Compound T0760(SC) NEW
| Price | $45 |
| Package | 500mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-28 |
Product Details
| Product Name: Compound T0760(SC) | CAS No.: 57-88-5 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2025/07/28 |
Product Introduction
Bioactivity
| Name | Compound T0760(SC) |
| Description | Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids. |
| In vitro | METHODS: CD4+ T lymphocytes were incubated with 7-KC (17.5-70 μM) and Cholesterol-MβCD (17.5-70 μM) for 10 min, and T cell membrane order and disorder were assessed using di-4 ANEPPDHQ fluorescent dye. RESULTS: After exposure to 7-KC, T cell membrane order was altered in a dose-dependent manner, with significant reconstitution of membrane order observed only in cells treated with 35 μM Cholesterol, while reconstitution with l7.5 μM Cholesterol induced minimal effects. [1] METHODS: Human gastric cancer cells SNU601, SNU638 and SNU216 were treated with Cholesterol (25-100 μM) for 48 h and cell viability was measured using MTT Assay. RESULTS: Cholesterol caused a dose-dependent decrease in cell viability in all three cell lines. [2] |
| In vivo | METHODS: To induce hypercholesterolemia, STD:ddY mice were fed a high cholesterol diet (1% cholesterol, 0.5% cholic acid, 0.5% olive oil and 93% standard mouse chow). RESULTS: Cholesterol can be used to construct a mouse model of hypercholesterolemia. [3] METHODS: To induce hyperlipidemia, CD-1 mice were fed a high cholesterol diet (2% cholesterol and 0.6% sodium deoxycholate). RESULTS: Cholesterol can be used to construct a mouse model of hyperlipidemia. [4] |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : Insoluble Ethanol : 11.10 mg/mL (28.71 mM), Sonication is recommended. |
| Keywords | unesterified | transporters | SREBP2 | signaling | RORα | phosphorylation | MRP1 | IRS-1 | insulin | Inhibitor | inhibit | exocytic | EstrogenReceptor | Estrogen Receptor/ERR | Estrogen Receptor | ERRα | ERR | EndogenousMetabolite | Endogenous Metabolite | Diabetes | Cholesterol | AKT |
| Inhibitors Related | Sucrose | Cysteamine hydrochloride | D(+)-Raffinose pentahydrate | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oxalic acid |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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