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氟伏沙明

氟伏沙明

中文名稱氟伏沙明
中文同義詞氟提肟氨;(E)-5-甲氧基-4-三氟甲基苯戊酮氧-2-氨乙?;?氟伏沙明;氟伏沙明系列雜質(zhì)標(biāo)準(zhǔn)品、對(duì)照品;氟伏沙明-D3;氟伏沙明F603500;馬來(lái)酸氟伏沙明雜質(zhì)D3;氟伏沙明 54739-18-3
英文名稱Fluvoxamine
英文同義詞(1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentanal O-(2-aminoethyl)oxime;(E)-ω-Methoxy-4'-(trifluoromethyl)valerophenone O-(2-aminoethyl)oxime;δ-Methoxy-4'-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime;Fluvoxamine See: F603500;Fluvoxamine Also See: F603500;FLUVOXAMINE;(E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanoneo-(2-aminoethyl)oxime;1-Pentanone, 5-Methoxy-1-[4-(trifluoroMethyl)phenyl]-, O-(2-aMinoethyl)oxiMe, (1E)-
CAS號(hào)54739-18-3
分子式C15H21F3N2O2
分子量318.33
EINECS號(hào)611-193-1
相關(guān)類別神經(jīng)系統(tǒng)用藥;醫(yī)藥原料;雜質(zhì)對(duì)照品;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件54739-18-3.mol
結(jié)構(gòu)式氟伏沙明 結(jié)構(gòu)式

氟伏沙明 性質(zhì)

熔點(diǎn)120-122.5°C
沸點(diǎn)370.6±52.0 °C(Predicted)
密度1.16±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度可溶于氯仿(少量)、DMSO(少量)、甲醇(少量)
形態(tài)油狀
酸度系數(shù)(pKa)pKa 8.7 (Uncertain)
顏色無(wú)色
InChIInChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+
InChIKeyCJOFXWAVKWHTFT-XSFVSMFZSA-N
SMILESC(=N/OCCN)(\C1=CC=C(C(F)(F)F)C=C1)/CCCCOC
CAS 數(shù)據(jù)庫(kù)54739-18-3(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息Fluvoxamine(54739-18-3)

氟伏沙明 用途與合成方法

Fluvoxamine (DU-23000) 是5-羥色胺再吸收抑制劑,有抗抑郁活性。

SSRIs.

Fluvoxamine (DU-23000) is effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine. Fluvoxamine (DU-23000) appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted. Fluvoxamine (DU-23000) was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under each condition in which food was available. The results demonstrate that the potency of fluvoxamine in reducing ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement.

安全信息

MSDS信息

氟伏沙明 化學(xué)藥品說(shuō)明書

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-B0103R氟伏沙明
Fluvoxamine (Standard)
54739-18-35 mg790元
2026/06/05HY-B0103R氟伏沙明
Fluvoxamine (Standard)
54739-18-310 mg1185元
"氟伏沙明"相關(guān)產(chǎn)品信息
甲基環(huán)戊烯醇酮 三(羥甲基)氨基甲烷 甲基環(huán)戊二烯二聚體 戊酸苯酯 甲乙酮肟 甲基三丁酮肟基硅烷 溴菌腈 6-氨基己酸 三氟甲氧基苯 丙酮肟 甘氨酸 四烯雌酮 苯乙酸 5-甲氧基-1-[4-(三氟甲基)苯基]-1-戊酮 鹽酸氯環(huán)嗪 (S)-縮水甘油乙酸酯 馬來(lái)酸氟伏沙明 苯戊酮
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