11-羰基-Β-乙酰乳香酸
| 中文名稱 | 11-羰基-Β-乙酰乳香酸 |
|---|---|
| 中文同義詞 | 11-羰基-Β-乙酰乳香酸;乙?；?11酮-Β-乳香酸;乙酰基-11-酮基-Β-乳香酸;11-羰基-B-乙酰乳香酸;3-乙酰-11酮基乳香酸;11-羰基-Β-乙酰乳香酸AKBA;絞股藍(lán) A;乙?；?11-酮基-BETA-乳香酸 |
| 英文名稱 | 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID |
| 英文同義詞 | BOSWELLIC ACID, ACETYL KETO;3-O-ACETYL-11-KETO-BETA-BOSWELLIC ACID;3-ACETYL-11-KETO-BETA-BOSWELLIC ACID;3-ACETYL-11-KETONE-BETA-ACETYLBOSWELLIC ACID;AK-BETABA;ACETYL-11-KETO-B-BOSWELLIC ACID, 3;3-O-ACETYL-11-KETO-BOSWELLIC ACID, BOSWELLIA SERRATA, >99%;11-keto-β-boswellic acid acetate |
| CAS號(hào) | 67416-61-9 |
| 分子式 | C32H48O5 |
| 分子量 | 512.73 |
| EINECS號(hào) | |
| 植物來(lái)源 | 乳香 |
| 相關(guān)類別 | 中藥對(duì)照品;標(biāo)準(zhǔn)品;植物提取物;對(duì)照品;對(duì)照品-中藥對(duì)照品;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;Miscellaneous Natural Products;Pharmaceuticals;標(biāo)準(zhǔn)品，對(duì)照品;化工原料 |
| Mol文件 | 67416-61-9.mol |
| 結(jié)構(gòu)式 |  |
11-羰基-Β-乙酰乳香酸 性質(zhì)
| 熔點(diǎn) | 271℃ |
|---|---|
| 沸點(diǎn) | 600.3±55.0 °C(Predicted) |
| 密度 | 1.13±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 氯仿（微溶）、甲醇（微溶） |
| 酸度系數(shù)(pKa) | 4.28±0.70(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至類白色 |
| 生物來(lái)源 | Boswellia serrata |
| 主要應(yīng)用 | food and beverages |
| InChIKey | HMMGKOVEOFBCAU-BCDBGHSCSA-N |
| SMILES | C[C@@H]1CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@@H](OC(C)=O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2[C@H]1C |
| LogP | 7.418 (est) |
圖：西黃丸藥制劑方法: 采用薄層色譜法和高效液相色譜法建立西黃丸中乳香類成分 11-羰基-β-乙酰乳香酸的方法。運(yùn)用高效液相色譜法對(duì)其進(jìn)行含量測(cè)定，其中 11-羰基-β-乙酰乳香酸含量最低為
0．27% ，最高為1．05% 。建立薄層色譜法和高效液相色譜法可用于西黃丸中 11-羰基-β-乙酰乳香酸的定性定量檢驗(yàn)，可作為西黃丸現(xiàn)行法定檢驗(yàn)標(biāo)準(zhǔn)中乳香顯微鑒別的有益補(bǔ)充。羰基-β-乙酰乳香酸(Acetyl-11-keto-β-BoswellicAcid,AKBA)作為乳香提取物的主要藥效成分之一。一定質(zhì)量濃度的AKBA用于HL-60細(xì)胞即可觀察到細(xì)胞出現(xiàn)凋亡的形態(tài)學(xué)改變,DNA凝膠電泳出現(xiàn)了凋亡特征性的DNA小分子降解片段帶,流式細(xì)胞儀檢測(cè)早期凋亡率最高可達(dá)39.49%,總凋亡率可達(dá)99.9%,并呈時(shí)間和劑量依賴性。所以，AK-BA能誘導(dǎo)HL-60細(xì)胞凋亡,其作用呈劑量和時(shí)間依賴性。KBA作為乳香的單體成分,誘導(dǎo)白血病細(xì)胞凋亡作用強(qiáng),其作用呈一定的劑量和時(shí)間依賴性,在急性髓系白血病治療領(lǐng)域具有良好的臨床應(yīng)用前景。【1】王醇，夏磊，宋志前，等． 乳香中 5 種乳香酸成分含量分析［J］．中
國(guó)中藥雜志，2011，36( 10)1330-1332
【2】崔銳,周金云. 乳香化學(xué)和藥理的研究進(jìn)展 [J]. 中國(guó)藥學(xué)雜志，2003, 38(6): 407-410AKBA (Acetyl-11-keto-β-boswellic acid) 是一種從乳香中提取出的活性化合物，是新穎的 Nrf2 的活化劑。
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Human Endogenous Metabolite
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AKBA (Acetyl-11-keto-β-boswellic acid) significantly reduced infarct volumes and apoptotic cells, and also increased neurologic scores by elevating the Nrf2 and HO-1 expression in brain tissues in middle cerebral artery occlusion (MCAO) rats at 48 hours post reperfusion. In primary cultured neurons, AKBA increased the Nrf2 and HO-1 expression, which provided protection against OGD-induced oxidative insult. Additionally, AKBA treatment increased Nrf2 binding activity to antioxidant-response elements (ARE).
AKBA (Acetyl-11-keto-β-boswellic acid) significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis.
AKBA (Acetyl-11-keto-β-boswellic acid) triggered significant lipolysis in 3T3-L1 adipocytes as shown by reduced neutral lipids in cytosol and increased free fatty acids in culture medium. Increased lipolysis by AKBA was accompanied by up-regulation of lipolytic enzymes, adipocyte triglyceride lipase (ATGL) and hormone sensitive lipase (HSL), and a decreased expression of lipid droplet stability regulator perilipin. In addition, AKBA (Acetyl-11-keto-β-boswellic acid) treatment reduced phenotypic markers of mature adipocyte aP2, adiponectin and glut-4 in mature adipocytes.
AKBA (Acetyl-11-keto-β-boswellic acid) significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA's activity both in the prevention of small intestinal and colonic polyps was more potently than aspirin. Histopathologic examination revealed that AKBA's effect, that is the reduction of polyp size and degree of dysplasia, was more prominent in larger sized polyps, especially those originating in colon.
AKBA (Acetyl-11-keto-β-boswellic acid) administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity. The activity of AKBA was more potent than that of aspirin.
AKBA (Acetyl-11-keto-β-boswellic acid) exhibited anti-cancer activity in vitro and in vivo. With oral application in mice, AKBA significantly inhibited SGC-7901 and MKN-45 xenografts without toxicity.
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/03/03 | S9024 | 11-羰基-Β-乙酰乳香酸 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) | 67416-61-9 | 1mg | 876.59元 |
| 2026/03/03 | S9024 | 11-羰基-Β-乙酰乳香酸 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) | 67416-61-9 | 5mg | 2596.23元 |