Product Details
| Product Name:
GNE-131 |
CAS No.:
1629063-81-5 |
| Purity:
99.73% |
Supply Ability:
10g |
| Release date:
2026/04/20 |
Product Introduction
Bioactivity
| Name | GNE-131 |
| Description | GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM). |
| In vitro | GNE-131 shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 (IC50: 0.003 μM). |
| In vivo | GNE-131 demonstrates low in vivo clearance in dogs, rats, and mice, and exhibits excellent efficacy in a transgenic mouse model of induced pain [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 120 mg/mL (271.14 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (9.04 mM), Sonication is recommended.
|
| Keywords | SodiumChannel | Sodium Channel | Nav1.7 channel | NaV1.7 | Na+ channels | Na channels | Inhibitor | inhibit | GNE-131 | GNE131 | GNE 131 |
| Inhibitors Related | Phenytoin sodium | Procaine | Ranolazine dihydrochloride | Tetracaine hydrochloride | Lidocaine | Safinamide | Permethrin | Valproic Acid | L-Aspartic aicd sodium | Lidocaine hydrochloride | Mebeverine hydrochloride | Dibucaine |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Sodium Channel Targeted Library | Inhibitor Library | Neuroprotective Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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