(jié)構(gòu)式 |  |
α-雌二醇 性質(zhì)
| 熔點(diǎn) | 176-180 °C(lit.) |
|---|---|
| 沸點(diǎn) | 355.44°C (rough estimate) |
| 比旋光度 | D20 +53 to +56° (c = 0.9 in dioxane) |
| 密度 | 1.0708 (rough estimate) |
| 折射率 | 1.4800 (estimate) |
| 儲存條件 | Sealed in dry,Room Temperature |
| 溶解度 | 乙醇：50 mg/mL，澄清，無色 |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 10.27±0.60(Predicted) |
| 顏色 | 白色略帶黃色 |
| 生物來源 | synthetic (organic) |
| 水溶解性 | 3.9mg/L(25 ºC) |
| Merck | 14,3704 |
| InChI | 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1 |
| InChIKey | VOXZDWNPVJITMN-SFFUCWETSA-N |
| SMILES | [H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24 |
| CAS 數(shù)據(jù)庫 | 57-91-0(CAS DataBase Reference) |
| NIST化學(xué)物質(zhì)信息 | Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) |
| EPA化學(xué)物質(zhì)信息 | Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
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Human Endogenous Metabolite
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Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.
Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17α-stradiol and its selective receptor, ER-X, are not part of a cl assical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain.17-Estradiol may have enormous implications for hormone replac ement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer disease and ischemic stroke.
安全信息
| 危險(xiǎn)品標(biāo)志 | T,Xn |
|---|---|
| 危險(xiǎn)類別碼 | 45-48-40 |
| 安全說明 | 53-45-24/25-22 |
| 危險(xiǎn)品運(yùn)輸編號 | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS號 | KG3750000 |
| F | 8-10 |
| 海關(guān)編碼 | 29372390 |
| 存儲類別 | 6.1C - 可燃，急性毒性 類別3 毒性化合物或者引起慢性影響的化合物 |
| 危險(xiǎn)性類別 | 危害水生環(huán)境-長期危害 類別1 致癌性 類別2 影響哺乳 生殖細(xì)胞致突變性 類別2 生殖毒性 類別1A |
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