Product Details
| Product Name:
GNE-1858 |
CAS No.:
2680616-96-8 |
| Purity:
99.36% |
Supply Ability:
10g |
| Release date:
2026/04/27 |
Product Introduction
Bioactivity
| Name | GNE-1858 |
| Description | GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA). |
| In vitro | HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function.Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4.29 mg/mL (10.01 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.33 mM), Sonication is recommended.
|
| Keywords | T-cell | signaling | regulator | receptor | proliferation | progenitor | negative-feedback | MAPK Kinase Kinase Kinase | MAP4K | Inhibitor | inhibit | HPK1 | hematopoietic | GNE-1858 | GNE1858 | GNE 1858 |
| Inhibitors Related | Sodium lauryl sulfoacetate | Phosphocreatine disodium hydrate | Vemurafenib | SKLB-163 | RV01 | Takinib | NG25 | Phosphocreatine disodium | RMM-46 | Oleanolic Acid | Dehydrocostus Lactone | Sodium new houttuyfonate |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | HIF-1 Signaling Pathway Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Inhibitor Library | Anti-Fibrosis Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library | MAPK Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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